AIDS and Aging Research Platform (AARP)

艾滋病和老龄化研究平台 (AARP)

• 批准号: 10683071
• 负责人: STEVEN N. AUSTAD
• 金额: $ 76.99万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683071
• 关键词: Acceleration; Acquired Immunodeficiency Syndrome; Address; Age; Age-associated memory impairment; Aging; American; Area; Behavioral Research; Biology of Aging; Brain; Capsicum; Cardiovascular Diseases; Caring; Cessation of life; Chronic Disease; Clinic; Clinical; Data; Development; Diabetes Mellitus; Education; Elderly; Equipment and supply inventories; Future; Geriatrics; Gerontology; Geroscience; Goals; HIV; Hearing; Hospitalization; Impaired cognition; Individual; Infrastructure; Intervention; Investigation; Kidney Diseases; Link; Liver diseases; Longevity; Malignant Neoplasms; Mentors; Metabolic syndrome; Modeling; Molecular; Neurocognition; Outcomes Research; Persons; Phenotype; Physical Function; Pilot Projects; Prevention; R24; Research; Research Personnel; Resources; Science; Sensory; Shock; Site; Stroke; Syndrome; System; Testing; Time; Training; United States National Institutes of Health; Vision; Work; antiretroviral therapy; clinical care; clinical phenotype; clinical research site; cognitive testing; comorbidity; data integration; disability; exercise program; experience; falls; frailty; functional decline; functional disability; healthspan; human old age (65+); improved; insight; interdisciplinary collaboration; meetings; middle age; mortality; multiple chronic conditions; programs; response; small molecule; social; success; tool

ABSTRACT Effective antiretroviral therapy (ART) for people living with HIV (PLWH) has dramatically reduced mortality resulting in many surviving into middle and old age. Despite this success, PLWH experience high rates of comorbidities, multimorbidity (>1 major chronic illness), and functional decline at ages 10-15 years younger than uninfected controls. Geriatric syndromes, such as frailty and falls, are becoming more prevalent in PLWH. Thus, there is an urgent need to focus on the healthspan of PLWH rather than just mortality. Healthspan, in contrast to lifespan, is defined as the time someone is healthy not just alive. The Claude D. Pepper Older American Independence Centers (OAlCs) were established to help define aging phenotypes and advance research into the causes, prevention and treatment of functional decline with age. OAlCs have developed and validated functional assessments in aging, but lack depth and breadth of HIV expertise. In contrast, Centers for AIDS Research (CFARs) have unparalleled expertise in HIV-related basic, clinical and social/behavioral research, but lack robust resources and expertise in aging biology, geriatric clinical phenotypes and functional assessments. Our R24 project, “Developing Research At The Interface Of HIV And Aging” was in response to PA-12-064 "Network and Infrastructure Support for Development of Interdisciplinary Aging Research." Through this R24 we successfully linked CFARs and OAICs to support pilot projects in high-priority focus areas and mentor researchers at the interface of HIV and Aging. Our vision for this proposal is to build on this success deepening the ongoing linkage of CFARs and OAICs and expanding the network to include Nathan Shock Centers of Excellence in the Basic Biology of Aging (NSCs) and the McKnight Brain Institutes (MBIs). By bringing together OAICs expertise on functional decline in aging, with NSC expertise in aging biology and the mechanisms underlying function decline, with MBI expertise on age-related cognitive decline, and CFAR expertise on HIV, we create an integrated approach to advancing and accelerating investigation at the interface of HIV and aging via the following Aims: Aim 1. Provide specific training models and a brief inventory of tools to efficiently collect data to improve HIV clinical care and outcomes research. Aim 2. Using a geroscience approach, provide a platform for pilot studies to determine the links between molecular hallmarks of aging with functional decline, and the development of common comorbidities among aging PLWH. Aim 3. Develop infrastructure for evaluating interventional approaches and their application to HIV care. Aim 4. Provide educational support, implementation advice and mentoring for emerging investigators to establish/advance research programs in HIV and aging. These synergistic aims leverage and expand the infrastructure and close ties built in the R24 of HIV expertise from CFARs with the gerontology and functional assessment expertise within the OAlCs and expand them with inclusion of NSCs and MBIs to enhance and accelerate investigation at the interface of HIV and aging.

