Antibodies for Characterizing the Structure and Function of Proteases

用于表征蛋白酶结构和功能的抗体

• 批准号: 8702411
• 负责人: Charles Scott Craik
• 金额: $ 34.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-24 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702411
• 关键词: Alzheimer' s Disease; Antibodies; Biology; Blood coagulation; Digestion; Functional disorder; Generations; Goals; Human; Malignant Neoplasms; Peptide Hydrolases; Physiological; Post-Translational Protein Processing; Proteome; Recombinant Antibody; Research; Structure; Technology; Therapeutic; human disease; tool

Significance: Proteases make up 2% of the human proteome (3), and their functional activity is a unique, irreversible post-translational modification of their target substrates (7). Proteases are involved in a number of important physiological functions from blood coagulation to digestion and pathophysiological activities necessary for activation and propagation of cancer cascades and Alzheimer's disease (8). More information about protease biology and pathophysiology in addition to new selective therapeutics would be important for understanding and treating human disease.

意义： 蛋白酶占 2% 人类蛋白质组 (3)，其功能活性是对其目标底物进行独特的、不可逆的翻译后修饰 (7)。蛋白酶参与许多重要的生理功能，从凝血到消化，以及癌症级联和阿尔茨海默病的激活和传播所必需的病理生理活动 (8)。除了新的选择性疗法之外，有关蛋白酶生物学和病理生理学的更多信息对于理解和治疗人类疾病也很重要。