Hypertension in Pregnancy and Future Cardiovascular Disease

妊娠期高血压和未来的心血管疾病

基本信息

批准号：
8927520
负责人：
VIRGINIA M MILLER
金额：
$ 23.79万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8927520
关键词：
Address Affect Age Biological Blood Platelets Brain Cardiovascular Diseases Cardiovascular system Caring Case-Control Studies Chronic Clinical Cognition Cognitive Cohort Studies County Data Dementia Diagnosis Diagnostic Disease Disease Outcome Educational workshop Epidemiologic Studies Epidemiology Female Frequencies Future Guidelines Health Heart Diseases Heart failure Hormone use Hypertension Impaired cognition Incidence Life Menopause Morbidity - disease rate Mothers National Heart, Lung, and Blood Institute Outcome Pathogenesis Patient Self-Report Patients Postpartum Period Pre-Eclampsia Pregnancy Prevention Proteinuria Publishing Recording of previous events Records Recruitment Activity Reporting Research Residual state Risk Risk Factors Sampling Series Sex Characteristics Stroke Subgroup System Testing Time Treatment Efficacy Variant Vascular Diseases Woman base cardiovascular risk factor cerebrovascular cognitive function cognitive testing endothelial dysfunction fetal male men modifiable risk mortality neuroimaging normotensive outcome forecast population based pregnancy disorder pregnancy hypertension sex treatment strategy

项目摘要

Cardiovascular epidemiologic research historically has focused on men, because male sex is one of the major risk factors for CVD. Consequently, numerous diagnostic and treatment strategies for CVD in women have been extrapolated from results of studies conducted in men, and sex-specific factors largely have been ignored. It became apparent in the 1980s that the decrease in cardiovascular mortality in men was not accompanied by a similar decrease in women. One of the reasons for this difference might be sex-based disparities in cardiovascular care; women have been both under evaluated for CVD and under treated for modifiable risk factors for CVD. In addition, female-specific conditions, such as hypertensive disorders of pregnancy, menopause, and hormone use, might affect the onset of CVD, its clinical course, the efficacy of therapy, and, ultimately, prognosis. This proposal responds to RFA-OD-11-003 by identifying complications of hypertensive pregnancy disorders as a major biological sex difference that may influence the future cardiovascular and cognitive health of the affected women. Results of the proposed research may open new venues for the prevention, diagnosis, and treatment of CVD and cognitive impairment in women.

历史上，心血管流行病学研究主要集中在男性，因为男性是主要的流行病学研究对象之一。 CVD 的危险因素。因此，针对女性 CVD 的多种诊断和治疗策略已经出现是根据对男性进行的研究结果推断出来的，并且性别特异性因素在很大程度上被忽略了。 20 世纪 80 年代，男性心血管死亡率并没有随之下降，这一点变得很明显。女性也有类似的下降。造成这种差异的原因之一可能是基于性别的差异心血管护理；女性的 CVD 评估和可改变的治疗均不足 CVD 的危险因素。此外，女性特有的病症，例如妊娠期高血压疾病，更年期和激素的使用可能会影响 CVD 的发病、临床病程、治疗效果，并且，最终，预测。该提案通过识别妊娠期高血压疾病的并发症来响应 RFA-OD-11-003 作为一个主要的生物性别差异，可能会影响未来的心血管和认知健康受影响的妇女。拟议研究的结果可能会为预防、诊断和治疗开辟新的场所。治疗女性心血管疾病和认知障碍。