抽象的 艾滋病毒（PLWH）患者的有效抗逆转录病毒疗法（ART）大大降低了死亡率 导致许多生存到中年和老年。尽管取得了成功，但PLWH的速度很高 合并症，多种疾病（> 1个重大慢性病）和年龄较小的10-15岁的功能下降 比未感染的对照。老年综合症，例如脆弱和瀑布，在PLWH中变得越来越普遍。 这是迫切需要关注PLWH的健康状况，而不仅仅是死亡率。 HealthSpan，IN 与寿命形成鲜明对比的是，定义为某人健康的时候，不仅是活着的时候。 Claude D. Pepper年龄较大 建立了美国独立中心（OALC），以帮助定义衰老表型并提高 研究原因，预防和治疗功能下降随着年龄的增长。 Oalcs已经发展了， 验证了衰老的功能评估，但缺乏艾滋病毒专业知识的深度和广度。相反，中心 艾滋病研究（CFARS）在与HIV相关的基本，临床和社会/行为方面具有无与伦比的专业知识 研究，但缺乏强大的资源和老化生物学，老年临床表型和功能的专家 评估。我们的R24项目“在艾滋病毒和衰老的界面开发研究”是为了回应 PA-12-064“网络和基础设施支持跨学科衰老研究的发展。”通过 这是R24，我们成功地将CFAR和OAICS联系起来，以支持高优先级重点领域的试点项目， 艾滋病毒和衰老界面的导师研究人员。我们对该建议的愿景是建立在这一成功的基础上 加深CFAR和OAICS的持续联系，并扩大网络以包括Nathan Shock 卓越的老化生物学（NSC）和McKnight Brain Institutes（MBIS）的卓越中心。经过 将衰老功能下降的OAICS专业知识融合在一起，以及NSC生物学方面的NSC专业知识和 功能下降的机制下降，具有与年龄相关的认知能力下降的MBI专业知识，并且CFAR 艾滋病毒的专业知识，我们创建了一种综合方法来推进和加速调查 艾滋病毒和衰老的界面通过以下目的： 目标1。提供特定的培训模型和简短的工具清单，以有效收集数据以改善艾滋病毒 临床护理和结果研究。目标2。使用Geroscience方法，为试点研究提供平台 确定衰老标志与功能决策之间的联系，以及 老化的PLWH中的常见合并症。目标3。开发用于评估介入的基础设施 方法及其在艾滋病毒护理中的应用。目标4。提供教育支持，实施建议和 指导新兴的研究人员在艾滋病毒和衰老中建立/提高研究计划。 这些协同的旨在利用和扩大艾滋病毒专业知识R24建立的基础设施和紧密联系 来自OALC中具有老年病和功能评估专业知识的CFAR，并通过 包括NSC和MBI，以增强和加速艾滋病毒和衰老界面的投资。

项目成果

Evaluating the Sick Quitting Hypothesis for Frailty Status and Reducing Alcohol Use Among People With HIV in a Longitudinal Clinical Cohort Study.

在一项纵向临床队列研究中评估艾滋病毒感染者虚弱状态的病戒假说和减少饮酒。

• DOI: 10.1097/jnc.0000000000000445
• 发表时间: 2024
• 期刊: The Journal of the Association of Nurses in AIDS Care : JANAC
• 作者: Ruderman,StephanieA;Drumright,LydiaN;Delaney,JosephAC;Webel,AllisonR;Fitzpatrick,AnnetteL;Whitney,BridgetM;Nance,RobinM;Hahn,AndrewW;Ma,Jimmy;Mixson,L.Sarah;Eltonsy,Sherif;Willig,AmandaL;Mayer,KennethH;Napravnik,Sonia
• 通讯作者: Napravnik,Sonia

Growing older with HIV in the Treat-All Era.

• DOI: 10.1002/jia2.25997
• 发表时间: 2022-09
• 期刊: Journal of the International AIDS Society
• 影响因子: 6

Validity Properties of a Self-reported Modified Frailty Phenotype Among People With HIV in Clinical Care in the United States.

• DOI: 10.1097/jnc.0000000000000389
• 发表时间: 2023-03-01
• 期刊: JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
• 影响因子: 2
• 作者: Ruderman, Stephanie A.;Webel, Allison R.;Willig, Amanda L.;Drumright, Lydia N.;Fitzpatrick, Annette L.;Odden, Michelle C.;Cleveland, John D.;Burkholder, Greer;Davey, Christine H.;Fleming, Julia;Buford, Thomas W.;Jones, Raymond;Nance, Robin M.;Whitney, Bridget M.;Mixson, L. Sarah;Hahn, Andrew W.;Mayer, Kenneth H.;Greene, Meredith;Saag, Michael S.;Kamen, Charles;Pandya, Chintan;Lober, William B.;Kitahata, Mari M.;Crane, Paul K.;Crane, Heidi M.;Delaney, Joseph A. C.
• 通讯作者: Delaney, Joseph A. C.

Tobacco Smoking and Pack-Years Are Associated With Frailty Among People With HIV.

吸烟和吸烟年数与艾滋病毒感染者的虚弱有关。

• DOI: 10.1097/qai.0000000000003242
• 发表时间: 2023
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Ruderman,StephanieA;Odden,MichelleC;Webel,AllisonR;Fitzpatrick,AnnetteL;Crane,PaulK;Nance,RobinM;Drumright,LydiaN;Whitney,BridgetM;Mixson,LyndseySarah;Ma,Jimmy;Willig,AmandaL;Haidar,Lara;Eltonsy,Sherif;Mayer,KennethH