Biospecimen & Clinical Database Core

生物样本

• 批准号: 10706319
• 负责人: Rafael Fonseca
• 金额: $ 46.35万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706319
• 关键词: Algorithms; Aliquot; Area; Arizona; Bioinformatics; Biological; Biological Specimen database; Biometry; Blood; Blood specimen; Bone Marrow; Bortezomib; COVID-19 pandemic; Cancer Center; Classification; Clinic; Clinical Data; Clinical Research; Clinical Trials; Collection; Data; Data Collection; Data Set; Databases; Dedications; Development; Disease; Early Diagnosis; Electronics; Florida; Funding; Geographic Locations; Goals; Grant; Individual; Information Systems; Infrastructure; Institution; Institutional Review Boards; K-Series Research Career Programs; Laboratories; Light-Chain Immunoglobulins; Link; Medicine; Metadata; Monoclonal gammopathy of uncertain significance; Multi-Institutional Clinical Trial; Multiple Myeloma; Natural Language Processing; Outcomes Research; Pathogenesis; Pathology; Patient Recruitments; Patients; Performance; Plasma Cells; Prevention; Process; Protocols documentation; Quality Control; Records; Regimen; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Safety; Sampling; Services; Specimen; System; Time; Tissue Banks; Translational Research; Tumor Tissue; Vesicular stomatitis Indiana virus; Virotherapy; Visit; Waldenstrom Macroglobulinemia; archive data; base; career; clinical database; clinical practice; clinical translation; data archive; data handling; data harmonization; design; high risk; innovation; migration; multiple omics; peripheral blood; primary amyloidosis of light chain type; programs; research and development; therapy outcome; translational study; treatment response; user-friendly

PROJECT SUMMARY/ABSTRACT This Biospecimens, Pathology, and Clinical Database Core will not only furnish essential services for the individual projects by managing patient data, safety, and samples, but it will provide a link between clinical data and research outcomes and interface with the Biostatistics and Bioinformatics Core to allow for formal interactions between existing datasets to develop relational networks. It will accomplish its goals by integrating with and building upon existing, successful infrastructure housed at the Mayo Clinic, making the Core an efficient, integral component of this SPORE. The significant patient referral base and clinical practice at the Mayo Clinic (>10,000 patient visits annually with multiple myeloma and related conditions) will allow substantial patient recruitment to the clinical trials and translational studies in this Mayo SPORE in multiple myeloma. The already extant 12,000+ bone marrow samples in our Biospecimens Core make SPORE and DRP projects possible. The on-going initiative of collecting data and research specimens from additional myeloma patients will feed into all SPORE projects and make Development Research and Career Development Award Programs possible. The Aims of the Core are: 1. to provide support for collection, transport, processing and storage of samples; 2. to supply the data system infrastructure to track all SPORE patients and samples; 3. to provide coordination and oversight of distribution of samples to SPORE investigators; and 4. to serve as a resource of expertise, collaborative support and service for full projects as well as Career Enhancement and Developmental Research Awardee research. This Core provides a mechanism of consistent and compatible data handling, thereby facilitating management of collected data and integration with data from existing Mayo resources. Areas of data support include database development, data form development and processing, quality control, data collection and entry, and data archiving. This Core is unique not only in its scope and potential, but also in that it will be built on existing (but currently unfunded) tissue banking facilities and processes at the Mayo Clinic in Rochester and in Arizona, guaranteeing successful performance. Finally, the Core will interface with the clinical research components of other SPORE grantees and cancer centers to facilitate multi-institutional clinical research arising out of national myeloma research efforts.

项目概要/摘要 该生物样本、病理学和临床数据库核心不仅将为 通过管理患者数据、安全性和样本来进行单个项目，但它将提供临床数据之间的链接 研究成果以及与生物统计学和生物信息学核心的接口，以允许正式 现有数据集之间的交互以开发关系网络。它将通过整合来实现其目标 并以梅奥诊所现有的成功基础设施为基础，使核心成为 该 SPORE 的高效、不可或缺的组成部分。 梅奥诊所拥有重要的患者转诊基础和临床实践（每年超过 10,000 名患者就诊） 多发性骨髓瘤和相关疾病）将允许大量患者招募到临床试验中， Mayo SPORE 在多发性骨髓瘤中的转化研究。现存 12,000 多个骨髓 我们的生物样本核心中的样本使 SPORE 和 DRP 项目成为可能。正在进行的倡议 从其他骨髓瘤患者那里收集数据和研究样本将输入到所有 SPORE 项目中， 使发展研究和职业发展奖励计划成为可能。核心的目标是： 1.为样品的采集、运输、处理和储存提供支持； 2. 提供数据系统基础设施来跟踪所有 SPORE 患者和样本； 3. 协调和监督向 SPORE 调查人员分发样本；和 4. 为整个项目以及职业提供专业知识、协作支持和服务的资源 增强和发展研究获奖者的研究。 该核心提供了一致、兼容的数据处理机制，从而方便管理 收集的数据并与现有梅奥资源的数据集成。数据支持领域包括 数据库开发、数据表单开发和处理、质量控制、数据收集和输入，以及 数据归档。该核心的独特之处不仅在于其范围和潜力，还在于它将建立在现有的基础上 （但目前没有资金）罗彻斯特和亚利桑那州梅奥诊所的组织库设施和流程， 保证演出的成功。最后，核心将与临床研究组件接口 其他 SPORE 受资助者和癌症中心，以促进国家资助的多机构临床研究 骨髓瘤研究工作。