FY14. BASE AWARD; ASSESSMENT OF POTENTIAL COCAINE TREATMENT MEDICATIONS IN NON-HUMAN PRIMATES; POP 12/16/2013-12/15/2014; N01DA-14-8913

2014 财年。

基本信息

批准号：
8948501
负责人：
JACK BERGMAN
金额：
$ 84.39万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-12-16 至 2014-12-15
项目状态：
已结题

项目摘要

The main objectives of this project are to determine the effects of compounds using two well-established paradigms: (1) drug discrimination and (2) self-administration. Two distinct experimental protocols, pretreatment and substitution, may be conducted within each paradigm. In the drug discrimination paradigm, male rhesus monkeys will be trained to discriminate an intramuscular injection of cocaine from saline. Subsequently, coded compounds will be studied by determining whether selected doses, administered pre-session, reduce the discriminative-stimulus effects of cocaine (pretreatment) and/or whether selective doses of the compound itself can produce cocaine-like effects (substitution). In the drug self-administration paradigm, Mm will be prepared with indwelling IV catheters, and trained to self-administer IV cocain in daily sessions that also include food self-administration components. Each coded compound will be tested in Mm in which the dose-response function for IV cocaine self-administration has been determined. In the pretreatment protocol, tests will be conducted, first, to identify a pretreatment dose that reduces self-administration of the peak reinforcing unit dose of IV cocaine without greatly altering food self-administration, and second, to determine how that dose alters the cocaine dose response function for IV self-administration. In the substitution protocol, selected unit doses of the coded compound will be made available of IV self-administration to evaluate their reinforcing effects. Follow-up studies may be conducted with promising compounds.

该项目的主要目标是使用两个完善的范例来确定化合物的效果：（1）药物歧视和（2）自我给药。每个范例中可以进行两种不同的实验方案：预处理和替代。在药物辨别范式中，雄性恒河猴将接受训练以区分肌肉注射的可卡因和盐水。随后，将通过确定在会话前施用的选定剂量是否减少可卡因的辨别刺激作用（预处理）和/或化合物本身的选择性剂量是否可以产生可卡因样作用（替代）来研究编码化合物。在药物自我给药范例中，Mm 将准备好留置静脉导管，并接受训练以在日常课程中自行静脉注射可卡因，其中还包括食物自我给药成分。每种编码化合物将在 Mm 中进行测试，其中已确定 IV 可卡因自我给药的剂量反应函数。在预处理方案中，首先将进行测试，以确定预处理剂量，该剂量可减少静脉注射可卡因峰值强化单位剂量的自我给药，而不会极大地改变食物的自我给药，其次，确定该剂量如何改变可卡因IV 自我给药的剂量反应函数。在替代方案中，选定的单位剂量的编码化合物将通过静脉自我给药来评估其增强效果。后续研究可能会针对有前景的化合物进行。