Science and Technology Resources

科技资源

• 批准号: 10703149
• 负责人: David Goldstein
• 金额: $ 420.26万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10703149
• 关键词: Agreement; Area; Bioinformatics; Biological; Biomedical Research; Biometry; Biotechnology; CCR; Clinical Research; Communities; Computer software; Contracts; Cost Savings; Data; Databases; Dissection; Educational workshop; Event; Funding; Funding Mechanisms; Gene Expression Profiling; Genomics; Image; Individual; Investigation; Journals; Laboratories; Licensing; Mammalian Cell; Mediation; Microarray Analysis; Pathway interactions; Principal Investigator; Private Sector; Protein Analysis; Proteins; Proteomics; Publications; Reporting; Research; Research Personnel; Resources; Science; Scientist; Services; Signal Transduction; Statistical Data Interpretation; Technology; Technology Transfer; Training; Transfer Agreement; Translational Research; United States National Institutes of Health; Work; assay development; base; bioinformatics tool; biomarker development; clinical application; cost; experimental study; high throughput analysis; high throughput technology; metabolomics; nanoscale; new technology; next generation sequencing; programs; protein expression; response; single cell analysis; therapeutic target; transcriptomics

The OSTR is supporting a number of protein characterization analyses in mammalian cells for CCR investigators through the Laboratory of Protein Characterization at the Frederick National Lab (FNL). The OSTR continues to evaluate all commercially available platforms for protein and gene expression profiling and other high throughput technologies. To make the latest advances easily accessible to CCR researchers, the OSTR has established a number of arrangements with companies providing genomic and metabolomic profiling technologies and services. These agreements have led to far lower cost and an efficient and easy way for CCR investigators to access these technologies. A subsidy program has been established providing subsidies to support CCR investigator access to advanced genomic, proteomic, metabolomic, and bioinformatic technologies. This funding mechanism has helped to extend the limited research dollars available to CCR laboratories and has permitted our researchers to conduct experiments that might otherwise be cost prohibitive. Many of the funded projects have led to important publications in top-tier journals. Most recently, the OSTR has been involved in CCR's efforts to access the next generation sequencing technologies, including the setting up of a new single cell analysis facility now located building 41, which is available to any CCR investigator. In response to CCR's rapidly growing need to manage and analyze large sets of genomic and proteomic data, the OSTR has developed several partnerships with bioinformatics companies. At significant cost savings to NCI, OSTR negotiated a variety of license agreements on behalf of all NCI researchers for universal access to sophisticated tools for bioinformatic and statistical analysis of microarray experiments, proteomic profiling studies, and genomic analysis including next-generation sequencing data. In addition, the OSTR has made a number of software applications for the investigation of pathways and biological association networks available to all of NCI. The OSTR continues to assess CCR's requirements in the area of bioinformatics and biostatistics. We continue to work with Leidos Biomedical Research (LBR) to create a CCR dedicated Bioinformatics Program to provide support to CCR investigators. Support for analysis of high throughput genomic and proteomic data is being made available through this new program, which is located on the Bethesda campus. Most recently, the OSTR has taken on the management of the NanoScale Proteomics section of the Collaborative Protein Technology Resource. This Core is an open to all CCR investigators and dedicated to developing and implementing cutting-edge protein-based technologies to facilitate discovery, translational and clinical research in CCR/NCI/NIH. This Core offers expertise and provides state-of-the-art technologies to accommodate the demands of CCR/NCI/NIH investigators for: Rapid and precise protein analysis; Comprehensive and quantitative cell signaling event dissection; Nanoscale quantitative proteomics assessment; Biomarker development and therapeutic target identification; and, Clinical applicable assay development and applications. Most recently, the CPTR is offering spatial proteomics and transcriptomics to the CCR community. This Core is reported separately.

OSTR通过Frederick National Lab（FNL）的蛋白质表征实验室（FNL），支持哺乳动物细胞中CCR研究人员的许多蛋白质表征分析。 OSTR继续评估所有市售的平台，用于蛋白质和基因表达分析和其他高通量技术。为了使CCR研究人员容易获得最新进展，OSTR已与提供基因组和代谢组分技术和服务的公司建立了许多安排。这些协议导致了CCR调查人员访问这些技术的高效，简便的方法。已经建立了一项补贴计划，提供补贴，以支持CCR研究者访问高级基因组，蛋白质组学，代谢组和生物信息学技术。这种资金机制有助于扩大CCR实验室可用的有限的研究资金，并允许我们的研究人员进行实验，否则可能是成本高昂的。许多资助的项目导致了顶级期刊的重要出版物。最近，OSTR参与了CCR访问下一代测序技术的努力，包括建立了现在位于41大楼的新单细胞分析设施，任何CCR研究人员都可以使用。为了响应CCR管理和分析大量基因组和蛋白质组学数据的迅速增长的需求，OSTR与生物信息学公司建立了多种合作伙伴关系。 OSTR以大幅节省的成本节省，代表所有NCI研究人员协商了各种许可协议，以通用用于微阵列实验的生物信息和统计分析的复杂工具，蛋白质组学分析研究以及基因组分析，包括下一代测序数据。此外，OSTR为所有NCI提供的途径和生物协会网络的调查提供了许多软件应用程序。 OSTR继续评估CCR在生物信息学和生物统计学领域的要求。我们继续与Leidos生物医学研究（LBR）合作，创建一个专门的生物信息学计划，为CCR研究人员提供支持。通过位于贝塞斯达校园的这个新程序提供了对高通量基因组和蛋白质组学数据进行分析的支持。最近，OSTR采用了协作蛋白技术资源的纳米级蛋白质组学部分的管理。该核心向所有CCR研究人员开放，并致力于开发和实施基于尖端的蛋白质技术，以促进CCR/NCI/NIH的发现，转化和临床研究。该核心提供专业知识，并提供最先进的技术，以适应CCR/NCI/NIH研究人员的需求：快速，精确的蛋白质分析；综合和定量的细胞信号传导事件解剖；纳米级定量蛋白质组学评估；生物标志物发育和治疗靶标识别；以及临床适用的测定开发和应用。最近，CPTR向CCR社区提供了空间蛋白质组学和转录组学。该核心分别报告。