The relationship between fMRI and patient-reported outcomes in chemotherapy-induced neuropathy:  A diversity supplement

功能磁共振成像与化疗引起的神经病变患者报告结果之间的关系：多样性补充

• 批准号: 10819004
• 负责人: Constance Margaret Johnson
• 金额: $ 19.79万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10819004
• 关键词: Acupressure; Anti-Inflammatory Agents; Attitude; Brain Injuries; Brief Pain Inventory; Cancer Patient; Cellular Phone; Clinical; Clinical Trials Design; Data; Data Analyses; Development; Dose; Ear; Educational process of instructing; Faculty; Foundations; Functional Magnetic Resonance Imaging; Goals; Individual; Manuscripts; Mentors; Modality; Nonpharmacologic Therapy; Pain; Participant; Patient Outcomes Assessments; Quality of life; Questionnaires; Research; Research Personnel; Resources; Scientist; Secure; Self Management; Sensory; Signal Transduction; Symptoms; Testing; Training; career; chemotherapy induced neuropathy; cytokine; data management; experience; follow-up; imaging biomarker; imaging study; improved; innovation; mobile application; opioid use; pain relief; parent grant; participant retention; recruit; side effect; treatment duration; Acupressure; Anti-Inflammatory Agents; Attitude; Brain Injuries; Brief Pain Inventory; Cancer Patient; Cellular Phone; Clinical; Clinical Trials Design; Data; Data Analyses; Development; Dose; Ear; Educational process of instructing; Faculty; Foundations; Functional Magnetic Resonance Imaging; Goals; Individual; Manuscripts; Mentors; Modality; Nonpharmacologic Therapy; Pain; Participant; Patient Outcomes Assessments; Quality of life; Questionnaires; Research; Research Personnel; Resources; Scientist; Secure; Self Management; Sensory; Signal Transduction; Symptoms; Testing; Training; career; chemotherapy induced neuropathy; cytokine; data management; experience; follow-up; imaging biomarker; imaging study; improved; innovation; mobile application; opioid use; pain relief; parent grant; participant retention; recruit; side effect; treatment duration

Summary of Parent Grant (R01CA245054) Chemotherapy induced neuropathy (CIN) is a severe side effect that impacts greater than 60% of cancer patients. CIN impacts treatment duration and dosing, functional mobility, and quality of life. This proposal examines the effect of auricular point acupressure (APA) as an innovated solution for CIN. APA utilizes a non-invasive, active modality of treatment stimulating points on ear to improve CIN symptoms. Utilizing a mobile application on smartphones, this project teaches participants how to stimulate their ears for three minutes, 3 times a day to alleviate pain. Given limited understanding of the mechanism of pain relief, participants will complete multiple questionnaires: Quantitative Sensory Test, Revised Brief Pain Inventory-CIN, PROMIS- 29, Opioid Use, Experience and Attitude, and Demographic data. Additionally, imaging studies and biomarkers will be obtained. Functional MRI (fMRIs) will obtain pre-, post-, and follow-up APA evoked signal changes and pro- and anti- inflammatory cytokines will be collected. The goal of this study is to ascertain the efficacy of APA as a self-managed, adjunctive therapy to enhance CIN management, through understanding the underlying mechanisms of APA on CIN.

父母赠款的摘要（R01CA245054） 化学疗法诱导的神经病（CIN）是严重的副作用，影响大于60％ 癌症患者。 CIN影响治疗时间和剂量，功能性动机以及质量 生活。该提案探讨了耳角腔（APA）作为创新的效果 CIN解决方案。 APA利用了无创的，主动的治疗方法刺激点 可改善CIN症状的耳朵。使用智能手机上的移动应用程序，该项目 教参与者如何刺激他们的耳朵三分钟，每天3次以减轻 疼痛。鉴于对缓解疼痛机制的理解有限，参与者将完成 多个问卷：定量感官测试，修订的简短疼痛库存cin，promis-- 29，阿片类药物的使用，经验和态度以及人口统计数据。另外，成像研究 并将获得生物标志物。功能性MRI（FMRIS）将获得前，后和随访 将收集APA引起的信号变化以及促炎性细胞因子。这 这项研究的目标是确定APA作为一种自我管理的辅助疗法的功效 通过了解CIN上APA的基本机制来增强CIN管理。