Deciphering the neural mechanisms of music processing in the developing brain: A multi-feature and multi-cultural comparison

解读发育中大脑中音乐处理的神经机制：多特征和多文化比较

基本信息

批准号：
10798728
负责人：
Yan Helen Yu
金额：
$ 9.97万
依托单位：
ST. JOHN'S UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-05 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10798728
关键词：
10 year old Acoustics Address Adolescent Adult African American Age American Auditory Behavior Behavioral Birth Brain Child Childhood Clinical Cognition Complex Development Event-Related Potentials Goals Language Language Development Language Development Disorders Learning Linguistics Literature Location Mainstreaming Music Nervous System Neurologic Neurophysiology - biologic function Periodicity Physiology Pitch Perception Population Process Research Resource Sharing Rest Slide Speech Speech Sound Stress Time Training age group auditory processing base behavior measurement behavioral outcome behavioral response bilingualism developmental plasticity early childhood experience improved interest lexical nervous system disorder neural neural network neurodevelopment neuromechanism neurophysiology novel strategies remediation response skills speech processing

项目摘要

Project Summary Music training has long been used as a treatment to enhance neural function and behavioral outcomes in clinical populations. There is an extensive literature describing how music-training and tonal language learning alters the brain and behavior in healthy adult populations. One important unresolved issue is how music experience and language experience interact in the developing brain. Understanding how and to what extent music and language experience modulate cortical dynamics for brain functions (e.g., music and speech processing) will open a crucial door to treat a myriad of neurological conditions with an auditory or language base. The long-term overarching goal of this project is to uncover the causal relationship between brain networks and behavioral aspects of music sensitivity in the developing brain. This first project proposes to apply a combination of a music neurophysiological paradigm, a lexical tone neurophysiological paradigm and behavioral measures to uncover the complex interaction between music and lexical tone processing in the developing brain. The three specific aims are: 1) To determine the cortical maturational trajectories of auditory processing in terms of six main music features (rhythm, intensity, location, slide, pitch, and timbre) in 5-10 year old children. Event-related potential (ERP) responses will be compared across age groups. A multi-feature music oddball paradigm that includes six types of feature changes will be used. Significance: This aim is essential for examining brain developmental plasticity for the processing of different music features. 2) To determine whether early music training, tonal language, bilingual language experience and different English dialects modulate cortical sensitivity to the above-mentioned six main music features. The ERP responses will be compared across monolingual-bilingual, tonal-nontonal language, mainstream American English dialect – African American English dialect groups (monolingual English with mainstream American English dialect with and without music training, monolingual English with African American English dialect, bilingual Spanish- English and bilingual Mandarin-English). Significance: These comparisons are important because it will, for the first time, reveal the intricate relationship between dialectal experience, lexical tone development, bilingual development and brain development for music processing at the cortical level. 3) To determine whether, and to what extent, early music experience and language experience modulate cortical sensitivity to lexical tone processing. The ERP responses to lexical tone contrast will be compared across the above-mentioned groups of children. Significance: These comparisons are important because it will shed light on the relationship between early music training and the neural representations for speech processing.

项目概要音乐训练长期以来被用作增强神经功能和行为结果的治疗方法有大量文献描述了音乐训练和声调语言的作用。学习如何改变健康成年人的大脑和行为是一个尚未解决的重要问题。音乐体验和语言体验在发育中的大脑中相互作用。了解音乐和语言体验如何以及在多大程度上调节皮质动态大脑功能（例如音乐和语音处理）将为治疗各种神经系统疾病打开一扇重要的大门该项目的长期总体目标是揭示具有听觉或语言基础的条件。大脑网络与发育中大脑的音乐敏感性行为方面之间的因果关系。第一个项目建议结合音乐神经生理学范式、词汇音调神经生理学范式和行为测量揭示了音乐与音乐之间复杂的相互作用发育中的大脑中的词汇声调处理。三个具体目标是： 1）确定听觉处理的皮质成熟轨迹 5-10岁六大主要音乐特征（节奏、强度、位置、滑音、音高、音色）不同年龄组的儿童的事件相关电位（ERP）反应将进行比较。将使用包含六种类型的功能更改的奇怪范例。意义：这个目标至关重要。用于检查处理不同音乐特征的大脑发育可塑性。是否是早期音乐训练、声调语言、双语语言体验以及不同的英语方言调节皮质对上述六种主要音乐特征的敏感性 ERP 反应将是。单语-双语、声调-非声调语言、主流美式英语方言的比较 – 非裔美国英语方言群体（单语英语与主流美国英语方言没有音乐训练，单语英语与非裔美国人英语方言，双语西班牙语- 意义：这些比较很重要，因为它会首次揭示方言经验、词汇声调发展、双语之间错综复杂的关系皮质层音乐处理的发育和大脑发育 3) 确定是否，以及。早期音乐经验和语言经验在多大程度上调节皮层对词汇语气的敏感性将比较上述各组对词汇语气对比的 ERP 反应。意义：这些比较很重要，因为它将揭示这种关系。早期音乐训练和语音处理的神经表征之间的关系。