Equipment Supplement- Prolonged duration and triggered local anesthesia

设备补充-延长持续时间并触发局部麻醉

• 批准号: 10798980
• 负责人: Daniel S Kohane
• 金额: $ 15.86万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798980
• 关键词: Administrative Supplement; Award; Biodegradation; Consumption; Drug Delivery Systems; Equipment; Funding; Gel Chromatography; Institution; Local anesthesia; Modification; Molecular Weight; Monitor; National Institute of General Medical Sciences; Performance; Pharmaceutical Preparations; Polymers; Reaction Time; Research; Route; Sampling; System; Techniques; Time; Travel; chemical reaction; chemical synthesis; cost; design; hydrophilicity; in vivo; nanoparticle

Summary Many drug delivery systems for prolonged or triggerable local anesthesia are composed of polymers. Polymer molecular weight is a crucial parameter determining polymer function, as well as synthesis. Gel permeation chromatography is the gold standard way to determine molecular weight. GPC will allow us to determine exactly what the products of our syntheses are, whether these are polymers, block polymers, polymer-drug conjugates, polymer modification, and even nanoparticles. (All of these have been studied under the present R35.) GPC is also useful for chemical reaction monitoring in real time to determine whether we obtain the desired product for sustained and/or triggered release systems and to optimize the chemical synthesis routes. GPC is also the standard way to study polymer biodegradation – an important determinant of polymer function in vivo. GPC is a technique that we have frequently used in our research funded by NIGMS. Access to GPC has been a serious bottleneck to our research since there is only one at our institution and it is used for hydrophilic polymers only and is heavily oversubscribed. Using other institutions’ GPC is costly, time consuming (travel), suboptimal for sample stability, and impractical for real time reaction monitoring. We are therefore applying for an administrative supplement to purchase a GPC for our lab.

概括 许多用于长时间或可触发局部麻醉的药物输送系统由 聚合物分子量是确定聚合物功能的关键参数，如 以及合成。凝胶渗透色谱法是确定的黄金标准方法 分子量。 GPC将使我们能够准确确定合成产品的产品 是，它们是否是聚合物，嵌段聚合物，聚合物 - 药物缀合物，聚合物 修改，甚至是纳米颗粒。 （所有这些都在目前的R35下进行了研究。） GPC也可用于实时化学反应监测，以确定我们是否获得 持续和/或触发释放系统的所需产品，并优化化学物质 综合路由。 GPC也是研究聚合物生物降解的标准方法 - 重要的 在体内聚合物功能的决定因素。 GPC是我们经常在我们的 由Nigms资助的研究。进入GPC一直是我们研究的严重瓶颈 由于我们机构只有一个，仅用于亲水性聚合物，并且是 大量订购。使用其他机构的GPC昂贵，耗时（旅行）， 次优的样品稳定性，对于实时反应监测不切实际。我们是 因此，申请行政补充剂为我们的实验室购买GPC。

项目成果

Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel.

• DOI: 10.1038/s41551-021-00793-y
• 发表时间: 2021-09
• 期刊: Nature biomedical engineering
• 影响因子: 28.1
• 作者: Ji T;Li Y;Deng X;Rwei AY;Offen A;Hall S;Zhang W;Zhao C;Mehta M;Kohane DS
• 通讯作者: Kohane DS

Enhancement of single upconversion nanoparticle imaging by topologically segregated core-shell structure with inward energy migration.

• DOI: 10.1038/s41467-022-33660-8
• 发表时间: 2022-10-07
• 期刊: Nature communications
• 影响因子: 16.6

Corrigendum to "Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165" [Biomaterials 77(2016) 130-138].

“C-6OH 硫酸化透明质酸与 VEGF165 血管生成异构体的选择性结合”的勘误表 [Biomaterials 77(2016) 130-138]。

• DOI: 10.1016/j.biomaterials.2024.122501
• 发表时间: 2024
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Lim,Dong-Kwon;Wylie,RyanG;Langer,RobertS;Kohane,DanielS
• 通讯作者: Kohane,DanielS

Keeping Nanomedicine on Target.

• DOI: 10.1021/acs.nanolett.0c04638
• 发表时间: 2021-01-13
• 期刊: Nano letters
• 影响因子: 10.8
• 作者: Zhang W;Kohane DS
• 通讯作者: Kohane DS

Synergy in Nanomedicine: What It Is Not, and What It Might Be.

• DOI: 10.1021/acs.nanolett.1c01894
• 发表时间: 2021-07-14
• 期刊: Nano letters
• 影响因子: 10.8
• 作者: Staffa SJ;Kohane DS;Zurakowski D
• 通讯作者: Zurakowski D