COBRE Phase 2: Center for Neuroplasticity at the University of Puerto Rico

COBRE 第 2 阶段：波多黎各大学神经可塑性中心

基本信息

批准号：
10798588
负责人：
JOSE Antonio LASALDE-DOMINICCI
金额：
$ 25万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10798588
关键词：
AIDS dementia Alcohols Assistantship Behavior Control Biology Centers of Research Excellence Complex Crystallization Dementia Detergents Development Electrophysiology (science)Equipment Faculty Fellowship Goals Grant Growth Institution Interdisciplinary Study Ion Channel Ischemic Stroke Marketing Medical Mental disorders Microscope Molecular Natural Products Nature Neurologic Neuronal Plasticity Neuropeptides Phase Population Post-Traumatic Stress Disorders Postdoctoral Fellow Puerto Rico Research Research Personnel Schistosomiasis Science Scientist Services Source Students System Time United States National Aeronautics and Space Administration United States National Institutes of Health Universities Western Blotting addiction analog autism spectrum disorder design dietary supplements fast protein liquid chromatography graduate student improved instrument lipidomics neural neural circuit neuroadaptation neuroimaging neuroprotection recruit skills

项目摘要

Project Abstract The main goal of this application is to purchase four new pieces of equipment to enhance the UPR COBRE Center for Neuroplasticity (UPR-CCfN) and the Neuroimaging and Electrophysiological Facility (NIEF, https://www.nief-upr.com/) at the Molecular Science Research Center (MSRC, (http://cicim.upr.edu/). The UPR-CCfN is a collaborative effort between researchers from the Medical Sciences Campus and the Department of Biology at the Rio Piedras Campus. Its goal is to understand a wide range of neurological problems, including deciphering the neural circuits that control behavior, the origins of neural and mental health disorders such as autism, PTSD, dementia, elucidating the molecular basis for alcohol neuroadaptation, addiction, and neuroprotection. This supplemental application is the result of the collaborative efforts of 22 scientists to improve our COBRE UPR-CCfN. The increased demands on the variety of services and applications that must be provided by the NIEF have greatly increased based on its significant growth of users as well as the interdisciplinary nature of the science. We propose purchasing the following four new pieces of equipment: (1) Nikon Eclipse LV100N Polarized microscope, (2) Cytiva AKTA Purifier 100 FPLC System (3) LI-COR Odyssey Western Blot system and (4) QuantStudio 3 PRO-Real Time PRC system. After carefully evaluating various commercial sources on the market, we have determined these four instruments are ideal for the UPR-CCfN. These instruments will also impact a list of new investigators recently hired at the UPR-CCfN, as well as new grant projects that include biologically relevant studies such as HIV-associated dementia studies, lipidomic analysis of ion channels detergent-complexes to improve crystallization, schistosomiasis neuropeptide characterization, characterization of a neuroprotective nutritional supplement against ischemic stroke, and natural product analogs design. The proposed instruments will catalyze the multidisciplinary collaborations between researchers at the CCfN and other institutions within and outside of Puerto Rico. Another important aspect of the NIEF's development is the services the facility will provide to researchers being recruited shortly to pursue basic and biomedical-relevant projects at the UPR. Furthermore, the upgraded NIEF will optimize faculty, postdoctoral fellows, and graduate student expertise and skills so vital for competitive research. Finally, these instruments will greatly impact the development of the large student population currently supported by NIH, NASA, and NSF- sponsored fellowships or assistantships.

项目摘要该申请的主要目标是购买四台新设备以增强 UPR COBRE 神经可塑性中心 (UPR-CCfN) 和神经影像学和分子科学研究所的电生理设施（NIEF，https://www.nief-upr.com/）中心（MSRC，(http://cicim.upr.edu/)。UPR-CCfN 是以下机构之间的合作成果：来自里奥彼德拉斯医学科学校区和生物系的研究人员校园。其目标是了解广泛的神经系统问题，包括破译控制行为的神经回路、神经和精神健康疾病的起源，例如自闭症、创伤后应激障碍、痴呆、阐明酒精神经适应的分子基础、成瘾、和神经保护。该补充申请是 22 个组织共同努力的结果科学家们改进了我们的 COBRE UPR-CCfN。对各种服务的需求不断增加由于其重要性，NIEF必须提供的申请数量大大增加用户的增长以及科学的跨学科性质。我们建议购买以下四件新设备：(1) Nikon Eclipse LV100N 偏光显微镜，(2) Cytiva AKTA Purifier 100 FPLC 系统 (3) LI-COR Odyssey 蛋白质印迹系统和 (4) QuantStudio 3 PRO-实时 PRC 系统。经过仔细评估各种商业根据市场上的资源，我们确定这四种工具是 UPR-CCfN 的理想选择。这些工具还将影响 UPR-CCfN 最近聘用的新调查员名单，因为以及新的资助项目，其中包括生物学相关的研究，例如与艾滋病毒相关的研究痴呆症研究、离子通道去污剂复合物的脂质组学分析以改善结晶、血吸虫病神经肽表征、a 的表征对抗缺血性中风的神经保护性营养补充剂和天然产物类似物设计。拟议的文书将促进跨学科合作 CCfN 以及波多黎各境内外其他机构的研究人员。其他 NIEF 发展的一个重要方面是该设施将为研究人员提供的服务很快将被招募来开展普遍定期审议的基础和生物医学相关项目。此外，升级后的NIEF将优化教师、博士后研究员和研究生的专业知识，技能对于竞争性研究至关重要。最后，这些工具将极大地影响目前由 NIH、NASA 和 NSF 支持的大量学生群体的发展赞助的奖学金或助学金。