The National Center for In-situ Tomographic Ultramicroscopy (NCITU)

国家原位断层超显微术中心 (NCITU)

• 批准号: 10818768
• 负责人: Jeffrey S Kieft
• 金额: $ 35万
• 依托单位: NEW YORK STRUCTURAL BIOLOGY CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818768
• 关键词: Cells; Cryo-electron tomography; Electron Microscopy; Equipment; Funding; In Situ; New York; Preparation; Qualifying; Sampling; Services; Specimen; Time; Training; Visualization; Work; computing resources; equipment acquisition; instrument; light microscopy; method development; structural biology; tomography; Cells; Cryo-electron tomography; Electron Microscopy; Equipment; Funding; In Situ; New York; Preparation; Qualifying; Sampling; Services; Specimen; Time; Training; Visualization; Work; computing resources; equipment acquisition; instrument; light microscopy; method development; structural biology; tomography

Project Summary/Abstract The National Center for In-situ Tomographic Ultramicroscopy (NCITU), based at the New York Structural Biology Center, provides user access and service towards preparing specimens for direct visualization of macromolecular associations and organization, particularly in native cells. A highly qualified technical team provides direct hands-on service, guidance, and assistance to ensure that samples and grids are prepared with the highest quality and in the shortest time possible. We are requesting funds to purchase equipment to upgrade and expand our computational resources and upgrade our Thermo Fisher Scientific (TFS) Aquilos2 for correlative light and electron microscopy (CLEM) work. These upgrades will benefit all users of NCITU by increasing the capability and capacity of these instruments.

项目摘要/摘要 位于纽约的国家原位断层扫描超显镜（NCITU）中心（NCITU） 结构生物学中心，为用户访问和服务提供准备标本 直接可视化大分子关联和组织，特别是在天然细胞中。 一个高素质的技术团队为直接的动手服务，指导和帮助 确保以最高质量和最短时间制备样品和网格 可能的。 我们要求资金购买设备以升级和扩展我们的计算 资源并升级我们的Thermo Fisher Scientific（TFS）Aquilos2，以进行相关光和 电子显微镜（CLEM）工作。这些升级将通过增加NCITU的所有用户 这些工具的能力和能力。