Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients

基于 6200 万成年患者电子健康记录的实时分析，描述 COVID-19 与酒精使用障碍之间的多方面相互作用

• 批准号: 10687823
• 负责人: Pamela B Davis
• 金额: $ 36.23万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10687823
• 关键词: 18 year old; 2019-nCoV; Adult; Affect; Age; Alcohol consumption; Alcohols; American; Anxiety; Area; Behavioral; Bereavement; Biological; COVID-19; COVID-19 pandemic effects; COVID-19 patient; COVID-19 risk; COVID-19 survivors; COVID-19 susceptibility; Cannabis; Categories; Centers for Disease Control and Prevention (U.S.); Central Nervous System; Cessation of life; Cocaine; Cognitive; Complex; Consumption; Crowding; Databases; Diagnosis; Disease; Economic Burden; Electronic Health Record; Evolution; Family; Feeling suicidal; Frequencies; Fright; General Population; Grief reaction; Heart Diseases; Heavy Drinking; Hospitalization; Human; Impairment; Income; Infection; Intervention; Investigation; Malignant Neoplasms; Measures; Medical; Mental Depression; Mental Health; Mental disorders; Neurologic; Opioid; Organism; Outcome; Patients; Post-Traumatic Stress Disorders; Prevalence; Psyche structure; Psychoses; Public Health; Risk; SARS-CoV-2 infection; Sales; Schizophrenia; Site; Social isolation; Stimulant; Substance Use Disorder; Survivors; Testing; Time; Tobacco; Update; Variant; Virus; Virus Diseases; Workplace; alcohol risk; alcohol use disorder; chronic liver disease; comorbidity; coronavirus disease; cost; electronic health database; gender disparity; high risk; pandemic disease; prevent; racial disparity; response; social; social contact; synergism; therapy design; vaccine hesitancy; viral transmission

PROJECT SUMMARY During the pandemic, with social isolation and grief as drivers, alcohol consumption is increasing. SARS-CoV-2 itself has substantial impact on the central nervous system. When two such important public health menaces intersect, it is crucial to understand their interaction and potential synergy. In this project titled “Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patients”, we propose to: 1) characterize susceptibility to COVID-19 in patients with alcohol use disorder (AUD) (“AUD → COVID-19”), consider racial and gender disparity, and follow its evolution over time; 2) characterize how COVID-19 infection and the social pandemic context impact the risk of AUD (“COVID-19 plus pandemic context → AUD”), consider racial and gender disparity, and follow these changes over time; and 3) characterize prevalence of major psychiatric disorders, other substance use disorders and severe outcomes among patients with both AUD and COVID-19 (“AUD+COVID-19 → outcomes”) and to follow these outcomes over time. Our studies will identify potential areas for timely interventions to protect patients or mitigate the worst effects of COVID-19 pandemic and AUD, singly and combined. This is especially important if there should be another surge with a virus variant, or if vaccine hesitancy is greater in those with AUD. It will also inform such studies if we have another pandemic with another organism, for the approaches we pioneer in these studies using nation-wide database of electronic health records may pave the way for rapid, real-time analytics and results to inform our control measures.

项目摘要 在大流行期间，由于社会隔离和贪婪，饮酒量正在增加。 SARS-CoV-2 本身对中枢神经系统有重大影响。当两个如此重要的公共卫生威胁 相交，了解它们的相互作用和潜在的协同作用至关重要。在这个标题为“特点的项目”中 基于对实时分析 6200万成人患者的电子健康记录”，我们建议：1）表征对 COVID-19患有酒精使用障碍患者（AUD）（“ AUD→COVID-19”），考虑种族和性别 差异，并随着时间的流逝而遵循其进化； 2）表征19 covid-19的感染和社会大流行如何 上下文会影响AUD的风险（“ Covid-19 Plus大流行环境→AUD”），考虑种族和性别 差异，并随着时间的推移遵循这些变化； 3）特征是主要精神疾病的患病率， AUD和Covid-19的其他药物使用障碍和严重结果 （“ aud+covid-19→结果”）并随着时间的推移遵循这些结果。我们的研究将确定潜力 及时干预措施以保护患者或减轻COVID-19大流行和AUD的最严重影响的区域， 单独合并。如果应该有另一种病毒变体的激增，或者 疫苗的犹豫较大，其中有AUD的人会更大。如果我们还有另一个大流行，它也将为此类研究提供信息 对于另一种生物体，对于我们在这些研究中使用的方法，使用了全国范围的数据库 电子健康记录可能为快速，实时分析和结果铺平道路，以告知我们的控制 措施。