Administrative, Education, and Analytic Support Core

行政、教育和分析支持核心

• 批准号: 10685508
• 负责人: MATTHEW S FREIBERG
• 金额: $ 14.1万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685508
• 关键词: Address; Advisory Committees; Aging; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Area; Bile Acids; Biological Markers; Biological Specimen Banks; Biometry; Blood; Boston; Budgets; Cardiovascular Diseases; Cause of Death; Cessation of life; Clinical Trials Data Monitoring Committees; Cohort Studies; Collaborations; Data; Disease; Education; Event; Fostering; Funding; Future; Goals; Grant; HIV; HIV Infections; HIV/AIDS; Heart; Inflammation; Infrastructure; Intervention; Laboratories; Lead; Leadership; Lung; Mentored Clinical Scientist Development Program; Mentorship; Metabolic Pathway; Metagenomics; Monitor; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Persons; Policies; Population; Preparation; Probiotics; Procedures; Program Research Project Grants; Progress Reports; Protocols documentation; Publications; Randomized, Controlled Trials; Research; Research Personnel; Resources; Risk Factors; Russia; Services; Site; Sleep; Specimen; Teacher Professional Development; Testing; Training; Training Programs; Translational Research; Uganda; United States National Institutes of Health; Universities; University resources; Veterans; Volatile Fatty Acids; Work; Zinc; alcohol research; biobank; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular risk factor; cohort; data repository; disorder risk; dysbiosis; epidemiology study; experience; follow-up; gastrointestinal; gut dysbiosis; gut microbiome; high risk; improved; interest; meetings; metabolomics; microbial; microbiome; microbiome research; modifiable risk; mortality risk; multidisciplinary; nutrition; program dissemination; programs; recruit; synergism; trial design; trimethyloxamine

Alcohol consumption is an important modifiable cardiovascular disease (CVD) risk factor among people living with HIV infection (PLWH). Given that alcohol use is common among PLWH, and CVD is a leading non-AIDS disease and cause of death among PLWH, addressing alcohol consumption in this population is critically important. The Microbiome, mETabolites, and Alcohol in HIV to reduce CVD Program Project Grant (PPG) is a multidisciplinary group of investigators with expertise in alcohol, HIV, gut microbiome, biomarker research, nutrition, and randomized controlled trial (RCT) design. Our overarching hypothesis for this P01 application is that among PLWH, a probiotic can mitigate alcohol associated dysbiosis and lower levels of microbial translocation, inflammation, and improve metabolite profiles (Project 1); and that harmful levels of these metabolites are associated with higher risk of CVD and death events (Project 2). To test this hypothesis, this PPG will leverage the Veterans Aging Cohort Study, the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS, the Integrated Metagenomic and Metabolomic Core (IMMC) at the University of Louisville Alcohol Research Center, and the Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch NIH K12 junior faculty training program to accomplish these objectives: (1) To determine if a probiotic tailored for alcohol associated gut dysbiosis mitigates this dysbiosis, microbial translocation, inflammation, harmful metabolites, CVD and mortality risk (Project 1 RCT, Lead Freiberg); (2) To assess the association between alcohol use, CVD and death via three metabolic pathways among PLWH (Project 2 Cohort, Lead So-Armah); (3) To provide metabolomic and biomarker laboratory resources (IMMC, Lead Barve); (4) Administrative leadership and services to support the proposed research (Admin Core, Leads Freiberg and Barve); and (5) Encourage and develop future trainees. The Administrative (Admin) Core will be responsible for day-to-day management and functioning of the PPG. The Admin Core goal is to ensure that the scientific and programmatic activities of the PPG are conducted per protocol in a timely fashion, within budget, and with the highest quality. The Admin Core has these specific aims: (1) To provide administrative oversight of the PPG, including assembling a steering committee, program advisory committee, and data safety monitoring board, and developing the policies and procedures necessary to successfully organize and complete our specific aims and training initiatives; (2) To provide services to PPG investigators and trainees (e.g., study progress reports, compliance assurance, assistance with presentations and publications), and to promote/disseminate the PPG'S work; (3) To provide resources (e.g., data and specimens), biostatistical support, and mentorship to new investigators ; (4) To promote synergy within and across other funded PPGs; (5) To monitor progress and compliance of the PPG's components, implement improvement mechanisms if necessary, and assist investigators with challenges (e.g., recruitment).

饮酒是生活人员中重要的可修改心血管疾病（CVD）风险因素 艾滋病毒感染（PLWH）。鉴于酒精使用在PLWH中很常见，而CVD是领先的非AID PLWH中的疾病和死亡原因，解决该人群中的饮酒量很严重 重要的。艾滋病毒中的微生物组，代谢产物和酒精以减少CVD计划项目赠款（PPG）是 具有饮酒专业知识的多学科研究人员，艾滋病毒，肠道微生物组，生物标志物研究， 营养和随机对照试验（RCT）设计。我们针对此P01应用的总体假设 是在PLWH中，益生菌可以减轻与酒精相关的营养不良和微生物水平较低的水平 易位，炎症和改善代谢物谱（项目1）；这些有害的水平 代谢物与CVD和死亡事件的较高风险有关（项目2）。为了检验这一假设， PPG将利用退伍军人衰老队列研究，乌干达俄罗斯波士顿酒精网络 艾滋病毒/艾滋病的研究合作，综合的宏基因组和代谢组核心（IMMC） 路易斯维尔大学酒精研究中心，艾滋病毒和心脏，肺，血液，血液， 和睡眠研究NIH K12初级教师培训计划，以实现这些目标：（1）确定 如果针对酒精相关的肠道营养不良的益生菌减轻了这种营养不良，微生物易位， 炎症，有害代谢产物，CVD和死亡率风险（项目1 RCT，Lead Freiberg）； （2）评估 通过PLWH之间的三个代谢途径，酒精使用，CVD和死亡之间的关联（项目2 队列，铅so-armah）； （3）提供代谢组和生物标志物实验室资源（IMMC，Lead barve）; （4）支持拟议研究的行政领导和服务（管理员核心，潜在客户 Freiberg和Barve）； （5）鼓励和发展未来的学员。行政（管理）核心将是 负责PPG的日常管理和功能。管理员核心目标是确保 PPG的科学和程序性活动是按照及时进行的， 预算，质量最高。管理员核心具有以下特定目的：（1）提供管理 对PPG的监督，包括组建指导委员会，计划咨询委员会和数据 安全监控委员会，制定成功组织和组织所必需的政策和程序 完成我们的具体目标和培训计划； （2）为PPG调查人员和受训者提供服务 （例如，研究进度报告，合规性保证，在演讲和出版物方面的协助）以及 促进/传播PPG的工作； （3）提供资源（例如数据和标本），生物统计学 支持新调查人员的支持和指导； （4）在其他资助的PPG中促进协同作用； （5）监视PPG组件的进度和遵守情况，请执行改进机制 必要的，并协助调查人员应对挑战（例如招聘）。