Diversity Supplement to DP2AT011965

DP2AT011965 的多样性补充

基本信息

批准号：
10818161
负责人：
Amber L Alhadeff
金额：
$ 8.96万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10818161
关键词：
ART protein Address Anatomy Animal Model Award Behavior Behavioral Body Weight Body Weight decreased Brain Calcium Central Nervous System Complex Cues Data Development Doctor of Medicine Doctor of Philosophy Dopamine Eating Eating Behavior Environment Exposure to Feeding behaviors Fiber Food Food Interactions Food Preferences Funding Generations Goals Health Hunger Hyperphagia Hypothalamic structure Imaging Techniques Individual Knowledge Latinx Learning Low income Maps Mentors Mentorship Mexican Americans Midbrain structure Modernization Monitor Motivation Mus Neural Pathways Neurons Neurosciences Nutrient Obese Mice Obesity Operative Surgical Procedures Pathway interactions Pattern Photometry Physicians Physiology Process Publications Research Rewards Satiation Science Scientist Sensory Signal Pathway Signal Transduction Smell Perception Stream Talents Taste Perception Techniques Technology Therapeutic Thinness Training Underrepresented Populations Underrepresented Students United States United States National Institutes of Health Weight Gain Work Writing awake behavior influence billboard career career development college comorbidity demographics dopaminergic neuron experience experimental study falls feeding food environment high school in vivo in vivo monitoring matriculation meetings member neural neural circuit neural network novel novel strategies obesity development obesogenic pharmacologic posters programs sensory integration sensory stimulus skills two photon microscopy undergraduate student

项目摘要

PROJECT SUMMARY Our modern food environment, with its widespread availability of energy-dense, palatable foods and associated cues, is thought to interact with our physiology to promote food intake. This has contributed to the drastic increase in obesity in the United States over the past several decades. However, most pharmacological weight loss strategies target satiation pathways, not sensory pathways, and therefore may be less effective at eliminating effects of environmental/sensory cues on food intake. Here we propose to take a novel approach to understanding the drive to eat by examining the neural integration of sensory and nutritive food signals. First, we will create sensory “engrams” – functional maps of neurons activated by discrete sensory stimuli – and determine how activating or inhibiting these circuits can influence food preference. Next, we will monitor calcium dynamics in individual neurons to reveal the activity patterns that integrate sensory and nutritive information in the brain across different body weights. These studies will reveal fundamental principles of how food information is integrated in the brain to drive feeding behavior, revealing new targets for the development of obesity therapeutics. We are applying for an additional year of supplemental funding to enable Ms. Alexandra Vargas, a first-generation, low income, Latinx U.S. citizen to continue to perform research on the neural underpinnings of feeding behavior, add new complementary neuroscience techniques to her technical repertoire, and further develop receive writing, presentation, and networking skills. In this second year, Ms. Vargas will also gain valuable mentorship experience, as she will help with training and mentoring Alhadeff lab high school and undergraduate students from underrepresented backgrounds as they embark on their own research journeys. We believe that this additional year of comprehensive technical, career development, and mentorship training will give Ms. Vargas a competitive edge as she applies for M.D./Ph.D. programs in neuroscience to start in fall 2024. Overall, this funding will facilitate the career of Ms. Vargas, an extremely impressive and talented rising scientist, giving her the opportunity to make major advances in the fields of neuroscience and obesity while increasing diversity in NIH health-related research.

项目摘要我们的现代食品环境，其能量浓密，可口的食物及其相关性提示，与我们的生理学相互作用以促进食物的摄入量。在过去的几十年中，美国的肥胖症。策略针对满意度途径，而不是感觉途径，因此可能较少消除环境/感觉线索对食物摄入的影响。通过检查感觉和营养食品信号的神经整合，了解饮食的动力。我们将创建感官“英语” - 由离散感官刺激激活的神经元的功能图 - 和确定激活或抑制电路如何影响食物偏好。单个神经元中的动力学，以揭示将感觉和营养信息整合到中的活动模式这些研究的大脑将是食物信息的基本原则被整合到大脑中以推动喂养行为，陶醉于肥胖的发展目标治疗学。第一代，低收入，拉丁裔美国公民继续进行神经基础喂食行为，在其技术撰稿中添加新的编译神经科学技术，然后进一步在第二年获得写作，演示和网络技能。宝贵的指导经验，因为她将帮助培训和指导Alhadefffffffffffffffffffffffff f 来自代表性不足的背景的本科生在进行自己的研究之旅时。我们认为，这一额外的全年技术，职业发展和指导培训一年将为M.D./ph.d的Shesh提供竞争优势。 2024年。总的来说，这有助于瓦尔加斯女士的职业科学家，让她有机会在神经科学和肥胖领域取得重大进步，而 NIH健康相关研究的多样性增加。