Study to Uncover Pathways to Exceptional Cognitive Resilience in Aging (SUPERAging)

研究揭示衰老过程中卓越认知弹性的途径（SUPERAging）

• 批准号: 10687271
• 负责人: CHANGIZ GEULA
• 金额: $ 127.95万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10687271
• 关键词: Acceleration; Address; Age; Aging; Alzheimer' s Disease; Alzheimer’s disease biomarker; Anatomy; Behavioral; Biological; Biology; Biometry; Biostatistics Core; Black race; Brain; Brain Diseases; Canada; Clinical; Cognition; Cognitive; Cognitive aging; Collaborations; Databases; Dementia; Diagnosis; Digital biomarker; Elderly; Enrollment; Extramural Activities; Funding; Genetic; Goals; Health; Illinois; Image; Immune; Impaired cognition; Individual; Inflammatory; Infrastructure; Investigation; Leadership; Life; Memory; Michigan; Molecular; Nerve Degeneration; Neurobiology; Neurons; Neuropsychology; Ontario; Outcome; Participant; Pathologic; Pathway interactions; Pattern; Performance; Peripheral; Phenotype; Physical activity; Physiological; Plasma; Procedures; Psychophysiology; Race; Research; Research Personnel; Research Project Grants; Resistance; Site; Sleep; Specimen; Standardization; Structure; System; Testing; United States; Wisconsin; age related; behavioral neurology; blood product; brain tissue; case control; cohort; comparison control; demographics; genetic profiling; human old age (65+); minority communities; multidisciplinary; neuroimaging; neuropathology; novel; organizational structure; preservation; prevent; programs; protein profiling; psychosocial; racial diversity; recruit; resilience; response; social engagement; socioeconomics; temporal measurement; transcriptomic profiling; wearable device

PROJECT SUMMARY (Overall): The primary goal is to establish a multicenter SuperAging Consortium to identify behavioral, health, biologic, genetic, environmental, socioeconomic, psychosocial, anatomic and neuropathologic factors associated with SuperAging. These goals will be achieved through an organizational structure with 3 Cores (Administrative/Biostatistics, Clinical/Imaging, and Biospecimen/Neuropathology) and 2 Research Projects. The Consortium will enroll 500 participants across 4 US Sites located in Illinois, Wisconsin, Michigan and Georgia, and the Canadian Site in Southwest, Ontario, with a focus on the enrollment of Black SuperAgers and Cognitively Average Elderly Controls with similar demographics (Controls). The Administrative/Biostatistics Core will provide governance and fiscal oversight, maintain scientific integrity, and create a centralized biostatistics and database infrastructure to harmonize the goals and activities of the Cores, Sites, and Projects, with each other, with the NIA and with extramural collaborators. The Clinical/Imaging Core will standardize criteria for the uniform cross-site and multidisciplinary characterization of SuperAgers, streamline recruitment including that of Black participants, enter relevant information in the comprehensive database, support co-enrollment into Project 1, and encourage collaborative ventures aiming to understand the factors that promote SuperAging. The Biospecimen/Neuropathology Core will collect and bank brain tissue and blood products from SuperAging and Control cases, according to optimized procedures. It will render pathological diagnoses, quantitate selected markers of neurodegeneration and neuronal structure, coordinate the analyses of plasma biomarkers for Alzheimer's disease, and make specimens available for collaborative investigations. Project 1 will use state-of- the-art wearable technology to obtain real-time measurements in the course of everyday life to characterize quantitative parameters related to sleep, physical activity, autonomic responsivity, and social engagement to determine whether SuperAgers have relatively preserved and quantitatively determined physiologic and behavioral `complexity' compared to Controls. Project 2 will use transcriptomic, genetic, and protein profiling approaches to test the hypothesis that SuperAgers will demonstrate significant molecular differences in their central and peripheral immune and inflammatory system parameters compared to matched Control and Alzheimer's disease participants. By identifying neurobiologic features that contribute to superior memory performance in old age, outcomes from this Consortium will help isolate factors that promote successful cognitive aging and perhaps also prevent age-related brain diseases such as Alzheimer's disease.

项目摘要（总体）： 主要目标是建立一个多中心超级老龄化联盟，以识别行为、健康、生物、 与相关的遗传、环境、社会经济、心理社会、解剖学和神经病理学因素 超级老化。这些目标将通过具有 3 个核心的组织结构来实现 （行政/生物统计学、临床/成像和生物样本/神经病理学）和 2 个研究项目。这 联盟将在位于伊利诺伊州、威斯康星州、密歇根州和佐治亚州的 4 个美国站点招募 500 名参与者， 以及位于安大略省西南部的加拿大站点，重点关注黑人超级老年人和认知方面的入学 具有相似人口统计数据的平均老年人对照（对照）。行政/生物统计核心将 提供治理和财政监督，维护科学完整性，并创建集中的生物统计和 数据库基础设施，以协调核心、站点和项目的目标和活动， 与 NIA 和校外合作者合作。临床/影像核心将标准化标准 对超级老年人进行统一的跨地点和多学科特征描述，简化招聘，包括 黑人参与者，在综合数据库中输入相关信息，支持共同报名加入项目 1、鼓励旨在了解促进超级老龄化的因素的合作企业。这 生物样本/神经病理学核心将从 SuperAging 收集并储存脑组织和血液制品 根据优化程序控制病例。它将提供病理诊断、定量选择 神经变性和神经元结构的标记物，协调血浆生物标记物的分析 阿尔茨海默病，并提供样本用于合作研究。项目 1 将使用 state-of- 最先进的可穿戴技术，可在日常生活中获得实时测量结果来表征 与睡眠、身体活动、自主反应和社会参与相关的定量参数 确定超级老年人是否具有相对保留和定量确定的生理和 与对照组相比，行为“复杂性”。项目 2 将使用转录组、遗传和蛋白质分析 方法来检验“超级老年人”将在其体内表现出显着的分子差异的假设 与匹配的对照组和对照组相比，中枢和外周免疫和炎症系统参数 阿尔茨海默病参与者。通过识别有助于卓越记忆的神经生物学特征 老年表现，该联盟的结果将有助于分离促进成功认知的因素 衰老，也许还可以预防与年龄相关的脑部疾病，例如阿尔茨海默病。