Adding Rhesus Macaque to the Alliance

将恒河猴加入联盟

基本信息

批准号：
10831681
负责人：
CAROL J BULT
金额：
$ 81.08万
依托单位：
CALIFORNIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-18 至 2024-07-31
项目状态：
已结题

项目摘要

Summary We propose to incorporate the rhesus macaque (Macaca mulatta) genome into the Alliance of Genome Resources (Alliance). This one-year project would serve two main purposes. First, it will bring a non-human primate into the Alliance, which will deeply connect knowledge about this important research organism to other research organisms and provide useful features for the macaque research community. Second, it will provide preliminary results and a path forward for a robust knowledgebase project for other non-human primates to be associated with the Alliance. It will also serve as a proof of principle for the Alliance’s agility and scalability. In collaboration with an existing and already interested resource, mGAP (the Macaque Genotype and Phenotype Resource), we will systematically bring information about this macaque genome and genetics into the Alliance. Starting with existing macaque resources (e.g., mGAP for variants, phenotypes, and disease connections) as well as generic resources (NCBI for genome; GOC for Gene annotations; BioGrid/IMEX for molecular interactions; Reactome; OMIM). The Oregon National Primate Research Center (ONPRC) has been interested in joining the Alliance for five years, and we are now ready to engage fully. In particular, the Alliance is well on its way to having an extensible persistent store with a rich-data model handling variants, disease annotations; gene expression; GO annotations; interactions and so forth. We will populate these with macaque data over the year. As the macaque data are incorporated, we will provide for macaque the full suite of features available on the current Alliance site, and others as they become available. Specifically, we will provide a macaque landing page with community-specific content; a community forum; gene pages for all macaque genes; orthology calls for protein-coding genes; an interactive table of variants; disease annotations; a JBrowse2 instance that will visualize variants as well as gene structure models; automated descriptions of gene function that will head each gene page; table of Gene Ontology (GO) annotations; pathways from Reactome and GO-CAM; gene expression; and molecular interactions. Together this will provide a useful resource to the growing non-human primate genome biology community and its connection with a broader set of biomedical researchers.

概括我们建议将鼠泳猕猴（Macaca Mulatta）基因组纳入基因组资源（联盟）。这个为期一年的项目将有两个主要目的。首先，它将将非人类的灵长类动物带入联盟，这将深入联系对其他研究生物的重要研究生物，并为猕猴研究社区。其次，它将提供初步结果和前进的途径一个与联盟相关联的其他非人类隐私的强大知识库项目。它还将作为联盟敏捷性和可扩展性的原理证明。合作 MGAP（猕猴的基因型和表型）有了现有且已经有趣的资源资源），我们将系统地将有关此猕猴基因组和遗传学的信息带入联盟。从现有的猕猴资源开始（例如，用于变体，表型和疾病联系）以及通用资源（基因组的NCBI； GOC用于基因注释；用于分子相互作用的biogrid/imex；反应组； OMIM）。俄勒冈国家灵长类动物研究中心（ONPRC）有兴趣加入联盟已有五年了，我们是现在准备充分参与。特别是，联盟在拥有可扩展的方式方面很好持续的商店，具有丰富的DATA模型处理变体，疾病注释；基因表达；进行注释；互动等。我们将用猕猴数据填充这些年。随着猕猴的数据合并，我们将提供猕猴的完整功能套件在当前联盟网站上可用，而其他联盟网站可用。具体来说，我们会的提供带有社区特定内容的猕猴着陆页；社区论坛；基因所有猕猴基因的页面；矫正要求蛋白质编码基因；互动表变体；疾病注释；一个将可视化变体和基因的JBROWSE2实例结构模型；基因函数的自动描述将负责每个基因页面；桌子基因本体论（GO）注释； Reactome和Go-Cam的途径；基因表达；和分子相互作用。这将为成长的非人类提供有用的资源灵长类动物基因组生物学社区及其与更广泛的生物医学的联系研究人员。