Oklahoma Rheumatic Disease Research Cores Center

俄克拉荷马州风湿病研究核心中心

基本信息

批准号：
10704387
负责人：
JUDITH A JAMES
金额：
$ 85.25万
依托单位：
OKLAHOMA MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-07 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10704387
关键词：
Address Aliquot American Applications Grants Basic Science Biological Markers Caring Cells Certification Clinical Clinical Data Clinical Management Clinical Research Clinical Trials Clinical Trials Design Cohort Studies Collaborations Collection Communication Complex Cytometry Data Development Diagnosis Disease Distant Educational workshop Electronics Enrollment Evaluation Fostering Funding Genetic Goals Health Heterogeneity Human Human Resources Immunologic Monitoring Immunologics Individual Information Systems Infrastructure Institution Institutional Review Boards Investigation Investments Leadership Lupus Manuscripts Mediator Mentors Mission Molecular Monitor Morbidity - disease rate National Institute of Allergy and Infectious Disease National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Oklahoma Participant Pathogenesis Pathologic Pathologist Patient Selection Patient-Focused Outcomes Patients Phenotype Pilot Projects Precision therapeutics Preparation Prevention Procedures Process Prognosis Program Development Proteomics Protocols documentation Research Research Design Research Infrastructure Research Personnel Resources Rheumatism Sampling Scholars Program Science Scientist Seasons Selection for Treatments Services Symptoms Technology Testing Training Training Programs Underrepresented Populations Underserved Population Visit Work Writing assay development base biobank career career development clinical phenotype cohort college data warehouse disease classification empowerment experience forging high dimensionality improved innovation inter-institutional investigator-initiated trial molecular phenotype mortality multidimensional data multidisciplinary multiple omics next generation novel outreach patient subsets phenotypic data precision medicine programs recruit sample collection skills success systems research technology platform transcriptomics web-enabled young woman

项目摘要

Oklahoma Rheumatic Disease Research Cores Center: Overall The mission of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) is to support and optimize interactions between basic, clinical, and analytical scientists focused on the pathogenesis, prediction, prevention, and precision therapeutic selection for rheumatic diseases. Towards this aim, the ORDRCC integrates 26 established center investigators, 22 junior center investigators (12 within and 10 outside Oklahoma), and 12 potential scholars to develop early-stage investigators with outstanding promise in rheumatic disease research. The ORDRCC infrastructure, collections, Cores and Enrichment Program have helped successfully launch the independent careers of 33 former New Investigators. In addition, our CAP- certified Biorepository within the Clinical Characterization and Biorepository Core (CCBC) provides access to well-phenotyped cross-sectional and longitudinal rheumatic disease sample collections. The ORDRCC- supported collections and biorepository infrastructure are critical resources for many established rheumatic disease investigators from within the ORDRCC and through inter-institutional rheumatic disease collaborations and clinical trials. In the past 4 years, the CCBC personnel have assisted with 151 IRB study protocols, recruitment of 1,282 participants, performed 2,648 cohort study visits and collected/processed 66,068 new sample aliquots, as well as fulfilled 571 samples or data requests. The CCBC will continue to expand these collections while providing clinical research units for study recruitment and regulatory assistance. Furthermore, the CCBC will develop an Innovation Hub to pilot novel clinical research approaches and a clinical trialist development program. The Human Phenotyping Core (HPC) provides experienced technical personal, standard operating procedures, training, and analytical expertise to empower ORDRCC investigators to use cutting-edge technologies, including high-dimensional cytometry, single-cell multi-omics, transcriptomics, spatial multi-omics, and high-throughput testing of soluble mediators. Together, the CCBC and HPC transform rheumatic disease investigation and clinical trials by integrating clinical and molecular information to identify molecularly homogeneous subsets of subjects for use in innovative study design. The Administrative Core serves as the central management and communication hub for the ORDRCC and co-ordinates a multi- disciplinary Enrichment Program, including a new rheumatic disease pipeline development program for underrepresented groups, a mentoring program, a new Science Writing Success Center to assist investigators with developing robust manuscripts and competitive grant applications, and Expanding Rheumatic Disease Research Colloquiums to increase outreach and forge interactions between ORDRCC scientists and other NIAMS Centers. Together, the ORDRCC facilitates and expands collaborative rheumatic disease research by providing career development, cutting-edge technologies, well-phenotyped clinical data, and fostering collaborations to improve patients’ lives.

俄克拉荷马州风湿病研究核心中心：总体俄克拉荷马州风湿病研究中心（ORDRCC）的使命是支持和优化基本，临床和分析科学家之间的相互作用，专注于发病机理，预测，预防和用于风湿病的精确治疗选择。朝着这个目标，ORDRCC 综合26个成立中心调查员，22名初级中心调查员（外部有12名，有12个俄克拉荷马州），还有12名潜在的学者来培养早期阶段的调查员，并在风湿病研究。 ORDRCC基础架构，收集，核心和丰富计划已有帮助成功启动了33位前新调查员的独立职业。此外，我们的上限临床表征和生物座核（CCBC）中认证的生物座席提供了访问良好的横断面和纵向风湿病样品收集。 ORDRCC- 支持的收藏和生物座位基础设施是许多既定风湿性的关键资源来自ORDRCC内部以及通过机构间风湿病合作的疾病研究者和临床试验。在过去的四年中，CCBC人员协助了151种IRB研究方案，招募1,282名参与者，进行了2,648个队列研究访问并收集/处理66,068 样本等分试样，并完成了571个样本或数据请求。 CCBC将继续扩展这些收集在提供研究招聘和监管援助的临床研究单位的同时。此外， CCBC将开发一个创新枢纽，以实行新颖的临床研究方法和临床试验师发展计划。人类表型核心（HPC）提供了经验丰富的技术个人，标准操作程序，培训和分析专业知识，以增强ORDRCC调查人员的能力尖端技术，包括高维细胞仪，单细胞多摩斯，转录组学，空间多矩和实心介体的高通量测试。 CCBC和HPC转换在一起风湿病研究和临床试验通过整合临床和分子信息来识别用于创新研究设计的受试者的分子均匀子集。行政核心是ORDRCC的中央管理和通信中心，并协调一个多纪律丰富计划，包括针对新的风湿病管道开发计划代表性不足的小组，一个心理计划，一个新的科学写作成功中心，旨在协助调查人员通过发展强大的手稿和竞争性赠款应用，并扩大风湿病研究座谈会以增加ORDRCC科学家与其他人之间的外展和锻造相互作用尼亚姆斯中心。 ORDRCC的收藏夹共同扩展了合作性风湿病研究提供职业发展，尖端技术，良好的临床数据和培养改善患者生活的合作。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications for Pathogenic Mechanism and Drug Targeting.

DOI：
10.3390/genes12121898
发表时间：
2021-11-26
期刊：
Genes
影响因子：
3.5
作者：
Marion MC;Ramos PS;Bachali P;Labonte AC;Zimmerman KD;Ainsworth HC;Heuer SE;Robl RD;Catalina MD;Kelly JA;Howard TD;Lipsky PE;Grammer AC;Langefeld CD
通讯作者：
Langefeld CD