Mechanisms and Barriers in Nanomedicine-2023

纳米医学的机制和障碍-2023

• 批准号: 10683553
• 负责人: THOMAS ANCHORDOQUY
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683553
• 关键词: Artificial nanoparticles; Award; Biochemical; Biological; Blood Vessels; Categories; Cellular biology; Clinical; Clinical Trials; Colorado; Disabled Persons; Disease model; Disparity population; Drug Delivery Systems; Education; Educational workshop; Ethnic Population; Event; Funding; Goals; Grant; Image; Immune; Immunologics; Immunology; Industrialization; International; Learning; Malignant Neoplasms; Minority Groups; Modeling; Nanotechnology; Pathology; Performance; Postdoctoral Fellow; Pre-Clinical Model; Process; Proteins; Research; Research Personnel; Role; Scientist; Senior Scientist; Students; System; Systems Biology; Translations; Travel; Underrepresented Populations; Update; Visit; Woman; cancer therapy; design; disadvantaged background; graduate student; in vivo; innovation; nano; nanodrug; nanomaterials; nanomedicine; nanoparticle delivery; nanotoxicity; novel strategies; particle; programs; racial population; senior faculty; symposium; translational model; tumor

In the recent years, remarkable progress has been made in the synthesis and characterization of engineered nanoparticles for imaging and treatment of cancers, resulting in several promising candidates in clinical trials. However, the nano drug delivery field needs a better understanding of biological and immunological barriers, cancer pathology and immunology, and appropriate and relevant models of disease. There is a growing sentiment in the field that there is need to revisit the basics and to better understand the integrated biological, pathophysiological and immunological processes for effective translation to nanomedicine design and performance. We propose to organize a conference- workshop “Mechanisms and Barriers in Nanomedicine” in Golden, Colorado in May 2023. The program will be focused on the following aspects: a) interactions at the particle interface; b) immune recognition and toxicity of nanomaterials; c) relevance of models; d) in vivo barriers; d) new targets; d) regulatory/industrial hurdles to translation. Leading experts will discuss the integrated roles of systems immunology, protein corona, and tumor and vascular cell biology that modulate nanomedicine retention and functionality in tumors. We strive to achieve the following goals: a) to provide an educational, yet critical, forum into integrated biochemical and biological barriers controlling nanoparticle delivery and their functionality; b) to present an update and potential paradigm shift on the strategies to mitigating these problems; c) by conducting open, unrestricted, non-proprietary discussion among senior faculty, young investigators and graduate students, we hope to trigger new ideas and concepts that will move the field forward. The main innovation of the conference-workshop is in providing an open forum for discussing problems with drug delivery and in the focus on biological, immunological and translational aspects of nanotechnology. The R13 grant will be used to help with conference attendance for students and postdocs, including underrepresented, racial and ethnic groups, individuals with disabilities, individuals from disadvantaged backgrounds, and women.

近年来，在综合和表征中取得了显着进步 用于成像和治疗癌症的工程纳米颗粒，产生了几种诺言 临床试验中的候选人。但是，纳米药物输送领域需要更好地了解 生物学和免疫障碍，癌症病理学和免疫学，以及适当且相关的 疾病模型。该领域的情绪越来越多，需要重新审视基础知识和 更好地了解综合的生物学，病理生理和免疫学过程 有效翻译为纳米医学设计和性能。我们建议组织一次会议 - 2023年5月，科罗拉多州戈尔登市的“纳米医学机构和障碍”研讨会。该计划 将集中在以下方面：a）粒子界面处的相互作用； b）免疫识别 和纳米材料的毒性； c）模型的相关性； d）体内屏障； d）新目标； d） 翻译的监管/工业障碍。领先的专家将讨论系统的综合作用 免疫学，蛋白质电晕以及肿瘤和血管细胞生物学，调节纳米医学保留率 和肿瘤的功能。我们努力实现以下目标：a）提供一个教育，但 关键的，论坛纳入纳米颗粒传递和 它们的功能； b）提出更新和潜在的范式减轻策略 这些问题； c）通过对高级教师进行公开，不受限制的非专有讨论， 年轻的调查人员和研究生，我们希望触发将会移动的新想法和概念 领域向前。会议工厂的主要创新是为 讨论药物输送问题以及关注生物学，免疫和转化的问题 纳米技术的各个方面。 R13赠款将用于帮助学生参加会议 以及包括人数不足，种族和族裔的博士后，患有疾病的人， 来自处境不利的背景和妇女的个人。