NIAAA Repository/Screening Database Management and Research

NIAAA 存储库/筛选数据库管理和研究

• 批准号: 10710501
• 负责人: Melanie Schwandt
• 金额: $ 578.88万
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10710501
• 关键词: African American population; Aggressive behavior; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholic Hepatitis; Alcoholism; Alcohols; Annual Reports; Archives; Back; Behavior; Biochemical; Biological Markers; Body mass index; Brain; C-reactive protein; Cannabinoids; Cardiovascular system; Characteristics; Chronic stress; Clinic; Clinical; Clinical Research; Collaborations; Collection; Consumption; DNA Methylation; DRD2 gene; DSM-IV; Data; Data Analyses; Database Management Systems; Databases; Deposition; Diagnosis; Disease; Dopamine; Electrocardiogram; Eligibility Determination; Emotional; Enrollment; Ensure; Environment; Ethnic Origin; Etiology; Evaluation; Facial Expression; Factor Analysis; Food; Foundations; Future; GLP-I receptor; Gender; Genes; Genetic; Genetic Variation; Genetic study; Genomics; Genotype; Goals; Heterogeneity; Human; Human Genome; Immunoglobulins; Impulsivity; Indiana; Individual; Individual Differences; Inflammation; Inpatients; Institutes; Investigation; Iron; Laboratories; Laboratory Research; Life; Liver; Liver diseases; Major Depressive Disorder; Manuscripts; Measurement; Measures; Mental Depression; Metabolic; Micronutrients; Monitor; Mood Disorders; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Natural History; Neurobiology; Neurologic; Outcome; Pain; Participant; Patients; Pattern; Personality; Phenotype; Preparation; Protocols documentation; Psychiatric Diagnosis; Psychopathology; Public Health; Publications; Publishing; Quality of life; Race; Receptor Gene; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rest; Risk Factors; Role; SNP genotyping; Safety; Series; Severities; Signal Transduction; Sleep; Smoking; Standardization; Stearoyl-CoA Desaturase; Stress; Subgroup; Substance abuse problem; Suicide; Taste Buds; Therapeutic; Trauma; United States; United States National Institutes of Health; Universities; Update; Weight; Work; addiction; admixture mapping; adverse childhood events; alcohol effect; alcohol rehabilitation; alcohol response; alcohol risk; alcohol use disorder; anxiety symptoms; behavior measurement; behavioral health; binge drinking; biobehavior; childhood adversity; circadian; clinical care; comorbidity; craving; data sharing; depressive symptoms; drinking; drinking behavior; early life stress; epidemiology study; exome sequencing; falls; genetic variant; genomic data; ghrelin; human data; hypothalamic-pituitary-adrenal axis; imaging genetics; inpatient service; neurogenetics; neuroimaging; pediatric trauma; perceived stress; phenotypic data; prevent; problem drinker; programs; quality assurance; racial and ethnic disparities; relapse prediction; repository; resilience; resilience scale; reward anticipation; screening; sleep quality; stressor; substance use; timeline; trend; volunteer

As of this report, the NIAAA Repository/Natural History Database includes phenotype and/or genomic data on 3277 individuals. Phenotype data include psychiatric diagnoses, a variety of alcohol-related assessments and measures including lifetime and recent consumption and alcohol response phenotypes, personality and impulsivity measures, depression and anxiety symptoms, current and early life stress and trauma, aggression, suicidality, smoking, IQ, sleep quality, pain, and overall quality of life. Laboratory/biochemical measures are also available. Genomic data include 1) large-scale single nucleotide polymorphism (SNP) genotyping performed using Illumina arrays, 2) exome sequencing of a subset of subjects, both via a partnership between the Clinical Core Laboratory of the OCD, and the Laboratory of Neurogenetics (NIAAA), and 3) DNA methylation data for a subset of subjects via a partnership with the Laboratory of Neurogenetics. All NIAAA PIs and their research staff are encouraged to submit data requests in order to conduct research projects and analyses using the shared NIAAA Repository/Natural History Database. Projects are logged and the status is tracked from initial request to manuscript publication. In addition, Human and Genomic data are shared via BTRIS and other mechanisms, including collaboration with NIH-supported consortia (PGC Alcoholism, ENIGMA) to ensure data sharing. I. Projects (7) resulting in manuscripts published within the past year: Sleep and impulsivity in alcohol use disorder with comorbid mood disorder Inflammation, iron loading, and sleep quality in AUD Binge drinking behavior as a