Core A: Administrative Core

核心A：行政核心

• 批准号: 10689276
• 负责人: Rong Fan
• 金额: $ 24.54万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689276
• 关键词: Acceleration; Aging; Agreement; Area; Atlases; Biological Assay; Biomedical Engineering; Biomedical Research; Bone Marrow; Calendar; Cell Aging; Cells; Chronic; Chronic Disease; Clinical; Collaborations; Communication; Communities; Complex; Confounding Factors (Epidemiology); Data; Decision Making; Development; Disease; Educational workshop; Ensure; Environment; Evaluation; Event; Generations; Grant; Group Meetings; Hematology; Heterogeneity; Histopathology; Human; Immune; Immunobiology; Immunology; Impairment; Inflammation; Injury; Institution; Intellectual Property; Interest Group; Joints; Journals; Laboratories; Leadership; Malignant - descriptor; Maps; Metadata; Mission; Modality; Modeling; Monitor; Motivation; Online Systems; Organ; Physicians; Physiological; Physiological Processes; Physiology; Policies; Predisposition; Procedures; Production; Proliferating; Protocols documentation; Publications; Research; Research Activity; Research Personnel; Resource Sharing; Role; Schedule; Scientist; Site; Standardization; Structure; System; Technology; Testing; Therapeutic Intervention; Thymus Gland; Tissues; Tonsil; United States National Institutes of Health; Update; Work; biomarker development; data access; data dissemination; data format; data integration; data sharing; experience; experimental study; genome-wide; human tissue; improved; lymph nodes; lymphoid organ; mange; meetings; multidisciplinary; neoplastic cell; operation; organizational structure; outreach; prevent; programs; sample collection; senescence; synergism; targeted treatment; tissue mapping; working group; wound healing

PROJECT SUMMARY – Core A (Administrative Core) Yale TMC aims to map cellular senescence in primary (bone marrow and thymus) and secondary (tonsil and lymph node) lymphoid organs, which requires assembling a highly multidisciplinary team with diverse expertise to characterize and understand cellular senescence and associated environments in human tissues. The Administrative Core is led by Drs. Fan and Halene, whose have a long-standing record of active collaboration, extensive experience in NIH consortium activities, and the management of large team projects. A program manager will coordinate all administrative activities within Yale TMC and the communications with NIH SenNet program staff. Specifically, the Administrative Core will fulfill the following key functions: (1) establish a leadership plan and the operation structure to supervise and manage all research activities, set up a decision- making procedure for the TMC’s governance, establish supervisory mechanisms to ensure effective internal management of ongoing research and participation in SenNet activities; (2) establish the TMC coordination plan including communications and collaborations between the Cores within Yale TMC, define and monitor specific responsibilities of each Core, manage the pilot grant projects, evaluate progress and milestones, and develop strategies to minimize confounding factors in data generation and sharing; (3) develop a SenNet consortium coordination plan including participation in the steering committee to improve and implement operation protocols, joining or creating new interest groups such as “spatial omics” and “immune cell senescence”, make commitment to work with CODCC and other TMCs for protocol and data integration and sharing, and mange trans-network collaborations. We will adhere to Network-wide policies and procedures established by the NIH and the SenNet Steering Committee, including data access, publication, and intellectual property policies. We will also abide by, Memoranda of Understanding and other sharing agreements potentially needed for data and biospecimen sharing within the Network and other related programs. The Administrative Core will develop outreach activities to enhance data dissemination and utilization by the large research community to improve our understanding of cellular senescence, heterogeneity and associated environments in development, aging, and disease.

项目摘要 - 核心A（行政核心） 耶鲁TMC旨在绘制原发性（骨髓和胸腺）和次级（扁桃体和 淋巴结）淋巴器官，它需要组装具有潜水员专业知识的高度多学科团队 表征和理解人体组织中的细胞感应和相关环境。 行政核心由Drs领导。范和哈利恩（Halene），他们的积极合作有着长期的记录 NIH联盟活动和大型团队项目的管理经验丰富。一个程序 经理将协调耶鲁TMC内的所有行政活动以及与NIH Sennet的通信 计划人员。具体而言，管理核心将履行以下关键功能：（1）建立一个 领导计划和运营结构，以监督和管理所有研究活动，制定决定 - 为TMC的治理制定程序，建立监督机制以确保有效的内部 正在进行的研究和参与SENNET活动； （2）建立TMC协调 计划包括耶鲁TMC内核心之间的通信和合作，定义和监视 每个核心的具体责任，管理飞行员赠款项目，评估进度和里程碑，以及 制定策略，以最大程度地减少数据生成和共享中的混杂因素； （3）开发一个sennet 财团协调计划，包括参加指导委员会改善和实施的指导委员会 操作协议，加入或创建新的兴趣组，例如“空间幻象”和“免疫细胞” 感应”，将承诺与CODCC和其他TMC合作进行协议和数据集成以及 共享和Mange Trans-Network合作。我们将遵守网络范围的政策和程序 由NIH和Sennet指导委员会成立，包括数据访问，出版和知识分子 财产政策。我们还将遵守理解和其他共享协议的备忘录 网络和其他相关程序中的数据和生物测量共享可能需要。 行政核心将开发外展活动，以增强大型数据传播和利用 研究社区，以提高我们对细胞感应，异质性和相关性的理解 发展，衰老和疾病的环境。