Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents

成人和青少年社会不确定性的神经和行为表征的主体间同步性

基本信息

批准号：
10828675
负责人：
William John Mitchell
金额：
$ 3.44万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-20 至 2025-09-19
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10828675
关键词：
Adolescence Adolescent Adolescent Development Adult Affective Anxiety Anxiety Disorders Applications Grants Attention Automobile Driving Behavioral Belief Characteristics Cognition Cognitive Complex Computing Methodologies Crime Data Decision Making Dedications Development Drama Emotional Emotions Evaluation Exhibits Experimental Designs Familiarity Fellowship Functional Magnetic Resonance Imaging Future Goals Guilt Human Individual Instruction Judgment Knowledge Life Cycle Stages Literature Measurement Measures Memory Mental Depression Mentorship Methods Mood Disorders Moods Neurosciences Research Outcome Participant Pattern Peer Pressure Perception Phase Population Post-Traumatic Stress Disorders Postdoctoral Fellow Predisposition Process Psyche structure Research Research Design Research Personnel Research Project Grants Risk Taking Sampling Severities Social Development Source Stimulus Stressful Event Techniques Time Training Trust Uncertainty Vulnerable Populations Work age related autism spectrum disorder clinically relevant clinically significant computational neuroscience cost emotion dysregulation expectation experience luminance multimodality neural neural circuit neural model neural recruitment neuroimaging neuromechanism novel pre-doctoral response skills social social cognition social neuroscience social situation social stressor theories

项目摘要

Project Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others' beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes. Yet, we understand little of how judgments of social certainty form over time, the neural circuitry underlying these judgments, and how these judgments meaningfully differ from non-social uncertainty sources (e.g., calculations, perceptions). Uncertainty is featured in every developmental stage but adolescents and adults differ in their appraisals of and responses to ambiguity; both social and non-social. Traditional univariate neuroimaging analyses, which compare average magnitudes of activation across broad neural regions, are unresponsive to the subtle pattern differences that characterize complex social cognition. Novel multivariate techniques, such as intersubject correlations (ISC), applied to dynamic, feature-rich, and ecologically-valid sources of social ambiguity are crucial for understanding fundamental aspects of social cognition but have not yet been applied to answer these important questions. F99 Phase: My proposed pre-doctoral project uses a novel study design in which adult participants continuously rate their certainty of a given social (e.g., a character's innocence or guilt) and non-social (e.g., frame luminance) outcome while observing long-form narrative video stimuli (i.e., 45 min crime drama) during fMRI. This yields a continuous time course of concurrently-recorded neural and behavioral data which can be analyzed via ISC to determine the neural circuitry commonly implicated in uncertainty judgment formation among normative adult populations. Interdomain neural-behavioral synchrony can underscore how social and non-social certainty judgment formation mechanisms differ. Defining normative adult neural uncertainty responses provides a crucial comparison to vulnerable populations with pronounced uncertainty responses, including autism spectrum, anxiety, and mood disorders. Training during this phase includes instruction in computational methods relevant to the neuroscience of social decision-making and neurodevelopmental theory to prepare for the K00 Phase. K00 Phase: This phase extends my pre-doctoral research by applying the F99 Phase study design to adolescent populations. This approach could identify whether adults and adolescents are generally relying on distinct or similar neural circuitry to assess the same stimuli and inform subjective indicators of uncertainty (i.e., behavioral ratings). Adolescence is a period marked by intense attention towards social others. The presence of ambiguous social stressors during this period predicts susceptibility to and severity of anxiety and depression into adulthood. Thus, how social uncertainty is processed has notable implications for researchers working at any later developmental stage. The training plan in this phase of the proposal will focus on developing expertise in the developmental social neuroscience literature, computational methods that can be applied to developmental social neuroscience research, and mentorship skills to establish a diverse, inclusive independent research lab.

项目摘要不确定性是一种经常普遍，紧张的经历，在对他人的信念做出判断时会产生意图或情感（即模棱两可的社会情况）。过度不确定性会产生有害效果记忆，情绪以及身体和心理成果。然而，我们对社会的判断方式一无所知随着时间的推移，确定性形式，这些判断的神经电路以及这些判断如何有意义与非社会不确定性来源不同（例如计算，感知）。不确定性在每个发展阶段，但青少年和成年人的评价和对歧义的反应有所不同。两个都社会和非社交。传统的单变量神经影像学分析，该分析比较了平均幅度跨广阔神经区域的激活对特征的微妙模式差异无反应复杂的社会认知。新颖的多元技术，例如对象间相关性（ISC），应用于社会歧义的动态，功能丰富和生态涉及的来源对于理解至关重要社会认知的基本方面，但尚未应用于回答这些重要问题。 F99阶段：我提议的博士前项目使用了一种新型研究设计，成年参与者不断评估他们对特定社会（例如角色的无罪或内gui）和非社交（例如框架亮度）的确定性在观察FMRI期间的长形叙事视频刺激（即45分钟犯罪戏剧）的同时。这会产生同时录制的神经和行为数据的连续时间过程，可以通过ISC分析确定通常与规范成人之间不确定性判断形成有关的神经回路人群。界间神经行为同步可以强调社交和非社会确定性判断形成机制不同。定义规范性的成人神经不确定性反应提供了至关重要的与具有明显不确定性反应的脆弱人群进行比较，包括自闭症谱系，焦虑和情绪障碍。此阶段的培训包括有关计算方法相关的指导社会决策和神经发育理论的神经科学为K00阶段做准备。 K00阶段：此阶段通过将F99阶段研究设计应用于青少年来扩展我的博物前研究人群。这种方法可以确定成人和青少年通常依赖于独特的或类似的神经回路，以评估相同的刺激并为不确定性的主观指标提供信息（即行为评分）。青春期是对社交他人的强烈关注的标志。歧义的存在在此期间，社会压力源预测焦虑和抑郁的敏感性和成年期的严重性。因此，如何处理社会不确定性对以后工作的研究人员具有显着影响发展阶段。该提案的这一阶段的培训计划将着重于发展专业知识发展性社会神经科学文献，可以应用于发展的计算方法社会神经科学研究和指导技巧，以建立多样化的包容性独立研究实验室。