function of risk factors for alcohol use disorder Role of circadian and cannabinoid genes in Sleep and AUD Elevated stearoyl-coa desaturase 1 activity is associated with alcohol-associated liver disease An imaging genetics study of the prepro-ghrelin and glucagon-like peptide-1 receptor gene variants in alcohol use disorder An investigation into the role of metabolic biomarkers in the anticipation of reward in treatment seeking alcoholics II. Projects (3) resulting in manuscript submissions, revisions, or publications in press, within the past year: Association between FXYD2 and DRD2 genes and measures related to dopamine signaling in alcohol use disorder The role of C-Reactive protein in alcohol use disorder Role of current stress and perceived stress in alcohol-dependence severity and quality of life: an update to the study of childhood trauma in alcohol use disorder Quality of life among patients with alcohol use disorder and healthy controls: Examining the effects of genetics, childhood adversities, drinking histories, and lifetime suicidality III. Projects (6) with manuscripts in preparation: Latent profile analysis of impulsive and compulsive drinking Reporting of adverse childhood events as a function of race/ethnicity and gender and their influence on drinking behaviors Electrocardiogram and other cardiovascular indicators of at-risk alcohol drinking An investigation into the role of metabolic biomarkers in the anticipation of reward in treatment seeking alcoholics (second manuscript from this project) Immunoglobulin levels in alcohol use disorder and their association with comorbid major depressive disorder and chronic stress Association between dopaminergic genetic variation and IV alcohol consumption in the lab and in the field. IV. Ongoing projects (14) still in progress: Connor-Davidson Resilience Scale (CDRS): association with childhood trauma, alcohol-related outcomes and psychopathology. Data analyses are ongoing. Individual differences of Taste Receptor Genes and their association with alcohol-and food-related phenotypes and behaviors. Data analyses are ongoing. Comparison of resting state functional connectivity, alcohol consumption patterns, and CASE behavior as a function of CHRNA5 genotype. Data analyses are ongoing. Early life stress effects on emotional facial expression processing in individuals with alcohol use disorder. Data analyses are ongoing. Nicotinic alpha subunit effects on personality using confirmatory factor analysis. To be combined with the above project. Data analyses are ongoing. Neurobiological substrates of racial/ethnic disparity in alcohol use disorder: characterization of vulnerability/resilience via imaging, genetics, and biobehavioral information. Data analyses are ongoing. Characterization of drinking patterns in alcohol use disorder by Timeline Follow-Back variability analysis: association with craving, other substance use, psychopathology, and alcohol-related liver conditions. Data analyses are ongoing. An evaluation of binge drinking definitions and measurement: assessing the importance of consumption duration. Data analyses are ongoing. Analysis of weight trends and micronutrient stores in patients admitted to an inpatient alcohol rehabilitation program. Data analyses are ongoing. Association of amygdalar genes to negative emotionality in AUD and other addictive disorders. Data analyses are ongoing. Neurological predictors of relapse in alcohol use disorder. Data analyses are ongoing. Differences in hypothalamic-pituitary-adrenal axis responses to alcohol withdrawal-induced stress in black and white individuals with and without alcohol use disorder. Data analyses are ingoing. Interactions between the UPPS-P impulsivity facets and alcohol related outcomes. Data analyses are ongoing. The impact of trauma timing and load on brain-behavioral measures of Alcohol Use Disorder. Data analyses are ongoing. V. New projects (2) initiated within the past year: Differences between those with only AUD and those with AUD and depression with an emphasis on the ANA framework Association of early life and current stressors with alcohol use and BMI VI. Other Progress As a result of an established collaboration with Indiana University (Tatiana Foroud and Arpana Argawal), a manuscript was published including data from the NIAAA Repository/Screening Database, looking at admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. The collaboration with The Alcoholic Hepatitis Network project (AlcHepNet) is ongoing and data were shared with the group to be used in investigations of genetic variation and new treatments in alcoholic hepatitis.

