Administrative Supplement: 1/2 Trans-ancestry genomic analysis of obsessive-compulsive disorder

行政补充：强迫症的1/2跨血统基因组分析

• 批准号: 10818832
• 负责人: James Joseph Crowley
• 金额: $ 7.13万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10818832
• 关键词: Acceleration; Administrative Supplement; African ancestry; Anhedonia; Asian; Cognition; Communities; Consensus; Country; Data; Data Analyses; Data Analytics; Data Collection; Deposition; Diagnosis; Discrimination; Environmental Risk Factor; Equity; Future; Genetic; Genomics; Goals; Healthcare Systems; Individual; Latin American; Latinx population; Measurement; Measures; Mental Health; Mental disorders; National Institute of Mental Health; Obsessive compulsive behavior; Obsessive-Compulsive Disorder; Phenotype; Population; Population Heterogeneity; Procedures; Process; Property; Psychometrics; Reproducibility; Resources; Risk; Site; Standardization; Symptoms; Underrepresented Populations; cognitive function; cohort; data archive; disease phenotype; instrument; member; phenotypic data; psychogenetics; social stigma; suicidal; trait

PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic harmonization efforts across APN members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. Through a consensus process of APN members, measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma were selected for harmonization across ongoing studies. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries.

项目摘要 该项目实现了祖先人口网络的主要目标（APN； PAR-20-026和PAR-20-- 027），即促进APN成员之间的测量和数据分析协调工作以增强 严格且可重复性，并为网络成员和科学界创造资源。通过一个 APN成员的共识过程，Anhedonia的测量，认知，强迫症症状， 在正在进行的研究中选择自杀和歧视/污名来协调。这些 将在代表亚洲，拉丁语的估计27,500个人中收集统一的措施 美国和非洲祖先跨越了15个国家。

项目成果

Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know.

• DOI: 10.1016/j.psc.2022.11.003
• 发表时间: 2023-03
• 期刊: PSYCHIATRIC CLINICS OF NORTH AMERICA
• 影响因子: 1.7
• 作者: Crowley, James J.

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.

拉丁美洲跨祖先强迫症基因组学倡议 (LATINO)：研究方案。

• DOI: 10.1101/2023.02.23.23286373
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Crowley,JamesJ;Cappi,Carolina;Ochoa-Panaifo,MarcosE;Frederick,ReneeM;Kook,Minjee;Wiese,AndrewD;Rancourt,Diana;Atkinson,ElizabethG;Giusti-Rodriguez,Paola;Anderberg,JaceyL;LatinAmericanTrans-ancestryINitiativeforOCDgenomics(
• 通讯作者: LatinAmericanTrans-ancestryINitiativeforOCDgenomics(