Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch (V-SCHoLARS, K12)

范德比尔特艾滋病毒与心脏、肺、血液和睡眠研究学者（V-SCHoLARS，K12）

• 批准号: 9761561
• 负责人: MATTHEW S FREIBERG
• 金额: $ 40.03万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761561
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Aging; Basic Science; Bioinformatics; Biometry; Blood; Cardiopulmonary; Cardiovascular system; Clinical; Clinical Research; Cohort Studies; Communicable Diseases; Comorbidity; Data; Development Plans; Doctor of Philosophy; Educational workshop; Environment; Epidemiology; Extramural Activities; Faculty; Fellowship; Funding; Goals; Grant; HIV; HIV Infections; Health Sciences; Health Services; Heart; Hematology; Institutes; Libraries; Link; Location; Lung; Master of Science; Medicine; Mentored Clinical Scientist Development Program; Mentors; Population; Population Study; Program Development; Pulmonary Heart Disease; Recording of previous events; Research; Research Design; Research Personnel; Research Project Grants; Resource Development; Resources; SECTM1 gene; Scientist; Sleep; Societies; Southeastern United States; Talents; Tennessee; Time; Training; Translational Research; United States National Institutes of Health; Universities; Veterans; antiretroviral therapy; biobank; career; career development; clinical investigation; cohort; didactic education; medical schools; next generation; programs; recruit; success; translational clinical trial

With effective combination antiretroviral therapy (ART), people living with HIV/AIDS are living longer, but this success is tempered by rising rates of cardiopulmonary, hematologic, and sleep (HLBS) comorbidities in the HIV population. Vanderbilt University’s location in the Southeastern United States places it in the region with the highest rates incident HIV infection and cardiopulmonary disease. For these reasons, this application seeks to establish the Vanderbilt SCholars in HIV and Heart, Lung, Blood, And Sleep ReSearch (V-SCHoLARS, K12) program to train and mentor the next generation of HIV HLBS researchers with expertise in domains ranging from basic science to large population studies. We propose to support 5 junior faculty V-SCHoLARS who have completed an MD or PhD in the health sciences at a level of 75% effort for 2 years. Vanderbilt has a rich research environment and highly successful history of developing the careers of research scientists. Vanderbilt scholars in career development programs have an 84% success rate for extramural funding and a 70% K to R or R-equivalent conversion rate. Our proposed program, aided by Vanderbilt’s Office for Diversity Affairs, will recruit from a diverse pool of talented applicants through Vanderbilt's existing T32 grants; clinical/research fellowships in cardiovascular, pulmonary, hematology, and sleep medicine; the VA Quality Scholars Fellowship; and Meharry Medical College. Scholars will have access to 33 established NIH-funded mentors with expertise in HIV/infectious disease, cardiovascular, pulmonary, hematology, or sleep medicine who have a demonstrated track record of mentoring early career scholars, as well as 14 topic experts in the fields of basic science, clinical trials/translational research, population/epidemiology, health services/operational research, and biostatistics and bioinformatics. The program will have 4 major components: (1) formal mentoring (each scholar will have a paired HIV and an HLBS mentor), 2) didactic education that includes an opportunity to obtain a Master of Science in Clinical Investigation, 3) guaranteed protected time, and 4) a mentored research project that will be submitted as part of career development grant in year two. Each Scholar will have an individualized development plan with milestones tailored to their scientific background, training needs, and career goals. Scholars will have access to institutional resources including the Vanderbilt Institute for Clinical and Translational Research, the Tennessee Center for AIDS Research, existing cohort data (e.g., Veterans Aging Cohort Study), biostatistical support, 50 research cores, and BioVu, one of the world’s largest clinically linked biobanks. Scholars will also be supported by a range of career development resources: interdisciplinary expert consultant studios to vet scientific ideas, aims, and research designs; a K08/K23/R01 funded grant library; grant workshops; work-in-progress sessions; and research seminars through the Newman Society, a professional group for all career development awardees at Vanderbilt. Taken together, Vanderbilt provides an optimal environment for developing a diverse, well-trained next generation of HIV HLBS researchers.

凭借有效的组合抗逆转录病毒疗法（ART），艾滋病毒/艾滋病的人的寿命更长，但这是 在心肺，血液学和睡眠（HLBS）合并症的速度上升的速度上升的温度 艾滋病毒人群。范德比尔特大学（Vanderbilt University）在美国东南部的位置将其置于该地区 艾滋病毒感染和心肺疾病的最高发生率。由于这些原因，该应用程序寻求 在艾滋病毒和心脏，肺，血液和睡眠研究中建立范德比尔特学者（V-Scholars，K12） 培训和指导下一代HIV HLB研究人员具有专业知识的计划 从基础科学到大型人口研究。我们建议支持5名有 在健康科学中完成了MD或博士学位，以75％的努力持续了2年。范德比尔特有钱 研究环境和发展研究科学家的职业的非常成功的历史。范德比尔特 职业发展计划中的学者的校外资金成功率为84％，R对于R的k级为70％ 或r等效转换率。我们的拟议计划在范德比尔特多元化事务办公室的帮助下，将 通过范德比尔特现有的T32赠款从潜水员的才华横溢的应用程序中招募；临床/研究 心血管，肺部，血液学和睡眠药物的奖学金； VA质量学者 奖学金;和梅哈里医学院。学者将可以使用33个已建立的NIH资助的导师 具有艾滋病毒/传染病，心血管，肺部，血液学或睡眠药物方面的专业知识 展示了早期职业学者的心理记录，以及基本领域的14个主题专家 科学，临床试验/转化研究，人口/流行病学，卫生服务/运营研究， 以及生物统计学和生物信息学。该计划将有4个主要组成部分：（1）正式心理（每个） 学者将有配对的艾滋病毒和HLB的心理），2）教育教育，其中包括一个机会 获得临床研究的科学硕士，3）保证的受保护时间，4）重要的研究 第二年将作为职业发展赠款的一部分提交的项目。每个学者都会有一个 个性化的发展计划，其里程碑是针对其科学背景，培训需求和 职业目标。学者将可以使用包括范德比尔特临床研究所在内的机构资源 和翻译研究，田纳西州艾滋病研究中心，现有同类数据（例如，退伍军人 衰老队列研究），生物统计学支持，50个研究核心和BIOVU是世界上临床上最大的临床之一 链接的生物库。学者还将得到一系列职业发展资源的支持：跨学科 专家顾问工作室审查科学思想，目标和研究设计； K08/K23/R01资助的赠款 图书馆;授予研讨会；进行工作的会议；以及通过纽曼学会（Newman Society）进行的研究下水道 范德比尔特所有职业发展奖的专业小组。两者一起，范德比尔特提供了 发展多样性，训练有素的下一代HIV HLBS研究人员的最佳环境。