Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis

早期体内表达的抗原及其在球孢子菌病毒力、免疫反应和疫苗中的作用

• 批准号: 10689664
• 负责人: Paul Stephen Keim
• 金额: $ 25.84万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-24 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689664
• 关键词: Accounting; Animal Model; Antigens; Area; Arizona; Award; Budgets; Businesses; Clinical; Coccidioidomycosis; Collaborations; Communication; Communities; Data; Development; Diagnostic; Ensure; Evaluation; Faculty; Familiarity; Feedback; Fostering; Funding; Goals; Human Resources; Immune response; Individual; Institution; Joints; Knowledge; Lead; Leadership; Length; Life; Location; Medical center; Mentors; Monitor; National Institute of Allergy and Infectious Disease; Office of Administrative Management; Performance; Pilot Projects; Postdoctoral Fellow; Primates; Productivity; Publications; Reporting; Research; Research Institute; Research Project Grants; Resources; Role; Schedule; Scheme; Series; Services; Structure; Students; Time; Training; Travel; United States National Institutes of Health; Universities; Vaccines; Video Recording; Videoconferencing; Virulence; Washington; Work; clinical trial readiness; collaborative environment; desert fever; early-career faculty; experience; in vivo; innovation; meetings; member; novel vaccines; outreach; programs; research and development; student mentoring; success; synergism; timeline; translational genomics; virtual; working group

Administrative Core Section SUMMARY The Virulence, Immune Response, and Vaccine (VIRV) Cocci Cooperative Research Center (CCRC) will be directed by the administrative core (AdC) and a senior management team (SMT). The SMT is composed of Drs. Paul Keim (overall PI/PD), Bridget Barker, Deborah Fuller, and Erik Settles – all experienced scientific project managers. This is an aggregate effort by Northern Arizona University, University of Washington, the University of Arizona, the Kern Medical Center, the Tulane National Primate Research Center, and the Translational Genomics Research Institute that will capitalize upon the strengths of each institution and will synergistically foster a collaborative and productive scientific culture. Because it is a multi-Institutional program, coordination and communication are essential and will be an emphasis in the AdC. All of the individual Cores and Research Projects (RPs) will be represented on the SMT, which will provide effective vertical and horizontal communication, and management. Weekly meetings will be held within each of the CCRC components in addition to regular monthly cross-CCRC sessions to foster engagement and collaboration across the projects. All meetings will be supported by video conferencing and recorded, to lower participation barriers across the physical research locations. Slack accounts and channels will be an important part of the management communication scheme. Financial and compliance monitoring, along with reporting activities of the Cores and RPs, will be managed by the AdC, which includes a project manager with business accounting support. Major services, such as publication, animal models, and travel will be funded through the Cores to support the three individual RPs. Milestones and Timelines will be generated for each component and reviewed monthly during the SMT meetings. Outreach activities will be assessed and are part of the success metrics. Integral to these CCRC coordination efforts will be our program in Development Research Projects (DRPs) that will foster early career faculty, cross CCRC participation, and innovative ideas. The AdC will solicit, evaluate, award, and monitor the DRPs throughout the life of the VIRV-CCRC. Outreach will include our virtual seminar program and online forums to support the Valley Fever clinical and research communities, particular to other NIAID CCRC’s. Professional development, training, and mentoring of students, postdoctoral fellows, and junior faculty will be encouraged and supported by the AdC. Scientific working groups within and across the NIAID Cocci Centers will be fostered with the seminar series, travel funds, and joint pilot projects. The VIRV-CCRC team members will be expected to collaborate extensively and to produce relevant and impactful scientific products, including potentially a novel vaccine ready for clinical trials.

行政核心部分 概括 毒力，免疫反应和疫苗（VIRV）COCCI合作研究中心（CCRC）将是 由行政核心（ADC）和高级管理团队（SMT）指导。 博士。保罗·凯姆（Paul Keim 项目经理。 亚利桑那大学，克恩医学中心，杜兰国家灵长类动物研究中心和你 转化基因组学研究所的大写构成了每种工厂的力量机构和意志威尔尔 协同培养一种协作和生产性的科学文化。 计划，协调和沟通是必不可少的，将是ADC的重点 单个核心和研究项目（RPS）将在SMT上代表，该项目将提供有效 垂直和水平沟通以及每周举行的会议 CCRC组件除了定期每月跨CCRC会话以促进参与和 整个项目的合作将由视频会议支持，并记录下来 较低的物理研究地点的参与障碍将是一个 管理沟通学校的重要一部分 核心和RP的报告活动将由ADC管理，其中包括项目经理 提供业务会计支持，例如出版物，动物模型和旅行 通过核心资助以支持三个单独的RPS和时间表。 对于每个组件，并在SMT会议期间每月审查。 这是CCRC协调工作不可或缺的成功指标的一部分 开发研究项目（DRP）将培养早期职业教师，交叉CCRC参与和 创新的想法。 VirV-CCRC。 发烧的临床和研究社区，尤其是其他NIAID CCRC。 培训和指导学生，博士后研究员和初级教师将受到鼓励和 由ADC支持。 通过研讨会系列，旅行基金和联合飞行员项目。 预计将进行广泛的合作，并产生相关和有影响力的科学方面，包括 可能是一种新型疫苗，准备进行临床试验。