Biospecimen Core

生物样本核心

基本信息

批准号：
10492752
负责人：
Carolyn Glass
金额：
$ 51.15万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10492752
关键词：
Academic Medical Centers Accreditation Age Ambulatory Care Facilities Atlases Autopsy Biological Biological Assay Biological Markers Biopsy Blood specimen Bronchoscopy Cardiac Surgery procedures Cell Aging Cells Childhood Clinic Clinical Clinical Data Clinical Trials Collaborations Collection Colon Communities Consent Consent Forms Country Coupled Data Diagnosis Elderly Endoscopy Enrollment Ensure Epidemiology Evaluation Exposure to Faculty Fresh Tissue Funding Gastroenterology Goals Health Heart Heart Transplantation Heterogeneity Home Hospitals Individual Infant Informatics Institution International Intervention Investigation Laboratories Language Liquid substance Logistics Longevity Lung Lung Transplantation Maps Measures Mitotic Modification Molecular Muscle Normal tissue morphology Operative Surgical Procedures Organ Organ Donor Organ Transplantation Participant Pathologic Pathologist Pathology Perinatal Phase Population Practice Guidelines Predisposition Procedures Process Proliferating Protocols documentation Pulmonology Quality Control Race Regulation Research Research Personnel Research Support Resource Sharing Sampling Schedule Secure Services Skin Socioeconomic Status Somatic Mutation Source Specimen Swab Tissue Banks Tissue Procurements Tissues Training United States Work age group base biobank body system clinically relevant cohort data sharing demographics environmental stressor fetal gender diversity human tissue interest middle age peripheral blood programs prospective quality assurance real time monitoring recruit saliva sample scale up senescence standard of care stem cells stool sample tissue mapping tissue resource transplant centers

项目摘要

ABSTRACT – Biospecimen Core The Biospecimen Core is essential for the acquisition of all biospecimens, verification of “normal healthy tissue” diagnosis, processing and allocation of all tissue and associated biofluids/non-tissue specimens required for SCENT. Integration of multiple, well-established Duke institutions with highly specialized collaborative capabilities is a unique strength of this Core. We are a nationally recognized biorepository and one of the highest organ transplantations centers in the country. Biobanking activities occur in parallel with standard of care biopsies, scheduled surgical procedures, autopsies and organ donor procurements. The objective of this Core is to provide biospecimen services with exceptional quality control measures to enable tissue mapping of cellular senescence biomarkers in normal healthy tissues across the lifespan (fetal/perinatal to elderly). This Core will be led by a team with expertise in autopsy, organ donor and surgical tissue procurement. To accomplish our goals, we will work to 1) efficiently identify, procure and verify diagnoses of high-quality normal healthy tissue and concurrent biofluids/non-tissue specimens based on stringent criteria, 2) process high-quality normal healthy tissues for correlative analyses and 3) ensure quality assurance and quality controls for sample management, specimen tracking and biobanking informatics management for optimal banked tissue sharing for all SenNet funded institutions. Our long-term goal is to constantly evolve to meet the needs of our investigators, either through regulatory modifications, logistical modifications, additions to the service menu, or in creating solutions to challenging research problems.

摘要 - 生物循环核心生物测量核心对于获得所有生物测量，“正常健康组织”的验证至关重要所有组织和相关的生物流体/非组织样本的诊断，加工和分配香味。将多个公认的公爵机构与高度专业的合作集成功能是该核心的独特优势。我们是全国认可的生物座席，也是最高的生物座席之一器官移植以该国为中心。生物库活动与标准护理同时发生活检，计划的手术程序，尸检和器官捐赠者采购。这个核心的目的是为生物循环服务提供出色的质量控制措施，以实现细胞的组织映射整个寿命正常健康组织中的衰老生物标志物（胎儿/围产期至较早）。这个核心将由具有尸检，器官捐赠者和外科组织采购方面的专业知识的团队领导。完成我们的目标，我们将工作至1）有效识别，采购和验证高质量正常健康组织的诊断以及基于严格标准的同时生物流体/非组织标本，2）过程高质量的正常健康进行相关分析的组织和3）确保样本管理的质量保证和质量控制，标本跟踪和生物群信息信息管理，用于所有Sennet的最佳银行组织共享资助的机构。我们的长期目标是不断发展以满足调查人员的需求通过监管修改，后勤修改，对服务菜单的添加或创建解决方案挑战研究问题。