Preparing for Implementation of the ATN CARES Evidence-Based Intervention Package for PrEP Uptake and Syndemic Factors among Youth

准备实施针对青少年 PrEP 吸收和流行病因素的 ATN CARES 循证干预方案

• 批准号: 10818271
• 负责人: Steven J Shoptaw
• 金额: $ 23.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818271
• 关键词: AIDS prevention; Acceleration; Address; Adherence; Adopted; Adoption; African American; Age; Behavior Therapy; Black race; California; Caring; Case Manager; Client; Clinic; Collaborations; Communities; Community Health Aides; Complex; Consolidated Framework for Implementation Research; Data Analyses; Data Collection; Dedications; Development; Diffuse; Dissemination and Implementation; Economics; Effectiveness of Interventions; Elements; Epidemic; Evidence based intervention; Evidence based practice; Failure; Food; Foundations; Frontline worker; Future; HIV; HIV risk; HIV-infected adolescents; Health; Health Educators; Housing; Human Resources; Hybrids; Internet; Intervention; Interview; Latinx; Libraries; Link; Literature; Los Angeles; Manuals; Measures; Medicine; Mental Health; Methods; Minor; Modality; Monitor; Outcome Measure; Pathway interactions; Persons; Phase; Policies; Preparation; Prevention; Protocols documentation; Provider; Public Health; Quality of life; Randomized; Reduce health disparities; Research; Research Project Grants; Risk; Role; Service delivery model; Services; Sexual Health; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Sexually Transmitted Diseases; Slide; Social Behavior; Structure; Surveys; System; Technology; Testing; Text Messaging; Training; Update; Viral; Youth; acceptability and feasibility; aged; automated text message; chatbot; children of color; community engagement; cost; design; effectiveness trial; effectiveness/implementation study; effectiveness/implementation trial; ethnic minority; flexibility; follow-up; high risk; implementation design; implementation intervention; implementation measures; implementation outcomes; implementation research; implementation science; implementation strategy; implementation study; infection risk; innovation; interest; minority children; peer; peer support; pre-exposure prophylaxis; preference; prevent; preventive intervention; programs; racial minority; scale up; service engagement; social; social determinants; staff intervention; substance use; syndemic; telehealth; theories; therapy design; uptake

Project Summary/Abstract America’s increasing HIV epidemic among youth aged 12-24 and our concurrent failure to identify, link to care, sustain support services and achieve viral suppression among youth living with HIV suggests the need to scale-up and sustain community-based strategies to leverage gateways and settings where high risk and infected youth can be engaged in HIV prevention and treatment. Sexual and gender minority and racial/ethnic minority youth in the U.S. are at disproportionate risk of acquiring HIV due to syndemic factors and low PrEP uptake, yet effective and scalable interventions for youths remain limited. This study will accelerate the implementation of Adolescent HIV Medicine Trials Network (ATN) Protocol 149 Optimizing the HIV Prevention Continuum for Youth intervention package that was developed to be responsive to the needs and preferences of implementers and youth. This study proposes to develop with community partners implementation support strategies to prepare for a hybrid type-2 effectiveness-implementation study to test implementation strategies and validate intervention effectiveness in a real-world replication study. Phase 1 Qualitative Interviews and Networking. Interested parties (stakeholders) from Southern California public health and frontline HIV prevention organizations will be interviewed, including agency leaders (n=10) and frontline prevention workers (n=30). The Consolidated Framework for Implementation Research (CFIR) will guide semi-structured interviews and rapid qualitative data analyses for exploring qualitatively the barriers, facilitators, preferences, and opportunities for implementation of the ATN 149 interventions for two primary strategies: 1) agency staff training and delivery by frontline workers; or 2) direct-to-youth delivery by dedicated program staff with reciprocal agency linkages. Phase 2: Intervention Package Update & Type 2 Hybrid Implementation-Effectiveness Trial Preparation: Phase 1 will inform a plan for updating and adapting the intervention package based on one or both implementation strategies. Implementing partners from Phase 1 will be engaged in collaboratively adapting and updating protocols, training materials, text- message libraries, peer support forum, and the mobile-web intervention management system for text-messaging and coaching implementation support.

项目摘要/摘要 在12-24岁的青年中，美国的艾滋病毒流行不断增加，我们同时未能 确定，链接到护理，维持支持服务并在生活中实现病毒抑制 艾滋病毒提出需要扩大和维持基于社区的策略以利用艾滋病毒以利用艾滋病毒 高风险和感染青年可以从事艾滋病毒预防的门户和环境 和治疗。美国的性和性别少数民族以及美国的种族/少数民族青年在 由于联合因素和摄入量低的辛迪姆因素而获得艾滋病毒的不成比例风险，但 对年轻人的有效和可扩展的干预措施仍然有限。这项研究将加速 青少年艾滋病毒医学试验网络（ATN）协议的实施149优化 艾滋病毒预防连续性针对青年干预套件的响应迅速 满足实施者和青年的需求和偏好。这项研究的提案要与 社区合作伙伴实施支持策略，为混合类型2做准备 有效实施研究以测试实施策略并验证干预 在一项现实世界复制研究中的有效性。 第1阶段的定性访谈和网络。有兴趣的各方（利益相关者） 南加州的公共卫生和前线艾滋病毒预防组织将接受采访， 包括代理领导者（n = 10）和前线预防工人（n = 30）。合并 实施研究框架（CFIR）将指导半结构化访谈和快速 定性数据分析，用于定性地探索障碍，促进者，偏好和 实施两种主要策略的ATN 149干预措施的机会：1） 一线工人的代理人员培训和交付；或2）通过专用的直接交付 具有相互代理联系的计划人员。 第2阶段：干预软件包更新和类型2混合实施效应 试用准备：第1阶段将为更新和调整干预的计划提供信息 基于一种或两个实施策略的包装。从第1阶段实施合作伙伴 将参与协作适应和更新协议，培训材料，文本 - 消息库，同行支持论坛和移动WEB干预管理系统 用于文字传达和教练实施支持。