Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study

女性癌症的长期多学科研究：护士健康研究

基本信息

批准号：
10688005
负责人：
A. Heather Eliassen
金额：
$ 150.07万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10688005
关键词：
Address Adjuvant Therapy Age Age Years Aging Archives Behavior Behavioral Behavioral Research Biological Biological Markers Blood Blood specimen Brain Cancer Etiology Cancer Patient Cancer Survivor Cancer Survivorship Caring Cells Cessation of life Collaborations Collection Communities DNA Data Data Analyses Data Element Databases Diagnostic Diet Documentation Educational Materials Enrollment Environment Erythrocytes Etiology Fostering Funding Genetic Predisposition to Disease Genomics Genotype-Tissue Expression Project Goals Guidelines Health Health Policy Incidence Information Systems Infrastructure International Life Cycle Stages Life Style Link Malignant Neoplasms Malignant neoplasm of ovary Mammography Measures Mediating Medicare claim Modernization Multiple Cancer Sites Neighborhoods Nurses&apos Health Study Nursing Research Outcome Participant Patients Phase Phenotype Physical activity Plasma Population Process Publications Quality of life Questionnaires Recurrence Registries Research Research Personnel Resource Sharing Resources Sampling Scientist Serous Specimen Structure of nail of toe System The Cancer Genome Atlas Tissue Banks Tissues Tumor Tissue Update Urine Visualization Woman biobank biological research cancer epidemiology cancer prevention cancer risk cancer site cancer survival cancer therapy clinical practice cohort complex data cost data management data resource data sharing data tools data visualization follow-up genomic data health data human old age (65+)indexing large datasets middle age mortality multidisciplinary neoplasm registry neoplasm resource novel repository research study screening tool tumor user-friendly virtual

项目摘要

ABSTRACT This is a competing renewal of a UM1 application to support the infrastructure of the original Nurses’ Health Study (NHS), begun in 1976. The accumulated resources of NHS provide exceptional opportunities for identifying new paradigms in cancer prevention, etiology and survival. The resources encompass: lifestyle, diet and health data from 20 biennial questionnaires spanning 4 decades from 121,700 women; linked residential data on environment and neighborhood; blood samples from 32,826 participants in mid-life; a 2nd blood and morning urine in 18,743 of these women 10 years later; buccal cells from 33,040 women without blood; 62,641 toenail samples; 6,027 pre-diagnostic mammograms; tissue blocks from >14,000 patients across 16 cancers. The scientific contributions of NHS have been equally exceptional. During this funding period, accomplishments include: >400 cancer-related publications; nearly 300 resource-sharing projects by external investigators and pooling projects/consortia (a 130% increase since 2014); and participation in 33 cancer consortia, including 22 NCI consortia. Most importantly, NHS research has meaningfully guided national and international cancer guidelines on issues ranging from diet to adjuvant treatment. Our overarching goals here are to (1) efficiently expand resources with collection of key new data elements and specimens, and (2) maximize the application and sharing of existing resources, facilitating their transformation into novel cancer discoveries. First, NHS women are now >70 years of age. Over 1/3 of cancers in the US occur after age 75, and half of cancer survivors are 70+ years. Many cancer phenotype distributions appear to change with age (e.g., serous ovarian cancer becomes more common). Moreover, in the next 15 years, the proportion of the US population >70 years will grow by 60%. Thus, continued data and tumor tissue collection in NHS is critical to inform new behavioral and biological research on cancer etiology, survival and quality of life in aging. Specifically, in the next funding period, we will continue to: collect questionnaire data on behavior, quality of life, and health in aging; document cancers/ deaths; link with cancer and death registries, and Medicare claims to enhance follow-up; maintain our bio- repository; collect new tissue blocks. Second, we have had great accomplishments in data use/sharing, but this could be further increased to harness the brain-power of more cancer scientists. Mastering the large, complex data systems with decades of accumulated data elements is a challenge that inhibits efficiency of data sharing. In the next funding period, we propose to update and modernize our data systems, to grow support a large community of users via user-friendly tools for data management, visualization, and analysis. This will be done in an exciting collaboration with The Broad Institute, which is leading and developing similar platforms for The Cancer Genome Atlas, the Genotype-Tissue Expression (GTEx) project, and others.

