Mechanisms and Biomarkers of Environmental Stress

环境压力的机制和生物标志物

基本信息

批准号：
8785870
负责人：
Yinsheng Wang
金额：
$ 0.6万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8785870
关键词：
American Award Base Excision Repairs Biocompatible Materials Biological Markers Biology California Chemicals Chemistry DNA DNA Repair Pathway DNA lesion Development Disease Education Environmental Carcinogens Environmental Exposure Environmental Health Event Exposure to Feedback Fostering Funding Future Health Human Knowledge Learning Mission Monitor Nanotechnology National Institute of Environmental Health Sciences Oral Oxidative Stress Paper Participant Pharmaceutical Preparations Postdoctoral Fellow Process Proteins Request for Applications Research Research Personnel Role San Francisco Science Scientist Senior Scientist Societies Stress Students Toxic Environmental Substances Toxic effect Toxicology Training Travel Universities Work base environmental agent experience graduate student interdisciplinary approach lectures meetings nanotoxicology nucleobase oxidation posters professor programs public health relevance structural biology symposium

项目摘要

DESCRIPTION (provided by applicant) This application requests support for the program of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 248th National Meeting and Exposition in San Francisco, CA from August 10, 2014 to August 14, 2013. A unique feature of this ACS meeting is the broad theme of the national meeting, "Chemistry and Global Stewardship ", which aligns highlighted events across the meeting programs of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms contributing to disease processes and the toxicity of environmental agents, biomaterials, drugs and endogenous chemicals. The Division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. Three interrelated symposia are planned around the central theme "Mechanisms and Biomarkers of Environmental Stress" and include invited oral presentations delivered by a diverse group of leading established and emerging scientists. The three symposia for which support is requested have particularly strong relevance to the mission of the NIEHS. The first is entitled "Biomarkers for environmental exposure" and highlights the recent advances in the discovery of biomarkers for monitoring the exposure to various environmental toxicants. The second is entitled "Biomarkers of oxidative stress" and focuses on recent developments about the use of LC-MS/MS for monitoring the oxidation products of protein and DNA. The third symposium session is entitled "Mechanisms of base excision repair" and focuses on mechanisms of DNA base excision repair, a very important DNA repair pathway for removing many single-nucleobase DNA lesions induced by environmental carcinogens. A proffered paper session and a Young Investigators Symposium offer opportunities for young scientists in training to present their primary contributions and receive critical feedback from senior experts. Other highlights are a keynote lecture by Dr. Martyn Smith (University of California Berkeley) and two high-profile award symposia (the Founders Award and the Chemical Research in Toxicology Young Investigator Award). These sessions (supported by non-federal funds) will further enhance a strong overall program and provide diverse participants an outstanding representation of current work in the chemistry and biology of environmental exposure and disease.

描述（由申请人提供）本申请请求支持美国化学会 (ACS) 化学毒理学部于 2014 年 8 月 10 日至 2013 年 8 月 14 日在加利福尼亚州旧金山举行的第 248 届全国会议和博览会上的计划。该 ACS 的独特之处会议是全国会议“化学与全球管理”的广泛主题，它协调了 ACS 所有部门的会议计划中的重点活动。 ACS 化学毒理学部的使命是促进对导致疾病过程的化学机制以及环境因素、生物材料、药物和内源性化学物质的毒性的理解。该部门整合了化学、化学生物学、结构生物学、毒理学、环境健康科学和疾病机制方面的工作。围绕中心主题“环境压力的机制和生物标志物”计划举办三场相互关联的研讨会，其中包括由不同领域的知名和新兴科学家受邀进行口头报告。需要支持的三个研讨会与 NIEHS 的使命有着特别密切的相关性。第一篇题为“环境暴露的生物标志物”，重点介绍了用于监测各种环境毒物暴露的生物标志物发现的最新进展。第二篇题为“氧化应激的生物标志物”，重点介绍了使用 LC-MS/MS 监测蛋白质和 DNA 氧化产物的最新进展。第三场研讨会的主题是“碱基切除修复机制”，重点讨论DNA碱基切除修复机制，这是去除环境致癌物引起的许多单核碱基DNA损伤的非常重要的DNA修复途径。提供的论文会议和青年研究者研讨会为年轻科学家提供了接受培训的机会，以展示他们的主要贡献并获得资深专家的重要反馈。其他亮点包括 Martyn Smith 博士（加州大学伯克利分校）的主题演讲和两次备受瞩目的奖项研讨会（创始人奖和毒理学化学研究青年研究员奖）。这些会议（由非联邦基金支持）将进一步增强强大的整体计划，并为不同的参与者提供环境暴露和疾病的化学和生物学当前工作的杰出代表。