Neurobiological and psychobiological signatures of vocal effort in early career teachers

早期职业教师发声努力的神经生物学和心理生物学特征

• 批准号: 10475746
• 负责人: MARIA DIETRICH
• 金额: $ 44.87万
• 依托单位: UNIVERSITY HOSPITAL BONN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475746
• 关键词: Acoustics; Address; Age; Algorithms; Amygdaloid structure; Anterior; Aphonia; Area; Behavioral; Behavioral inhibition; Brain; Case Study; Classification; Clinical; Conversion disorder; Cues; Data; Data Collection; Dysphonia; Educational process of instructing; Electrodes; Electromyography; Event; Exposure to; Fatigue; Female; Functional Magnetic Resonance Imaging; Functional disorder; Future Teacher; Goals; Hydrocortisone; Individual; Individual Differences; Intervention; Introversion; Knowledge; Laryngeal muscle structure; Larynx; Magnetic Resonance Imaging; Manuals; Meditation; Motor; Motor Cortex; Muscle; Muscle Tension; Neck; Neurobiology; Participant; Pathway interactions; Patient Self-Report; Patients; Pattern; Pattern Recognition; Peripheral; Personality; Persons; Play; Preventive measure; Production; Protocols documentation; Quality of life; Recurrence; Research; Risk; Role; Salivary; Sampling; Seeds; Skinfold Thickness; Speech; Speech Disorders; Stress; Subgroup; Sum; Surface; Technology; Transcranial magnetic stimulation; Treatment Efficacy; Voice; Voice Disorders; Voice Quality; acute stress; base; behavior measurement; behavioral response; career; clinically relevant; cohort; experimental study; improved; indexing; innovation; insight; interest; introvert; motor control; nervous system disorder; neural correlate; neurobiological mechanism; neurological rehabilitation; novel; programs; psychobiologic; relating to nervous system; social; stress reactivity; stressor; success; teacher; theories; trait; vocal cord; vocalization

Project Summary Muscle tension voice disorders such as primary muscle tension dysphonia (pMTD) are common and can profoundly impact quality of life. Precipitating events such as stress and introverted personality are possible factors in pMTD according to the trait theory of voice disorders. This theory proposed neurobiological mechanisms involving behavioral inhibition, but the condition remains an unclassified voice disorder with unknown causes. Large-scale research into the functional and clinical relevance of stressor-dependent limbic- motor interactions using functional MRI (fMRI) to support a neural basis for pMTD is missing. The aims of the project are to (1) determine the functional relevance of stressor-induced limbic activations on the control of voice in the brain in vocally healthy controls, (2) determine the clinical relevance of stressor-induced limbic activations on the control of voice in the brain in those with and without vocal fatigue, and (3) classify extralaryngeal muscular surface electromyography (sEMG) patterns of stress responders and nonresponders with and without vocal fatigue. Sixty female controls and thirty female early career teachers with vocal fatigue (based on Vocal Fatigue Index) between 21-39 years will read sentences with and without exposure to a speech anticipation stressor using a sparse-sampling event-related fMRI protocol. Salivary cortisol analyses will reveal cortisol stress responders and nonresponders. Participants will wear MRI-compatible sEMG electrodes on the anterior neck and complete a corresponding sEMG speech production protocol, but without stressor exposure, outside the scanner on a separate day. Audio data will be recorded to determine changes in vocal effort during speech production. fMRI activations in the laryngeal motor cortex and functional connectivity of core limbic regions will be determined. Further, sEMG patterns of subgroups will be classified, compared, and the total sEMG data correlated with neural (fMRI), psychobiological (cortisol, personality), and vocal function (acoustic) data for all participants and subgroups. The central hypothesis is that laryngeal stress responders have heightened limbic-motor activations involving the limbic vocalization pathway, which correlate with changes in extralaryngeal sEMG activity. In sum, this innovative project will determine neural, psychobiological, and vocal function signatures of stress responders and nonresponders in early career teachers with vocal fatigue and controls. The results will provide fundamentally missing data in our understanding of the role of stress in vocal complaints and will yield new insights about the neural correlates of pMTD. The study findings will have a significant impact on how we identify laryngoresponders for preventative measures and optimize the long-term success of interventions for a broad range of behavioral voice and speech disorders under consideration of neurorehabilitative interventions such as meditation and transcranial magnetic stimulation and wearable sEMG technology.

项目摘要 肌肉张力语音疾病，例如原发性肌肉张力烦躁不安（PMTD）很常见，可以 深刻影响生活质量。可能会导致压力和性格内向的人格之类的事件 根据语音障碍特征理论，PMTD中的因素。该理论提出了神经生物学 涉及行为抑制的机制，但这种病仍然是未分类的语音障碍 未知原因。关于压力依赖性边缘的功能和临床相关性的大规模研究 缺少使用功能性MRI（fMRI）支持PMTD神经基础的运动相互作用。目的 项目是（1）确定压力诱导的边缘激活对控制的功能相关性 （2）确定压力诱导的边缘的临床相关性 在患有和没有声带疲劳的人的大脑中控制声音的激活，以及（3）分类 应力反应者和无反应者的肌肉外肌肉表面肌电图（SEMG）模式 有和没有人声疲劳。六十名女性控制和三十名女性职业老师有声乐疲劳 （基于声带疲劳指数）21 - 39年之间，将阅读有没有接触的句子 使用稀疏采样事件相关的fMRI协议的语音预期应力源。唾液皮质醇分析 将揭示皮质醇应力反应者和无反应者。参与者将穿MRI兼容的SEMG 前颈上的电极并完成相应的SEMG语音生产协议，但没有 压力源暴露，在扫描仪外面的一天。将记录音频数据以确定 语音制作过程中的声音努力。喉运动皮层和功能连通性中的fMRI激活 将确定核心边缘区域的核心区域。此外，将将子组的SEMG模式分类，比较， SEMG数据与神经（fMRI），心理生物学（皮质醇，个性）和人声有关 所有参与者和亚组的功能（声学）数据。中心假设是喉应激 响应者提高了涉及边缘发声途径的边缘运动激活，该途径相关 随着咽喉外活性的变化。总而言之，这个创新的项目将决定神经， 早期职业生涯的压力反应者和无反应者的心理生物学和声带功能签名 有声乐疲劳和控制的老师。结果将在我们的我们的 了解压力在声音投诉中的作用，并将产生有关神经相关性的新见解 PMTD。研究结果将对我们识别喉为预防措施的喉部回应有重大影响 衡量并优化干预措施的长期成功，以广泛的行为语音和 正在考虑的语音障碍，包括冥想和颅内神经居住干预措施 磁刺激和可穿戴SEMG技术。