Lifecourse Community Contexts and Health Behaviors as Drivers of Disparities in Risk of Alzheimer's Disease and Related Dementias

生命历程社区背景和健康行为是阿尔茨海默病和相关痴呆风险差异的驱动因素

• 批准号: 10689256
• 负责人: Rachel Lynne Peterson
• 金额: $ 24.22万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689256
• 关键词: Address; Adult; Affect; Age; Alzheimer' s Disease Pathway; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amygdaloid structure; Amyloid; Amyloid beta-Protein; Area; Asian population; Atlases; Award; Behavior Therapy; Behavioral; Biological Factors; Birth History; Black Populations; Brain; California; Censuses; Childhood; Clinical Trials; Cognition; Cognitive; Communities; County; Data; Databases; Dementia; Diet; Disparity; Dose; Economics; Elderly; Epidemiology; Ethnic Origin; Exposure to; Failure; Funding; Future; Gender; Geography; Goals; Green space; Health; Health Benefit; Health Promotion; Health behavior; Hippocampus; Impaired cognition; Individual; Influentials; International; Latino Population; Libraries; Life Cycle Stages; Life Experience; Life Style; Link; Magnetic Resonance Imaging; Measures; Mediating; Mentorship; Methods; Modeling; Neighborhoods; Observational Study; Outcome; Participant; Pathway interactions; Physical activity; Play; Policies; Population; Population Intervention; Positron-Emission Tomography; Public Health; Race; Research; Risk Factors; Risk Reduction; Science; Shapes; Social Environment; Socioeconomic Status; Testing; Training; Translating; United States National Institutes of Health; Universities; Work; aging brain; brain health; built environment; cardiometabolism; career; cohort; community center; contextual factors; dementia risk; deprivation; farmers markets; health disparity; healthy aging; indexing; innovation; insight; modifiable risk; neighborhood disadvantage; neuroimaging; neuroimaging marker; physical inactivity; population based; protective behavior; psychologic; response; social; social determinants; social epidemiology; social health determinants; socioeconomics; walkability

PROJECT SUMMARY/ABSTRACT Alzheimer's disease and related dementias (ADRD) are a pressing public health issue with substantial disparities. ADRD can only be addressed by minimizing the impact of modifiable risk factors – especially health behaviors. However, evidence suggests that health behaviors are shaped by the community contexts (i.e. built and social environments) in which we live, work, play, and age. Failure to understand and account for community- level contextual factors in ADRD risk reduction may minimize the impact of public health measures to reduce the risk of ADRD and worsen health disparities. Investigating pathways that connect community contextual factors, health behavior engagement, and disparities in ADRD risk is an untapped opportunity to advance the science ADRD risk reduction, and is aligned with NIA's strategic goals by “illuminat(ing) the pathways by which social, psychological, economic, and behavioral factors affect health,” and “understand(ing) environmental, social, cultural, behavioral, and biological factors that create and sustain health disparities.” This study leverages data from two innovative projects funded by the NIH (Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE); Neighborhood Atlas) and the PolicyMap database to identify when and how community contextual factors shape health behaviors and ADRD risk and disparities. This project will link KHANDLE participants' residential histories from birth to late-life with the validated Area Deprivation Indices available via the Neighborhood Atlast from 1910 to present, and geocoded measures of the built environment available via PolicyMap. This proposal seeks to define: 1) how the timing or duration of exposure to community contexts is associated with late-life cognitive/brain health; 2) if individual health behaviors mediate relationships between community contexts and cognitive/brain health; 3) if these pathways differ by race/ethnicity or gender. This research is complimented by a detailed training plan at the University of California Davis guided by a mentorship team comprised of nationally and internationally recognized scholars. The training will build upon the applicant's background in social epidemiology, health promotion, and healthy brain aging research to incorporate new training in causal inference methods, geospatial analysis, modeling neuroimaging biomarkers, and translational epidemiology. The combined research and training will prepare the applicant for a successful independent research career focused on understanding and addressing modifiable pathways for ADRD disparities. Findings from the proposed research are critical for advancing population based ADRD risk reduction strategies that eliminate, rather than exacerbate, health disparities.

项目摘要/摘要 阿尔茨海默氏病和相关痴呆症（ADRD）是一个紧迫的公共卫生问题 差距。 然而，有证据表明，众所周知是由社区背景所塑造的 和社交环境）我们的生活，工作，游戏和年龄都无法理解和解释社区 降低ADRD风险的级别上下文因素可能会最大程度地减少公共卫生措施的影响以减少您 ADRD的风险和健康差异都会恶化。 健康行为参与和ADRD的差异是推进科学的未开发的机会 降低风险的风险，并通过“ Illuminat（Ink）社会，社会的途径，与NIA的战略目标保持一致 心理，经济和行为因素影响健康 造成和维持健康差异的文化，行为和生物学因素” 这项研究利用了NIH资助的两个创新项目（Kaiser Healthy Seving and Diversey）的数据 生活经验（Khandle）； 社区上下文因素塑造健康行为和风险磁盘差异。 Khandle参与者的住宅历史从出生到后期，有验证的地区剥夺。 从1910年到现在，可通过附近的Atlast提供，并采取了构建环境的地理编码措施 可通过策略合成。 情境与晚期认知/大脑健康有关； 2） 在社区环境和认知/大脑健康之间； 加利福尼亚大学戴维斯分校的详细培训计划汇编了这项研究 国家和国际认可的学校的指导团队组成。 申请人在社会流行病学，健康促进和健康的大脑衰老研究中的背景 因果推断方法，地理空间分析，神经影像学生物标志物以及以及 翻译流行病学。 独立研究职业专注于理解和解决ADRD 差距。 消除而不是加剧健康差异的策略。