The relationship between fMRI and patient-reported outcomes in chemotherapy-induced neuropathy:  A diversity supplement

功能磁共振成像与化疗引起的神经病变患者报告结果之间的关系：多样性补充

• 批准号: 10819004
• 负责人: Constance Margaret Johnson
• 金额: $ 19.79万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10819004
• 关键词: Acupressure; Anti-Inflammatory Agents; Attitude; Brain Injuries; Brief Pain Inventory; Cancer Patient; Cellular Phone; Clinical; Clinical Trials Design; Data; Data Analyses; Development; Dose; Ear; Educational process of instructing; Faculty; Foundations; Functional Magnetic Resonance Imaging; Goals; Individual; Manuscripts; Mentors; Modality; Nonpharmacologic Therapy; Pain; Participant; Patient Outcomes Assessments; Quality of life; Questionnaires; Research; Research Personnel; Resources; Scientist; Secure; Self Management; Sensory; Signal Transduction; Symptoms; Testing; Training; career; chemotherapy induced neuropathy; cytokine; data management; experience; follow-up; imaging biomarker; imaging study; improved; innovation; mobile application; opioid use; pain relief; parent grant; participant retention; recruit; side effect; treatment duration

Summary of Parent Grant (R01CA245054) Chemotherapy induced neuropathy (CIN) is a severe side effect that impacts greater than 60% of cancer patients. CIN impacts treatment duration and dosing, functional mobility, and quality of life. This proposal examines the effect of auricular point acupressure (APA) as an innovated solution for CIN. APA utilizes a non-invasive, active modality of treatment stimulating points on ear to improve CIN symptoms. Utilizing a mobile application on smartphones, this project teaches participants how to stimulate their ears for three minutes, 3 times a day to alleviate pain. Given limited understanding of the mechanism of pain relief, participants will complete multiple questionnaires: Quantitative Sensory Test, Revised Brief Pain Inventory-CIN, PROMIS- 29, Opioid Use, Experience and Attitude, and Demographic data. Additionally, imaging studies and biomarkers will be obtained. Functional MRI (fMRIs) will obtain pre-, post-, and follow-up APA evoked signal changes and pro- and anti- inflammatory cytokines will be collected. The goal of this study is to ascertain the efficacy of APA as a self-managed, adjunctive therapy to enhance CIN management, through understanding the underlying mechanisms of APA on CIN.

家长补助金摘要（R01CA245054） 化疗引起的神经病变 (CIN) 是一种严重的副作用，影响超过 60% 的癌症患者。 CIN 影响治疗持续时间和剂量、功能活动性和治疗质量 生活。该提案研究了耳穴穴位按压 (APA) 作为一种创新疗法的效果。 CIN 的解决方案。 APA 采用非侵入性、主动的刺激穴位治疗方式 耳部改善CIN症状。该项目利用智能手机上的移动应用程序 教参与者如何刺激耳朵三分钟，每天3次，以缓解 疼痛。鉴于对疼痛缓解机制的了解有限，参与者将完成 多项问卷：定量感官测试、修订版简短疼痛量表-CIN、PROMIS- 29、阿片类药物的使用、经验和态度以及人口统计数据。此外，影像学研究 并获得生物标志物。功能性 MRI (fMRI) 将获得术前、术后和随访数据 APA 诱发的信号变化以及促炎和抗炎细胞因子将被收集。这 本研究的目的是确定 APA 作为自我管理辅助疗法的功效 通过了解 APA 对 CIN 的底层机制，加强 CIN 管理。