NIH-DOD Collaboration for Chemical Threats Affecting Cellular Respiration

NIH-DOD 合作应对影响细胞呼吸的化学威胁

• 批准号: 10709051
• 金额: $ 154.1万
• 依托单位: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709051
• 关键词: Acute; Address; Affect; Agreement; Biochemical; Cell Respiration; Chemicals; Chronic; Collaborations; Cyanides; Development; Educational workshop; Electrons; Evaluation; Exposure to; Fluoroacetates; Genomics; In Vitro; Metabolic; Microscopic; Modeling; Molecular; National Institute of Allergy and Infectious Disease; Phosphines; Physiological; Poison; Poisoning; Reporting; Research; Security; Sodium; Thallium; Therapeutic; Toxic effect; Toxicology; United States National Institutes of Health; base; chemical threat; efficacy testing; in vivo; medical countermeasure; model development; therapeutic candidate

The project under this IAA has been developed jointly by the NIAID/NIH CCRP and DoD/USAMRICD. Chemical Threats Affecting Cellular Respiration will be addressed under the scope of this IAA. This proposed Year 01 of 02 effort directly addresses the need to develop medical countermeasures against chemicals that have identified by the Department of Homeland Security (DHS) as threats to cellular respiration to include cyanide-based compounds. As such, the research purpose of this interagency agreement includes development of in vitro, in vivo, and/or ex vivo models of the acute and/or chronic long-term toxic effect of exposure to the chemical threats for the purpose of medical countermeasure development. Research under this IAA will focus on toxic chemicals specifically sodium fluoroacetate, cyanide, thallium, and phosphine. The rational development of the mature MCM product to be used as a therapeutic against chemicals affecting cellular respiration requires an understanding of the mechanisms of toxicity, a need which was specifically identified in the Report of the NIAID/NIH Expert Panel Workshop on Medical Countermeasures Against Cyanide (CN), January 25, 2005. This IAA may utilize state-of-the-art toxicological, biochemical, physiological, genomic and electron microscopic evaluation approaches to elucidate the molecular mechanism to support the efficacy testing.

该IAA下的项目由NIAID/NIH CCRP和DOD/USAMRICD共同开发。在此IAA的范围内将解决影响细胞呼吸的化学威胁。拟议的01年第1年的努力直接解决了针对国土安全部（DHS）确定的化学物质的医学对策的必要性，因为它对包括基于氰化物的化合物的蜂窝呼吸的威胁。因此，该机构间协议的研究目的包括在体内开发急性和/或慢性长期毒性的体外和/或离体模型，以实现医疗对策的发展，暴露于化学威胁的情况下。在该IAA下的研究将集中在有毒化学物质上，专门针对氟乙酸钠，氰化物，硫烷和磷酸钠。 The rational development of the mature MCM product to be used as a therapeutic against chemicals affecting cellular respiration requires an understanding of the mechanisms of toxicity, a need which was specifically identified in the Report of the NIAID/NIH Expert Panel Workshop on Medical Countermeasures Against Cyanide (CN), January 25, 2005. This IAA may utilize state-of-the-art toxicological, biochemical, physiological,基因组和电子显微镜评估方法阐明了分子机制以支持疗效测试。