截至本报告，NIAAA 存储库/自然历史数据库包含 3277 名个体的表型和/或基因组数据。表型数据包括精神病诊断、各种与酒精相关的评估和测量，包括一生和最近的饮酒和酒精反应表型、个性和冲动测量、抑郁和焦虑症状、当前和早期生活压力和创伤、攻击性、自杀倾向、吸烟、智商、睡眠质量、疼痛和整体生活质量。还提供实验室/生化测量。基因组数据包括 1) 使用 Illumina 阵列进行的大规模单核苷酸多态性 (SNP) 基因分型，2) 对一部分受试者进行外显子组测序，这两项数据均通过 OCD 临床核心实验室和神经遗传学实验室 (NIAAA) 之间的合作进行)，以及 3) 通过与神经遗传学实验室合作获得一部分受试者的 DNA 甲基化数据。 鼓励所有 NIAAA PI 及其研究人员提交数据请求，以便使用共享的 NIAAA 存储库/自然历史数据库进行研究项目和分析。记录项目并跟踪从最初请求到手稿出版的状态。此外，人类和基因组数据通过 BTRIS 和其他机制共享，包括与 NIH 支持的联盟（PGC 酒精中毒、ENIGMA）合作以确保数据共享。 一、近一年内发表论文的项目（7个）： 酒精使用障碍合并情绪障碍的睡眠和冲动 炎症、铁负荷和睡眠质量（澳元） 酗酒行为与酒精使用障碍危险因素的关系 昼夜节律和大麻素基因在睡眠和 AUD 中的作用 硬脂酰辅酶去饱和酶 1 活性升高与酒精相关性肝病有关 酒精使用障碍中前胃饥饿素原和胰高血糖素样肽 1 受体基因变异的成像遗传学研究 代谢生物标志物在酗酒者治疗奖励预期中的作用的调查 二.过去一年内导致稿件提交、修改或出版的项目 (3)： FXYD2 和 DRD2 基因之间的关联以及与酒精使用障碍中多巴胺信号传导相关的测量 C-反应蛋白在酒精使用障碍中的作用 当前压力和感知压力在酒精依赖严重程度和生活质量中的作用：酒精使用障碍儿童创伤研究的最新进展 酒精使用障碍患者和健康对照者的生活质量：检查遗传、童年逆境、饮酒史和终生自杀倾向的影响 三．正在准备稿件的项目（6）： 冲动性和强迫性饮酒的潜在特征分析 根据种族/民族和性别报告不良童年事件及其对饮酒行为的影响 有饮酒风险的心电图和其他心血管指标 代谢生物标志物在寻求酗酒者治疗奖励预期中的作用的调查（该项目的第二份手稿） 酒精使用障碍中的免疫球蛋白水平及其与共病重度抑郁症和慢性压力的关系 实验室和现场多巴胺能遗传变异与静脉注射酒精消耗之间的关联。 四．正在进行的项目 (14) 仍在进行中： 康纳戴维森复原力量表（CDRS）：与童年创伤、酒精相关结果和精神病理学的关联。数据分析正在进行中。 味觉感受器基因的个体差异及其与酒精和食物相关表型和行为的关联。数据分析正在进行中。 比较静息态功能连接、饮酒模式和 CASE 行为作为 CHRNA5 基因型的函数。数据分析正在进行中。 早期生活压力对酒精使用障碍患者情绪面部表情处理的影响。数据分析正在进行中。 使用验证性因素分析，烟碱α亚基对人格的影响。与上述项目结合。数据分析正在进行中。 酒精使用障碍中种族/民族差异的神经生物学基础：通过成像、遗传学和生物行为信息表征脆弱性/弹性。数据分析正在进行中。 通过时间线跟踪变异性分析来表征酒精使用障碍中的饮酒模式：与渴望、其他物质使用、精神病理学和酒精相关肝脏疾病的关联。数据分析正在进行中。 暴饮暴食定义和测量的评估：评估饮酒持续时间的重要性。数据分析正在进行中。 对接受住院酒精康复计划的患者的体重趋势和微量营养素储存进行分析。数据分析正在进行中。 杏仁核基因与 AUD 和其他成瘾性疾病中负面情绪的关联。数据分析正在进行中。 酒精使用障碍复发的神经学预测因素。数据分析正在进行中。 患有和不患有酒精使用障碍的黑人和白人的下丘脑-垂体-肾上腺轴对酒精戒断引起的应激反应的差异。数据分析正在进行中。 UPPS-P 冲动方面与酒精相关结果之间的相互作用。数据分析正在进行中。 创伤时间和负荷对酒精使用障碍大脑行为测量的影响。数据分析正在进行中。 五、近一年来新开工项目（2个）： 仅持有 AUD 的人与持有 AUD 和抑郁症的人之间的差异，重点是 ANA 框架 早期生活和当前压力源与饮酒和体重指数的关系 六．其他进展 作为与印第安纳大学（Tatiana Foroud 和 Arpana Argawal）建立合作的结果，发表了一份手稿，其中包括来自 NIAAA 存储库/筛选数据库的数据，研究了 DSM-IV 酒精依赖性的混合图、标准计数和自我乙醇对非裔美国人的影响的评级。 与酒精性肝炎网络项目 (AlcHepNet) 的合作正在进行中，并与该小组共享数据，用于研究酒精性肝炎的遗传变异和新疗法。