NIDCR Annual Reports - Veterinary Resources Core

NIDCR 年度报告 - 兽医资源核心

• 批准号: 8929848
• 负责人: Lauren Davidson
• 金额: $ 65.03万
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929848
• 关键词: Accreditation; Amendment; Animal Care and Use Committees; Animal Experimentation; Animals; Annual Reports; Area; Breeding; Canis familiaris; Caring; Cavia; Committee Members; Consultations; Education; Felis catus; Fishes; Gene Targeting; Health; House mice; Housing; Human Resources; Intramural Research Program; Livestock; Modification; Mus; National Institute of Dental and Craniofacial Research; Policies; Principal Investigator; Protocols documentation; Rana; Rattus; Regulation; Research; Research Personnel; Resources; Safety; Scientist; Services; Site Visit; Time; Training; Transgenic Animals; Transgenic Mice; United States National Institutes of Health; Writing; Xenopus; animal facility; animal resource; nonhuman primate; programs; research study

In the last fiscal year, the NIDCR intramural animal research program used five guinea pigs,87,926 mice,370 rats,and 12 Xenopus frogs in research. The program provides a dedicated animal facility that can accommodate 5,760 mouse cages with a capacity up to 28,800 mice to NIDCR investigators only. The cage occupancy rate of that animal facility was about 98% of assigned space in August 2014. Additional mouse housing is provided in five other shared or centralized animal facilities on the Bethesda NIH campus and can accommodate 3,040 more mouse cages with a capacity of 15,200 mice. Housing for rats is provided by 224 rat cages with a capacity of about 650 rats in a shared facility. Currently, there are 8 Xenopus frogs that are housed in a separate aquatics holding area in another NIH campus animal facility. At this time no nonhuman primates, dogs, cats, farm animals, or fish are used by the intramural program of NIDCR. The NIDCR Animal Care and Use Committee reviewed and approved, or requested modifications for approval of 36 animal study proposals and 111 proposal amendments. New personnel were added to approximately 100 protocols and 62 Annual Reviews of current animal study protocols were conducted by the ACUC. Training is required for all animal users, principal investigators, and ACUC members. NIDCR intramural scientists create and breed transgenic mice for experimental use in NIDCR operated and other NIH shared animal facilities. The NIDCR animal program is continually sharing these valuable animal resources and importing additional transgenic mice for specific research studies. The NIDCR Veterinary Resources Core successfully completed the 2014 NIH AAALAC Site Visit in June 2014, maintaining full accreditation.

在上一个财政年度，NIDCR壁内动物研究计划使用了五只豚鼠，87,926只小鼠，370只大鼠和12只Xenopus蛙。该计划提供了一个专用的动物设施，该设施只能容纳5,760个小鼠笼，其容量只有多达28,800只小鼠，仅适用于NIDCR调查人员。该动物设施的笼子占用率约为2014年8月分配空间的98％。在贝塞斯达NIH校园的其他五个共享或集中的动物设施中提供了额外的小鼠外壳，可容纳3,040个小鼠笼子，其容量为15,200只小鼠。 224个老鼠笼子提供了大鼠的住房，共享设施的容量约为650只老鼠。目前，在另一家NIH校园动物设施中，有8种Xenopus蛙位于单独的水上饲养区中。此时，NIDCR的壁内计划使用了非人类灵长类动物，狗，猫，农场动物或鱼类。 NIDCR动物护理和使用委员会已审查和批准，或要求修改36个动物研究建议和111项提案修正案。将新人员添加到大约100条方案中，并通过ACUC对当前动物研究方案进行了62次年度审查。所有动物使用者，主要研究人员和ACUC成员都需要培训。 NIDCR壁内科学家创建并繁殖转基因小鼠，用于在NIDCR操作和其他NIH共享动物设施中实验性用途。 NIDCR动物计划正在不断共享这些有价值的动物资源，并将其他转基因小鼠进口用于特定研究。 NIDCR兽医资源核心在2014年6月成功完成了2014年NIH AAAALAC网站访问，并保持了全面认证。