Neurobiological and psychobiological signatures of vocal effort in early career teachers

早期职业教师发声努力的神经生物学和心理生物学特征

基本信息

批准号：
10687044
负责人：
MARIA DIETRICH
金额：
$ 42.79万
依托单位：
UNIVERSITY HOSPITAL BONN
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10687044
关键词：
Acoustics Address Age Algorithms Amygdaloid structure Anterior Aphonia Area Behavioral Behavioral inhibition Brain Case Study Classification Clinical Conversion disorder Cues Data Data Collection Data Correlations Dysphonia Educational process of instructing Electrodes Electromyography Event Exposure to Fatigue Female Functional Magnetic Resonance Imaging Functional disorder Goals Hydrocortisone Individual Individual Differences Intervention Introversion Knowledge Laryngeal muscle structure Larynx Magnetic Resonance Imaging Manuals Meditation Motor Motor Cortex Muscle Muscle Tension Neck Neurobiology Participant Pathway interactions Patient Self-Report Patients Pattern Pattern Recognition Peripheral Personality Persons Preventive measure Production Protocols documentation Quality of life Reaction Recurrence Research Risk Role Salivary Sampling Skinfold Thickness Speech Speech Disorders Stress Students Subgroup Surface Technology Transcranial magnetic stimulation Treatment Efficacy Voice Voice Disorders Voice Quality acute stress behavior measurement behavioral response career clinically relevant cohort experimental study improved indexing innovation insight interest introvert motor control nervous system disorder neural neural correlate neurobiological mechanism neurological rehabilitation novel programs psychobiologic responders and non-responders social stress reactivity stressor success teacher theories trait vocal cord vocalization

项目摘要

Project Summary Muscle tension voice disorders such as primary muscle tension dysphonia (pMTD) are common and can profoundly impact quality of life. Precipitating events such as stress and introverted personality are possible factors in pMTD according to the trait theory of voice disorders. This theory proposed neurobiological mechanisms involving behavioral inhibition, but the condition remains an unclassified voice disorder with unknown causes. Large-scale research into the functional and clinical relevance of stressor-dependent limbic- motor interactions using functional MRI (fMRI) to support a neural basis for pMTD is missing. The aims of the project are to (1) determine the functional relevance of stressor-induced limbic activations on the control of voice in the brain in vocally healthy controls, (2) determine the clinical relevance of stressor-induced limbic activations on the control of voice in the brain in those with and without vocal fatigue, and (3) classify extralaryngeal muscular surface electromyography (sEMG) patterns of stress responders and nonresponders with and without vocal fatigue. Sixty female controls and thirty female early career teachers with vocal fatigue (based on Vocal Fatigue Index) between 21-39 years will read sentences with and without exposure to a speech anticipation stressor using a sparse-sampling event-related fMRI protocol. Salivary cortisol analyses will reveal cortisol stress responders and nonresponders. Participants will wear MRI-compatible sEMG electrodes on the anterior neck and complete a corresponding sEMG speech production protocol, but without stressor exposure, outside the scanner on a separate day. Audio data will be recorded to determine changes in vocal effort during speech production. fMRI activations in the laryngeal motor cortex and functional connectivity of core limbic regions will be determined. Further, sEMG patterns of subgroups will be classified, compared, and the total sEMG data correlated with neural (fMRI), psychobiological (cortisol, personality), and vocal function (acoustic) data for all participants and subgroups. The central hypothesis is that laryngeal stress responders have heightened limbic-motor activations involving the limbic vocalization pathway, which correlate with changes in extralaryngeal sEMG activity. In sum, this innovative project will determine neural, psychobiological, and vocal function signatures of stress responders and nonresponders in early career teachers with vocal fatigue and controls. The results will provide fundamentally missing data in our understanding of the role of stress in vocal complaints and will yield new insights about the neural correlates of pMTD. The study findings will have a significant impact on how we identify laryngoresponders for preventative measures and optimize the long-term success of interventions for a broad range of behavioral voice and speech disorders under consideration of neurorehabilitative interventions such as meditation and transcranial magnetic stimulation and wearable sEMG technology.

项目概要肌张力性发声障碍，例如原发性肌张力性发声障碍 (pMTD) 很常见，并且可能会导致发声障碍。深刻影响生活质量。压力和内向性格等突发事件是可能的根据声音障碍的特质理论，影响 pMTD 的因素。该理论提出了神经生物学涉及行为抑制的机制，但这种情况仍然是一种未分类的声音障碍原因不明。对应激源依赖性边缘系统的功能和临床相关性的大规模研究缺少使用功能性 MRI (fMRI) 来支持 pMTD 神经基础的运动相互作用。该组织的目标项目的目的是（1）确定压力源引起的边缘激活对控制的功能相关性声音健康对照者大脑中的声音，（2）确定压力源引起的边缘系统的临床相关性有或没有声音疲劳的人大脑中声音控制的激活，以及（3）分类应激反应者和无反应者的喉外肌肉表面肌电图 (sEMG) 模式有或没有声音疲劳。六十名女性对照者和三十名女性早期职业教师患有声音疲劳（基于声音疲劳指数）21-39 岁的人会在有或没有接触过声音的情况下阅读句子使用稀疏采样事件相关的功能磁共振成像协议来预测言语预期压力源。唾液皮质醇分析将揭示皮质醇应激反应者和无反应者。参与者将佩戴 MRI 兼容的 sEMG 前颈上的电极并完成相应的表面肌电图语音产生协议，但没有压力源暴露，在另一天扫描仪外。音频数据将被记录以确定变化言语产生过程中的发声努力。喉部运动皮层的功能磁共振成像激活和功能连接将确定核心边缘区域的数量。此外，还将对亚组的 sEMG 模式进行分类、比较，以及与神经 (fMRI)、心理生物学（皮质醇、人格）和声乐相关的总 sEMG 数据所有参与者和小组的功能（声学）数据。中心假设是喉部压力反应者增强了涉及边缘发声通路的边缘运动激活，这与喉外表面肌电活动的变化。总之，这个创新项目将决定神经、早期职业生涯中压力反应者和非反应者的心理生物学和声音功能特征声音疲劳和控制的教师。结果将为我们提供根本上缺失的数据了解压力在声音抱怨中的作用，并将产生关于声音抱怨的神经相关性的新见解 pMTD。该研究结果将对我们如何识别喉部反应者进行预防性治疗产生重大影响衡量并优化针对广泛行为声音和行为的干预措施的长期成功考虑神经康复干预（例如冥想和经颅疗法）的言语障碍磁刺激和可穿戴表面肌电技术。