Predoctoral Training Program in Molecular and Cellular Biology (INCLUDE Down Syndrome Supplement)

分子和细胞生物学博士前培训计划（包括唐氏综合症补充剂）

• 批准号: 10828277
• 负责人: Jay R Hesselberth
• 金额: $ 16.73万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10828277
• 关键词: Down Syndrome; Molecular and Cellular Biology; Training Programs; pre-doctoral

ABSTRACT. The goal of the T32-Funded Molecular Biology (MOLB) Program at the University of Colorado Anschutz Medical Campus is to train outstanding research scientists and academicians who will become future leaders in their chosen fields and disciplines. As part of this this goal, we teamed up with Linda Crnic Institute for Down Syndrome to train new high-quality scientist dedicated in pursuing biomedical research to enhance our understanding about the causes and potential treatments of Down Syndrome. Our training program is flexible and student-oriented to meet individual needs, with a rigorous curriculum and high standards. Ph.D. in Molecular Biology is designed as a 5-6 year program with rigorous and challenging course work and research thesis. To further develop their skills, all trainees supported by INCLUDE Supplement will attend monthly Crnic Supergroup research meetings, will present and discuss results of their own project at one such meeting, and will attend the annual Crnic Symposium. As the result, trainees will be exposed to multi-disciplinary approaches to studying DS which will complement their training by their thesis Mentors. Trainees supported by this supplement will also participate in all the activities that are designed for other MOLB T32 awardees, namely organizing annual MOLB Symposium and Retreat as well as running monthly “Roundtables” discussion forum. Finally, all three trainees supported by this supplement will present their work during MOLB Annual Retreat during special “Down Syndrome” session. Given the depth, quality, and diversity of our student pool and our demonstrated ability to train high quality students, we request 4 students be supported for one year as part of INCLUDE Supplement.

摘要。 Anschutz医疗校园将培训固定研究科学家和学士学家，他们将验证未来 我们选择的领域和言语是我们的目标。 让唐氏综合症培训新的高质量科学家致力于追求生物医学研究以增强 我们对综合征的原因和潜在治疗方法的理解。 具有严格的咖啡馆高度的灵活性和面向学生的需求 分子生物学被设计为5 - 6年的计划，具有严格且具有挑战性的课程工作和研究 论文。 超组研究会议，将在一次这样的会议上介绍和讨论自己的项目 将参加年度CRNIC研讨会。 研究DS的方法将与他们的论文导师相称。 该补充剂还将参与为其他Molb T32获奖者设计的所有活动， 即组织年度MOLB研讨会和务虚会以及每月进行每月“圆桌会议”讨论 论坛。 在特殊的“唐氏综合症”期间撤退。 游泳池和我们所展示的能力培训高质量的学生，我们要求4名学生得到一个。 年份作为支持的一部分。

项目成果

The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization.

• DOI: 10.3389/fgene.2021.818668
• 发表时间: 2021
• 期刊: Frontiers in genetics
• 影响因子: 3.7
• 作者: Arora A;Goering R;Lo HYG;Lo J;Moffatt C;Taliaferro JM
• 通讯作者: Taliaferro JM

Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay.

肽基-tRNA 水解速率影响无义介导的 mRNA 降解的效率。

• DOI: 10.1101/2024.01.10.575080
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Kolakada,Divya;Fu,Rui;Biziaev,Nikita;Shuvalov,Alexey;Lore,Mlana;Campbell,AmyE;Cortázar,MichaelA;Sajek,MarcinP;Hesselberth,JayR;Mukherjee,Neelanjan;Alkalaeva,Elena;Jagannathan,Sujatha
• 通讯作者: Jagannathan,Sujatha

Tubulin isotype regulation maintains asymmetric requirement for α-tubulin over β-tubulin.

• DOI: 10.1083/jcb.202202102
• 发表时间: 2023-03-06
• 期刊: The Journal of cell biology

Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress.

精氨酸代谢增强沙门氏菌对氧化应激的抵抗力。

• DOI: 10.1128/iai.00120-23
• 发表时间: 2023
• 期刊: Infection and immunity
• 影响因子: 3.1
• 作者: Margolis,Alyssa;Liu,Lin;Porwollik,Steffen;Till,JamesKarlA;Chu,Weiping;McClelland,Michael;Vázquez-Torres,Andrés
• 通讯作者: Vázquez-Torres,Andrés

Simultaneous measurement of biochemical phenotypes and gene expression in single cells.

同时测量单细胞中的生化表型和基因表达。

• DOI: 10.1093/nar/gkaa240
• 发表时间: 2020
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Richer,AmandaL;Riemondy,KentA;Hardie,Lakotah;Hesselberth,JayR
• 通讯作者: Hesselberth,JayR