Pathology and Biobanking

病理学和生物样本库

• 批准号: 10704515
• 负责人: George Miles
• 金额: $ 46.85万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-19 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704515
• 关键词: Biological Assay; Biological Specimen Banks; Breast Cancer Patient; Clinical; Development; Histopathology; Molecular; Pathology; Testing; Translational Research; Validation; biobank; biomarker discovery; biomarker validation; improved; malignant breast neoplasm; novel

Abstract The Pathology and Biobanking Core (PBC) has supported the efforts of the Baylor College of Medicine Breast SPORE for 26 years, offering comprehensive pathology services to SPORE investigators and others. All projects in this SPORE application propose the use of human biospecimens in assay development and for retrospective and/or prospective clinical trials, and this shared resource core is structured to meet the demands for high-quality, centralized banking and distribution of tissue specimens within this context. We have expertise and dedicated personnel for all routine histological studies, immunohistochemistry, immunofluorescence, tissue microarray preparation, and macro/micro-dissection techniques. Additionally, the Core supports advanced microscopy and digital imaging capability. All projects will also benefit from our recent expansion of state-of-the art molecular diagnostic platforms and high-complexity assay development, including quantitative PCR, microfluidics-based digital droplet PCR (ddPCR), next generation sequencing (NGS). The Core will provide the following services to projects and integration with other cores in this proposal: 1) a centralized resource to acquire, store, and utilize human biospecimens for cancer research; 2) To coordinate and manage the pathology activities of the SPORE, and ensure that Project Investigators have ready access to specialized pathology expertise and interpretation; and 3) to design and validate biomarker-based tests (genomic and/or proteomic) that support all project stages, including clinically-validated and reported assays for SPOREbased clinical trials. The SPORE benefits from integrated interactions between components, and this Core will work closely with other cores, particularly the Informatics and Statistics Core (ISC) for project design and correlative analyses. Further we will collaborate with the ISC to assist with selection and implementation of biospecimen repository, tracking and management software that spans all SPORE components. We will work with the Administration and Advocacy Core in management of laboratory resources and assist Career Development trainees with education in assay development and experimental analysis. The Core will assist proposed and funded Pilot Studies with exploratory assay design and technical validation support. The Pathology and Biobanking Core Laboratory is seeking both CLIA- and CAP-certification to meet Precision Medicine initiatives of this SPORE at Baylor College of Medicine.

抽象的 病理学和生物样本库核心 (PBC) 支持贝勒医学院的努力 乳腺 SPORE 26 年，为 SPORE 研究人员和其他人员提供全面的病理学服务。全部 此 SPORE 应用程序中的项目建议在检测开发中使用人类生物样本 回顾性和/或前瞻性临床试验，这个共享资源核心的结构是为了满足需求 在此背景下实现组织样本的高质量、集中存储和分发。我们有专业知识 以及所有常规组织学研究、免疫组织化学、免疫荧光、组织学研究的专职人员 微阵列制备和宏观/微观解剖技术。此外，该核心还支持高级 显微镜和数字成像能力。所有项目也将受益于我们最近的最新扩展 先进的分子诊断平台和高复杂性检测开发，包括定量 PCR、 基于微流控的数字液滴 PCR (ddPCR)、下一代测序 (NGS)。 该核心将为项目提供以下服务并与本提案中的其他核心集成： 1) 获取、存储和利用人类生物样本进行癌症研究的集中资源； 2）协调 并管理 SPORE 的病理活动，并确保项目研究人员可以随时访问 专门的病理学专业知识和解释； 3) 设计和验证基于生物标记的测试（基因组 和/或蛋白质组学），支持所有项目阶段，包括基于 SPORE 的临床试验的临床验证和报告的测定。 SPORE 受益于组件之间的集成交互，并且该核心将紧密合作 与其他核心，特别是用于项目设计和相关分析的信息学和统计核心（ISC）。 此外，我们将与 ISC 合作，协助选择和实施生物样本库， 涵盖所有 SPORE 组件的跟踪和管理软件。我们将与政府合作 和倡导核心管理实验室资源，并协助职业发展学员 测定开发和实验分析方面的教育。核心将协助提议和资助的试点 具有探索性测定设计和技术验证支持的研究。病理学和生物样本库核心 实验室正在寻求 CLIA 和 CAP 认证，以满足该 SPORE 的精准医学计划 贝勒医学院。