NAVBO Workshops at Vascular Biology 2015

2015 年血管生物学 NAVBO 研讨会

基本信息

批准号：
8911097
负责人：
Marsha W ROLLE
金额：
$ 3万
依托单位：
NORTH AMERICAN VASCULAR BIOLOGY ORG
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8911097
关键词：
Accounting Address Area Atherosclerosis Basic Science Biocompatible Materials Biology Biomedical Engineering Blood Vessels Cardiovascular Diseases Cardiovascular Pathology Cardiovascular Physiology Cell Communication Cell physiology Cells Chronic Kidney Failure Clinical Cods Collaborations Development Devices Diabetes Mellitus Disease Education Educational workshop Endothelial Cells Engineering Environment Extracellular Matrix Failure Fostering Funding Gene Expression Genetic Goals Growth Growth Factor Health Hematological Disease Hematopoietic Human Hypertension Immune System Diseases Industry Inflammatory International Investigation Ischemia Joints Knowledge Lymphatic vessel Malignant Neoplasms Massachusetts Mechanics Metabolic syndrome Mission Morphogenesis Natural regeneration Organ Outcome Pathology Pathway interactions Phenotype Physiology Postdoctoral Fellow Prevention strategy Principal Investigator Private Sector Regenerative Medicine Request for Applications Research Research Personnel Resort Retinal Diseases Role Scientist Signal Pathway Signal Transduction Stroke Therapeutic Tissue Engineering Translations Treatment Efficacy Vascular Diseases Vascular System Work abstracting base cancer therapy career cell type experience field study graduate student human disease improved in vivo intercellular communication interest meetings nervous system disorder new technology novel programs public health relevance repaired stem cell biology symposium tool treatment strategy vascular tissue engineering

项目摘要

DESCRIPTION (provided by applicant): NAVBO Workshops at Vascular Biology 2015 October 18-22, 2015 Resort and Conference Center at Hyannis, Massachusetts. Principal Investigators: Martin Schwartz and Marsha Rolle. Vascular biology has evolved over the past decade as a major cross-disciplinary field of study which impacts a wide number of major human diseases beyond the more "traditional" vessel wall pathologies, such as atherosclerosis and hypertension. Today, vascular biology also contributes to our understanding of diabetes, metabolic syndrome, chronic kidney disease, neurological disorders, stroke, hematological disorders, cancer and various immunological diseases. More importantly, advances in vascular biology have contributed to the development of many potential new therapies and preventive strategies, in addition to bioengineered devices and engineered replacement organs. However, despite many advances in our understanding of the roles of both soluble factors, cell-cell interactions, the extracellular matrix and microenvironment in vascular development, function and pathology, major aspects of the basic science are poorly understood and major translational opportunities await exploitation. Researchers have come to understand that the soluble regulatory factors, cell-cell interactions, extracellular matrix and mechanical forces collectively regulate key signaling pathways to determine cardiovascular physiology and pathology. Furthermore, developing an integrated understanding of these environmental regulatory inputs is critical for developing regenerative medicine approaches and vascular tissue engineered products for clinical use. This unique program will combine two workshops, one on signaling in the vascular system, the second on the biology and engineering of the extracellular matrix. It includes specific translational sessions and a pre-meeting specifically for trainees. Our aim is to provide a forum for basic and clinical researchers in these complementary areas of vascular biology, regenerative medicine, and bioengineering to interact, and to provide a superb forum for furthering the education and careers of trainees. The workshops will be interdisciplinary, allowing researchers in biology and engineering to come together in a common focus to address important issues in cardiovascular disease and regeneration. The program is characterized by the presentation of cutting edge research in areas including vascular morphogenesis, growth factor signaling, mechanotransduction, matrix remodeling and repair, matrix genetics and development, stem cell biology, and tissue engineering. We believe these topics are highly relevant to the NHLBI's mission to further our understanding and develop new tools to treat disease. In this application we request funds to partially support this interdisciplinary, international conference which will serve to bring together investigators from the academic and private sectors, post-doctoral fellows, and graduate students from diverse fields of study for four days of intense discussion and study. The conference will be held at the Resort and Conference Center at Hyannis on Cape Cod in Hyannis, Massachusetts from October 18-22, 2015.

描述（由申请人提供）：2015 年血管生物学 NAVBO 研讨会，2015 年 10 月 18 日至 22 日，马萨诸塞州海恩尼斯度假村和会议中心首席研究员：Martin Schwartz 和 Marsha Rolle 血管生物学在过去十年中已发展成为一个主要的交叉领域。学科研究领域，除了更“传统”的血管壁病理学（例如动脉粥样硬化和高血压）之外，还影响许多主要人类疾病。如今，血管生物学还有助于我们了解糖尿病、代谢综合征、慢性肾病、神经系统疾病、中风、血液系统疾病、癌症和各种免疫疾病。更重要的是，血管生物学的进步促进了许多潜在新疗法的开发。然而，尽管我们对可溶性因子、细胞间相互作用、细胞外基质和微环境在血管发育、功能和病理学中的作用的理解取得了许多进展，但血管发育、功能和病理学的主要方面。基础科学人们对可溶性调节因子、细胞间相互作用、细胞外基质和机械力知之甚少，主要的转化机会有待开发。此外，对这些环境调节输入的综合理解对于开发用于临床的再生医学方法和血管组织工程产品至关重要。这一独特的计划将结合两个研讨会，其中一个是关于信号传导的研讨会。血管系统，第二个关于细胞外基质的生物学和工程，它包括专门为学员准备的具体翻译课程和预会。为血管生物学、再生医学和生物工程这些互补领域的基础和临床研究人员提供了一个互动的论坛，并为进一步培训学员的教育和职业提供了一个极好的论坛。研讨会将是跨学科的，允许生物学和生物工程领域的研究人员进行交流。该项目的特点是展示血管形态发生、生长因子信号传导、机械传导、基质重塑和修复、基质遗传学和再生等领域的前沿研究。我们相信这些主题与 NHLBI 的使命高度相关，即进一步了解和开发治疗疾病的新工具。在此申请中，我们请求部分支持这次跨学科会议，该会议将有助于汇聚一堂。来自学术界和私营部门的研究人员、博士后研究员和来自不同研究领域的研究生四人会议将于 2015 年 10 月 18 日至 22 日在马萨诸塞州海恩尼斯科德角海恩尼斯度假村和会议中心举行。