NIDCR Annual Reports - Veterinary Resources Core

NIDCR 年度报告 - 兽医资源核心

• 批准号: 10706920
• 负责人: Lauren Davidson
• 金额: $ 104.9万
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706920
• 关键词: Accreditation; Amendment; Animal Care and Use Committees; Animal Experimentation; Animals; Annual Reports; Caring; Committee Members; Consultations; Education; Gene Targeting; Health; Housing; Human Resources; IACUC; Intramural Research Program; Modification; Mus; National Institute of Dental and Craniofacial Research; Policies; Principal Investigator; Protocols documentation; Regulation; Research; Research Personnel; Resources; Review Committee; Rodent; Safety; Scientist; Services; Training; Transgenic Animals; Transgenic Mice; United States Department of Agriculture; United States National Institutes of Health; Writing; animal facility; animal resource; operation; programs; quality assurance; research study

The NIDCR Veterinary Resources program provides a dedicated animal facility that can accommodate 5344 mouse cages with a capacity up to house 26,720 mice to NIDCR investigators only. Additional housing for mice is provided in three shared or centralized animal facilities on the Bethesda NIH campus and can accommodate 1,589 additional mouse cages with a maximum capacity of 7945 mice. Only rodents are used by the intramural program of NIDCR. The NIDCR Animal Care and Use Committee (ACUC) reviewed and approved, or requested modifications for approval of 23 animal study proposals and approximately 64 protocol amendments. New personnel were added to approximately 44 approved protocols and 12 Annual Reviews of current animal study protocols were conducted by the ACUC. As of March 18, 2022, OLAW no longer requires Annual Reviews to be conducted by the IACUC. Training is required for all animal users, principal investigators, and ACUC members. NIDCR intramural scientists create and breed transgenic mice for experimental use in NIDCR operated and other NIH shared animal facilities. The NIDCR animal program is continually sharing these valuable animal resources and importing additional transgenic mice for specific research studies. The NIDCR Veterinary Resources Core maintains full AAALACi accreditation. Continual reviews of facility operations are conducted through day to day quality assurance and ACUC inspections in order to remain in good standing with all applicable regulations.

NIDCR兽医资源计划提供了一个专门的动物设施，该设施只能容纳5344个老鼠笼子，其容量只能容纳26,720鼠，仅向NIDCR调查人员提供。贝塞斯达NIH校园的三个共享或集中动物设施提供了小鼠的其他外壳，可容纳1,589个额外的鼠标笼，最大容量为7945只小鼠。 NIDCR的壁内程序仅使用啮齿动物。 NIDCR动物护理和使用委员会（ACUC）审查和批准，或要求修改23项动物研究建议和大约64项协议修正案。将新人员添加到大约44个批准的方案中，并通过ACUC对当前动物研究方案进行了12次年度审查。截至2022年3月18日，Olaw不再需要IACUC进行年度审查。 所有动物使用者，主要研究人员和ACUC成员都需要培训。 NIDCR壁内科学家创建并繁殖转基因小鼠，用于在NIDCR操作和其他NIH共享动物设施中实验性用途。 NIDCR动物计划正在不断共享这些有价值的动物资源，并将其他转基因小鼠进口用于特定研究。 NIDCR兽医资源核心保持了全部Aaalaci认证。对设施操作的持续审查是在日常的质量保证和ACUC检查中进行的，以保持良好的信誉。