Diversity Supplement to DP2AT011965

DP2AT011965 的多样性补充

• 批准号: 10818161
• 负责人: Amber L Alhadeff
• 金额: $ 8.96万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818161
• 关键词: ART protein; Address; Anatomy; Animal Model; Award; Behavior; Behavioral; Body Weight; Body Weight decreased; Brain; Calcium; Central Nervous System; Complex; Cues; Data; Development; Doctor of Medicine; Doctor of Philosophy; Dopamine; Eating; Eating Behavior; Environment; Exposure to; Feeding behaviors; Fiber; Food; Food Interactions; Food Preferences; Funding; Generations; Goals; Health; Hunger; Hyperphagia; Hypothalamic structure; Imaging Techniques; Individual; Knowledge; Latinx; Learning; Low income; Maps; Mentors; Mentorship; Mexican Americans; Midbrain structure; Modernization; Monitor; Motivation; Mus; Neural Pathways; Neurons; Neurosciences; Nutrient; Obese Mice; Obesity; Operative Surgical Procedures; Pathway interactions; Pattern; Photometry; Physicians; Physiology; Process; Publications; Research; Rewards; Satiation; Science; Scientist; Sensory; Signal Pathway; Signal Transduction; Smell Perception; Stream; Talents; Taste Perception; Techniques; Technology; Therapeutic; Thinness; Training; Underrepresented Populations; Underrepresented Students; United States; United States National Institutes of Health; Weight Gain; Work; Writing; awake; behavior influence; billboard; career; career development; college; comorbidity; demographics; dopaminergic neuron; experience; experimental study; falls; feeding; food environment; high school; in vivo; in vivo monitoring; matriculation; meetings; member; neural; neural circuit; neural network; novel; novel strategies; obesity development; obesogenic; pharmacologic; posters; programs; sensory integration; sensory stimulus; skills; two photon microscopy; undergraduate student

PROJECT SUMMARY Our modern food environment, with its widespread availability of energy-dense, palatable foods and associated cues, is thought to interact with our physiology to promote food intake. This has contributed to the drastic increase in obesity in the United States over the past several decades. However, most pharmacological weight loss strategies target satiation pathways, not sensory pathways, and therefore may be less effective at eliminating effects of environmental/sensory cues on food intake. Here we propose to take a novel approach to understanding the drive to eat by examining the neural integration of sensory and nutritive food signals. First, we will create sensory “engrams” – functional maps of neurons activated by discrete sensory stimuli – and determine how activating or inhibiting these circuits can influence food preference. Next, we will monitor calcium dynamics in individual neurons to reveal the activity patterns that integrate sensory and nutritive information in the brain across different body weights. These studies will reveal fundamental principles of how food information is integrated in the brain to drive feeding behavior, revealing new targets for the development of obesity therapeutics. We are applying for an additional year of supplemental funding to enable Ms. Alexandra Vargas, a first-generation, low income, Latinx U.S. citizen to continue to perform research on the neural underpinnings of feeding behavior, add new complementary neuroscience techniques to her technical repertoire, and further develop receive writing, presentation, and networking skills. In this second year, Ms. Vargas will also gain valuable mentorship experience, as she will help with training and mentoring Alhadeff lab high school and undergraduate students from underrepresented backgrounds as they embark on their own research journeys. We believe that this additional year of comprehensive technical, career development, and mentorship training will give Ms. Vargas a competitive edge as she applies for M.D./Ph.D. programs in neuroscience to start in fall 2024. Overall, this funding will facilitate the career of Ms. Vargas, an extremely impressive and talented rising scientist, giving her the opportunity to make major advances in the fields of neuroscience and obesity while increasing diversity in NIH health-related research.

项目摘要 我们的现代食品环境，其宽度可提供能量密集，可口的食物和相关的食物 线索被认为与我们的生理学相互作用以促进食物摄入量。这导致了急剧增加 在过去的几十年中，美国的肥胖症。但是，大多数药物减肥 策略针对满意度途径，而不是感官途径，因此在消除方面可能不太有效 环境/感觉线索对食物摄入的影响。在这里，我们建议采取一种新颖的方法 通过检查感觉和营养食品信号的神经整合，了解饮食的动力。第一的， 我们将创建感官“ engrams” - 由离散感觉刺激激活的神经元的功能图 - 和 确定激活或抑制这些电路如何影响食物偏好。接下来，我们将监视钙 单个神经元中的动力学，以揭示在感官和营养信息中的活性模式 大脑跨越不同的体重。这些研究将揭示食物信息如何的基本原理 集成在大脑中以推动进食行为，揭示了肥胖发展的新目标 疗法。我们正在申请额外的补充资金，以启用Alexandra Vargas女士 第一代，低收入，拉丁裔美国公民继续对 喂养行为，在其技术曲目中添加新的完整神经科学技术，并进一步 发展接受写作，演示和网络技能。在第二年，瓦尔加斯女士也将获得 价值精通经验，因为她将帮助培训和心理训练Alhadeff Lab High School和 来自代表性不足的背景的本科生在进行自己的研究之旅时。 我们相信，这一额外的全年技术，职业发展和精神培训的一年 将为Vargas女士提供竞争优势，因为她适用于M.D./ph.d。神经科学的程序从秋天开始 2024年。总的来说，这笔资金将有助于瓦尔加斯女士的职业，这是一个非常令人印象深刻且才华横溢的复活 科学家，让她有机会在神经科学和肥胖领域取得重大进步，同时 NIH健康相关研究的多样性增加。