Deciphering the neural mechanisms of music processing in the developing brain: A multi-feature and multi-cultural comparison

解读发育中大脑中音乐处理的神经机制：多特征和多文化比较

• 批准号: 10798728
• 负责人: Yan Helen Yu
• 金额: $ 9.97万
• 依托单位: ST. JOHN'S UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-05 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798728
• 关键词: 10 year old; Acoustics; Address; Adolescent; Adult; African American; Age; American; Auditory; Behavior; Behavioral; Birth; Brain; Child; Childhood; Clinical; Cognition; Complex; Development; Event-Related Potentials; Goals; Language; Language Development; Language Development Disorders; Learning; Linguistics; Literature; Location; Mainstreaming; Music; Nervous System; Neurologic; Neurophysiology - biologic function; Periodicity; Physiology; Pitch Perception; Population; Process; Research; Resource Sharing; Rest; Slide; Speech; Speech Sound; Stress; Time; Training; age group; auditory processing; base; behavior measurement; behavioral outcome; behavioral response; bilingualism; developmental plasticity; early childhood; experience; improved; interest; lexical; nervous system disorder; neural; neural network; neurodevelopment; neuromechanism; neurophysiology; novel strategies; remediation; response; skills; speech processing

Project Summary Music training has long been used as a treatment to enhance neural function and behavioral outcomes in clinical populations. There is an extensive literature describing how music-training and tonal language learning alters the brain and behavior in healthy adult populations. One important unresolved issue is how music experience and language experience interact in the developing brain. Understanding how and to what extent music and language experience modulate cortical dynamics for brain functions (e.g., music and speech processing) will open a crucial door to treat a myriad of neurological conditions with an auditory or language base. The long-term overarching goal of this project is to uncover the causal relationship between brain networks and behavioral aspects of music sensitivity in the developing brain. This first project proposes to apply a combination of a music neurophysiological paradigm, a lexical tone neurophysiological paradigm and behavioral measures to uncover the complex interaction between music and lexical tone processing in the developing brain. The three specific aims are: 1) To determine the cortical maturational trajectories of auditory processing in terms of six main music features (rhythm, intensity, location, slide, pitch, and timbre) in 5-10 year old children. Event-related potential (ERP) responses will be compared across age groups. A multi-feature music oddball paradigm that includes six types of feature changes will be used. Significance: This aim is essential for examining brain developmental plasticity for the processing of different music features. 2) To determine whether early music training, tonal language, bilingual language experience and different English dialects modulate cortical sensitivity to the above-mentioned six main music features. The ERP responses will be compared across monolingual-bilingual, tonal-nontonal language, mainstream American English dialect – African American English dialect groups (monolingual English with mainstream American English dialect with and without music training, monolingual English with African American English dialect, bilingual Spanish- English and bilingual Mandarin-English). Significance: These comparisons are important because it will, for the first time, reveal the intricate relationship between dialectal experience, lexical tone development, bilingual development and brain development for music processing at the cortical level. 3) To determine whether, and to what extent, early music experience and language experience modulate cortical sensitivity to lexical tone processing. The ERP responses to lexical tone contrast will be compared across the above-mentioned groups of children. Significance: These comparisons are important because it will shed light on the relationship between early music training and the neural representations for speech processing.

项目摘要 音乐训练长期以来一直被用作增强神经功能和行为结果的治疗方法 在临床人群中。有广泛的文献描述了音乐训练和音调语言 学习会改变健康成人人群的大脑和行为。一个重要的未解决的问题是如何 音乐经验和语言经验在发展中的大脑中互动。 了解音乐和语言经验如何和在多大程度上调节皮质动力学 脑功能（例如音乐和语音处理）将打开一个关键的门来治疗无数的神经系统 带有听觉或语言基础的条件。该项目的长期总体目标是发现 大脑的大脑网络与发展大脑中音乐敏感性的行为方面之间的因果关系。 第一个实施音乐神经生理范式组合的项目提案，一种词汇音调 神经生理范式和行为措施，以发现音乐与 发育中的大脑中的词汇音调处理。 三个具体目的是：1）确定听觉处理的皮质成熟轨迹 在5-10岁 孩子们。与事件相关的电位（ERP）响应将在各个年龄组之间进行比较。多种音乐的音乐 ODBALL范式将使用包括六种类型的功能更改。意义：这个目标是必不可少的 用于检查大脑发育可塑性以处理不同的音乐功能。 2）确定 早期音乐培训，音调语言，双语语言经验和不同的英语方言 调节对上述六个主要音乐功能的皮质敏感性。 ERP的回应将是 在单语言，音调 - 文穿语言，主流美国英语方言中进行了比较 - 非裔美国人英语方言小组（单语英语与主流美国英语方言 没有音乐培训，单语英语和非裔美国人英语方言，双语西班牙语 - 英语和双语普通话 - 英语）。意义：这些比较很重要，因为它将 第一次揭示了方言体验，词汇开发，双语之间的复杂关系 在皮质层进行音乐加工的开发和大脑开发。 3）确定是否以及 早期音乐经验和语言经验在多大程度上调节皮质敏感性对词汇音调 加工。 ERP对词汇和词汇对比的响应将在上述组中进行比较 儿童。意义：这些比较很重要，因为它会阐明关系 在早期音乐训练和语音处理的神经表现之间。