抽象的这是 UM1 应用程序的竞争性更新，旨在支持原始护士健康的基础设施研究 (NHS)，始于 1976 年。NHS 积累的资源为确定癌症预防、病因学和生存的新范例。这些资源包括：生活方式、饮食。以及来自 20 份为期 40 年、针对 121,700 名居住女性的两年期调查问卷的健康数据；有关环境和社区的数据；来自 32,826 名中年参与者的血液样本； 10 年后，其中 18,743 名女性的晨尿；来自 33,040 名没有血液的女性的颊细胞；脚趾甲样本；来自超过 14,000 名癌症患者的 6,027 个诊断前组织块。在此资助期间，NHS 的科学贡献同样出色。成就包括： > 400 份与癌症相关的出版物；近 300 个资源共享项目外部调查员和联合项目/联盟（自 2014 年以来增加了 130%）和参与； 33 个癌症联盟，包括 22 个 NCI 联盟最重要的是，NHS 研究提供了有意义的指导。关于从饮食到辅助治疗等问题的国家和国际癌症指南。我们的首要目标是 (1) 通过收集关键新数据来有效扩展资源元素和标本，（2）最大限度地利用和共享现有资源，首先，NHS 女性现在已经超过 70 岁了。在美国，超过 1/3 的癌症发生在 75 岁之后，一半的癌症幸存者年龄超过 70 岁。癌症表型分布似乎随年龄而变化（例如，浆液性卵巢癌变得更此外，未来15年，美国70岁以上人口比例将增长60%。因此，NHS 中持续的数据和肿瘤组织收集对于为新的行为和生物学提供信息至关重要。具体来说，在下一个资助期内，我们将进行癌症病因学、生存率和生活质量方面的研究。继续：收集有关老年行为、生活质量和健康的问卷数据；死亡；与癌症和死亡登记处联系，医疗保险声称加强随访；其次，我们在数据使用/共享方面取得了巨大成就，但是。这可以进一步增加，以利用更多癌症科学家的脑力来掌握大型、具有数十年积累的数据元素的复杂数据系统是一个挑战，它抑制了效率在下一个资助期内，我们建议更新和现代化我们的数据系统，以实现增长。通过用户友好的数据管理、可视化和分析工具支持大型用户社区。这将通过与布罗德研究所的令人兴奋的合作来完成，该研究所正在领导和开发类似的癌症基因组图谱、基因型组织表达 (GTEx) 项目等的平台。

项目成果

期刊论文数量（161）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Genetic determinants of liking and intake of coffee and other bitter foods and beverages.

DOI：
10.1038/s41598-021-03153-7
发表时间：
2021-12-13
期刊：
Scientific reports
影响因子：
4.6
作者：
Cornelis MC;van Dam RM
通讯作者：
van Dam RM

Urinary Melatonin in Relation to Postmenopausal Breast Cancer Risk According to Melatonin 1 Receptor Status.

DOI：
10.1158/1055-9965.epi-16-0630
发表时间：
2017-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
0
作者：
Devore EE;Warner ET;Eliassen AH;Brown SB;Beck AH;Hankinson SE;Schernhammer ES
通讯作者：
Schernhammer ES

Utility of inverse probability weighting in molecular pathological epidemiology.

DOI：
10.1007/s10654-017-0346-8
发表时间：
2018-04
期刊：
European journal of epidemiology
影响因子：
13.6
作者：
Liu L;Nevo D;Nishihara R;Cao Y;Song M;Twombly TS;Chan AT;Giovannucci EL;VanderWeele TJ;Wang M;Ogino S
通讯作者：
Ogino S

Endometrial Tumor Classification by Histomorphology and Biomarkers in the Nurses' Health Study.