A Neuroecological Approach to Examining the Effects of Early Life Adversity on Adolescent Drug Use Vulnerabilities Using the ABCD Dataset

使用 ABCD 数据集检查早期生活逆境对青少年吸毒脆弱性影响的神经生态学方法

• 批准号: 10803675
• 负责人: Assaf Oshri
• 金额: $ 62.5万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10803675
• 关键词: Address; Adolescence; Adolescent; Affect; Age; Attenuated; Behavior; Behavioral; Biological Markers; Biological Models; Brain; Breeding; Clinical; Cognitive; Collaborations; Communication; Communities; Data; Data Set; Decision Making; Development; Dimensions; Discrimination; Drug Addiction; Drug Modelings; Drug abuse; Drug usage; Ecology; Ecosystem; Emotional; Emotions; Ethnic Origin; Ethnic Population; Etiology; Exhibits; Exposure to; Family; Family dynamics; Growth; Heterogeneity; Human Biology; Impulsivity; Individual Differences; Informal Social Control; Intervention; Investigation; Link; Measurement; Measures; Mediating; Mediator; Minority; Modeling; Neurobiology; Neurocognitive; Neurosciences; Pathway interactions; Pattern; Persons; Pharmaceutical Preparations; Prevention; Prevention program; Process; Psychometrics; Race; Recording of previous events; Regulation; Research; Rest; Rewards; Risk; Risk Assessment; Risk Behaviors; Risk Factors; Risk Taking; Role; Schools; Science; Shapes; Short-Term Memory; Social Environment; Specificity; Statistical Models; Stress; Subgroup; System; Systems Theory; Techniques; Testing; Time; Youth; addiction; adolescent drug use; cognitive control; cognitive development; cognitive neuroscience; contextual factors; cultural values; drug development; drug misuse; drug use behavior; drug use vulnerability; early life adversity; ethnic identity; family influence; improved; innovation; intervention program; knowledge base; longitudinal dataset; minority children; multilevel analysis; neural; neurobehavioral; neurodevelopment; neuroimaging; peer; preventive intervention; protective factors; psychosocial; public health research; racial population; resilience; response; social; social culture; stressor; theories

Project Summary Early life adversity (ELA) is a multidimensional and potent risk factor for neurocognitive risk, downstream drug use vulnerabilities, and adolescent drug use and misuse. The effects of ELA on youth’s drug use risk depend on multiple dynamic family, peer, school, community, and sociocultural risk and protective contexts. Yet, a significant knowledge base is missing to further our understanding of the contexts in which neural biomarkers affect drug risk vulnerabilities and behaviors in adolescence. Emerging research and theory implicate neuroregulatory systems that underpin emotion and behavioral regulation as a powerful focus for adolescent drug use risk investigations. We focus on individual differences in neuroregulatory systems whereby cognitive control networks become more effective over time in modulating emotion processing networks, including the emotion/salience and reward salience networks. According to this dual system view, a neuroregulatory imbalance between the socioemotional network (or ERSN, comprised of the emotional, reward, and salience networks) and CCN ushers in diminished self-regulation abilities that underlie drug risk behaviors in adolescence. This developmental mechanism and subsequent risk behaviors may be differentially affected by youth’s dimensional stress. Extant developmental studies have cataloged psychosocial risk and protective processes that moderate the impact of ELA and the development of drug use vulnerabilities in adolescence. Yet ecological approaches remain rare in neuroscience approaches. Using a developmental ecological neuroscience approach, we propose to investigate neurocognitive mechanisms that mediate, and the contextual factors that moderate, the effect of ELA on drug-related vulnerabilities and drug use. We will focus on the impact of ELA on developmental changes in functional activation and communication (i.e., functional connectivity; FC) between the ERSN and CCN networks and its mechanistic role in leading to adolescent drug use vulnerabilities and later drug use. We propose to use a large, longitudinal dataset: the Adolescent Brain Cognitive Development Study (ABCD; N=11,883; ages 9-10 at baseline and 11.5-12.5 at wave 6). We aim to test (a) the developmental cognitive mechanisms that mediate the effect of ELA on drug use vulnerabilities and attendant drug use and misuse (b) the moderating influence of family, peer, school, community, and sociocultural contexts on the neurocognitive processes that lead to drug use vulnerabilities. Modeling multilevel latent change in ecological, behavioral, and neuroimaging data is critical to further the precision and specificity of developmental models and preventative intervention programs for drug addiction resilience in adolescence.

项目摘要 早期逆境（ELA）是神经认知风险的多维和潜在危险因素，下游 药物使用脆弱性以及青少年的吸毒和滥用。 ELA对青年使用风险的影响 取决于多个动态家庭，同伴，学校，社区和社会文化风险以及受保护的环境。 然而，缺少一个重要的知识基础，以进一步了解中性的环境 生物标志物会影响青少年的药物风险脆弱性和行为。 新兴的研究和理论暗示了基于情感和行为的神经调节系统 监管是青春期药物使用风险调查的强大重点。我们专注于个体差异 神经调节系统，随着时间的流逝，认知控制网络变得更加有效 情绪处理网络，包括情感/显着性和奖励显着​​性网络。据此 双重系统视图，社会情感网络之间的神经调节失衡（或ERSN，包括 情感，奖励和显着网络）和CCN在自我调节能力上的降低。 青少年的药物风险行为基础。这种发展机制和随后的风险行为 可能会受到青年人的尺寸压力的不同影响。现存的发展研究已分类 心理社会风险和受保护的过程，这些过程适应ELA的影响和毒品使用的发展 青少年的脆弱性。然而，在神经科学方法中，生态方法仍然很少。使用 发育生态神经科学方法，我们建议研究神经认知机制 ELA对与药物有关的脆弱性和药物的影响以及中等因素的中间因素 使用。我们将专注于ELA对功能激活和通信发展变化的影响 （即功能连接； FC）ERSN和CCN网络之间的机械作用 青少年药物使用脆弱性和后来的药物使用。 我们建议使用大型的纵向数据集：青少年脑认知发展研究 （ABCD; n = 11,883;在基线时为9-10岁，在第6波时为11.5-12.5）。我们旨在测试（a）发展 介导ELA对药物使用脆弱性和随之而来的吸毒和使用的认知机制 滥用（b）家庭，同伴，学校，社区和社会文化背景的调节影响 导致药物使用漏洞的神经认知过程。建模生态学多级潜在变化， 行为和神经影像数据对于进一步的发展模型的精度和特异性至关重要 以及青少年药物成瘾弹性的预防干预计划。