Biospecimen Core

生物样本核心

基本信息

批准号：
10689778
负责人：
Carolyn Glass
金额：
$ 68.08万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10689778
关键词：
Academic Medical Centers Accreditation Age Ambulatory Care Facilities Atlases Autopsy Biological Biological Assay Biological Markers Biopsy Blood specimen Board Certification Bronchoscopy Cardiac Surgery procedures Cell Aging Cell Proliferation Cells Childhood Clinic Clinical Clinical Data Clinical Trials Collaborations Collection Colon Communities Consent Consent Forms Country Coupled Diagnosis Elderly Endoscopy Enrollment Ensure Epidemiology Evaluation Exposure to Faculty Fresh Tissue Funding Gastroenterology Goals Health Heart Heart Transplantation Heterogeneity Home Hospitals Individual Infant Informatics Institution International Intervention Investigation Laboratories Language Liquid substance Longevity Lung Lung Transplantation Maps Measures Modification Molecular Muscle Normal tissue morphology Operative Surgical Procedures Organ Organ Donor Organ Transplantation Participant Pathologic Pathologist Pathology Perinatal Phase Population Practice Guidelines Predisposition Procedures Process Protocols documentation Pulmonology Quality Control Race Regulation Research Research Personnel Research Support Resource Sharing Sampling Schedule Secure Services Skin Socioeconomic Status Somatic Mutation Source Specimen Swab Tissue Banks Tissue Procurements Tissues Training United States Work age group biobank body system clinically relevant cohort data management data repository data sharing demographics environmental stressor fetal gender diversity human tissue interest middle age participant enrollment peripheral blood postmitotic programs prospective quality assurance real time monitoring recruit saliva sample scale up senescence standard of care stem cells stool sample tissue mapping tissue resource transplant centers

项目摘要

ABSTRACT – Biospecimen Core The Biospecimen Core is essential for the acquisition of all biospecimens, verification of “normal healthy tissue” diagnosis, processing and allocation of all tissue and associated biofluids/non-tissue specimens required for SCENT. Integration of multiple, well-established Duke institutions with highly specialized collaborative capabilities is a unique strength of this Core. We are a nationally recognized biorepository and one of the highest organ transplantations centers in the country. Biobanking activities occur in parallel with standard of care biopsies, scheduled surgical procedures, autopsies and organ donor procurements. The objective of this Core is to provide biospecimen services with exceptional quality control measures to enable tissue mapping of cellular senescence biomarkers in normal healthy tissues across the lifespan (fetal/perinatal to elderly). This Core will be led by a team with expertise in autopsy, organ donor and surgical tissue procurement. To accomplish our goals, we will work to 1) efficiently identify, procure and verify diagnoses of high-quality normal healthy tissue and concurrent biofluids/non-tissue specimens based on stringent criteria, 2) process high-quality normal healthy tissues for correlative analyses and 3) ensure quality assurance and quality controls for sample management, specimen tracking and biobanking informatics management for optimal banked tissue sharing for all SenNet funded institutions. Our long-term goal is to constantly evolve to meet the needs of our investigators, either through regulatory modifications, logistical modifications, additions to the service menu, or in creating solutions to challenging research problems.

摘要 – 生物样本核心生物样本核心对于获取所有生物样本、验证“正常健康组织”至关重要诊断、处理和分配所需的所有组织和相关生物液体/非组织标本 SCENT 整合了多个成熟的杜克大学机构以及高度专业化的协作机构。能力是该核心的独特优势，我们是国家认可的生物样本库，也是最高水平的生物样本库之一。该国的器官移植中心的活动与标准护理同时进行。活检、预定外科手术、尸检和器官捐献者采购本核心的目标。是提供生物样本服务与卓越的质量控制措施，以实现细胞的组织图谱该核心将在整个生命周期（胎儿/围产期到老年人）中检测正常健康组织中的衰老生物标志物。由尸检、器官捐献和手术组织采购方面具有专业知识的团队领导。为了实现目标，我们将努力 1) 有效识别、获取和验证高质量正常健康组织的诊断以及基于严格标准的并发生物流体/非组织样本，2) 处理高质量的正常健康样本组织进行相关分析，3) 确保样品管理的质量保证和质量控制，样本跟踪和生物样本库信息学管理，为所有 SenNet 提供最佳的样本库组织共享我们的长期目标是不断发展以满足我们研究人员的需求。通过监管修改、物流修改、服务菜单添加或创建解决方案具有挑战性的研究问题。