CORE CENTER FOR CLINICAL RESEACH IN TOTAL JOINT ARTHROPLASTY (CORE-TJA)

全关节置换术临床研究核心中心 (CORE-TJA)

基本信息

批准号：
10703439
负责人：
Daniel Berry
金额：
$ 62.94万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-16 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10703439
关键词：
Acceleration Address Adopted Adoption Advisory Committees American Area Berry Big Data Biometry Caring Characteristics Clinic Clinical Clinical Data Clinical Research Clinical Sciences Collaborations Communication Communities Consultations Data Data Analyses Data Collection Data Element Data Sources Databases Development Disease Documentation Education Electronic Health Record Ensure Environment Epidemiology Evaluation Future Goals Health Services Research Hip Prosthesis Implant Informatics Information Technology Infrastructure Institution Intervention Intervention Studies Joint Prosthesis Knee Prosthesis Leadership Link Medical Informatics Methodology Modeling Musculoskeletal Natural Language Processing Observational Study Operative Surgical Procedures Outcome Patient Care Patients Policies Positioning Attribute Procedures Productivity Registries Replacement Arthroplasty Research Research Methodology Research Personnel Resources Secure Services Surgeon Technology Time Training Translating Translational Research Translations United States Vision analytical method clinical center cost data registry data resource education resources evidence base experience flexibility improved improved outcome innovation next generation novel outreach programs response skills tool willingness

项目摘要

ABSTRACT - OVERALL Total joint arthroplasty (TJA) is the most common and fastest growing surgery in the nation. There are currently more than 7 million Americans living with artificial joints. Despite the high surgery volume, the evidence base for TJA procedures, technologies and associated interventions are limited. Many surgical approaches and implant technologies in TJA are adopted based on theoretical grounds with limited clinical evidence. The wider TJA research community needs access to large, high quality and rich data sources and state-of-the-art clinical research standards and information technologies to overcome methodological and practical challenges in studies of surgical and nonsurgical interventions in TJA. The overarching goal of Mayo Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) is to facilitate innovative, methodologically rigorous and interdisciplinary clinical research that will directly improve TJA care and the outcomes. The CORE-TJA will serve as a disease (TJA) and theme-focused Center providing shared methodological expertise, education and data resources. The CORE-TJA will leverage big data resources for TJA research, provide customized methodology resources in epidemiology, biostatistics, health services research and medical informatics, and establish synergistic interactions around an integrated Core (American Joint Replacement Registry – AJRR). The Specific Aims of CORE-TJA are: (1) To provide administrative and scientific oversight of CORE-TJA activities (Administrative Core), (2) To provide integrated services, access to large databases and novel analytical methods for clinical research in TJA (Methodology Core); and (3) To meet the unique data needs of the TJA research community and to strengthen the national capacity for large-scale observational and interventional studies in TJA using national registry data (Resource Core). The CORE-TJA will be integrated within the long-standing and highly centralized clinical research environment of the Mayo Clinic, thereby leveraging existing expertise and infrastructure resources, including the Center for Clinical and Translational Science. All CORE-TJA activities will be evaluated using robust metrics to ensure continuous evaluation, flexibility and improvement in response to the most pressing needs of the TJA research community.

摘要 - 总体全关节置换术（TJA）是美国最常见且发展最快的手术。目前有超过 700 万美国人使用人工关节，尽管手术量很大，但 TJA 手术、技术和相关干预措施的证据基础有限。 TJA 中的方法和种植技术都是基于理论依据而采用的，临床有限更广泛的 TJA 研究界需要获得大量、高质量和丰富的数据源和证据。最先进的临床研究标准和信息技术，以克服方法论和 TJA 手术和非手术干预研究的实际挑战 Mayo 的总体目标。全关节置换术临床研究核心中心 (CORE-TJA) 旨在促进创新、严格的方法论和跨学科临床研究将直接改善 TJA 护理和 CORE-TJA 将作为一个疾病 (TJA) 和主题中心，提供共享的成果。 CORE-TJA 将利用大数据资源来实现方法论专业知识、教育和数据资源。 TJA研究，提供流行病学、生物统计学、健康服务等定制方法学资源研究和医学信息学，并围绕综合核心（美国关节置换登记处 – AJRR）。 CORE-TJA 的具体目标是： (1) 为 CORE-TJA 提供行政和科学监督活动（管理核心），(2) 提供综合服务、访问大型数据库和新颖的 TJA（方法学核心）中临床研究的分析方法；以及（3）满足独特的数据需求 TJA 研究界并加强国家大规模观测和使用国家注册数据（核心资源）进行的 TJA 干预研究将被整合。在梅奥诊所长期且高度集中的临床研究环境中，从而利用现有的专业知识和基础设施资源，包括临床和转化中心科学。所有 CORE-TJA 活动都将使用稳健的指标进行评估，以确保持续评估，灵活性和改进，以满足 TJA 研究界最紧迫的需求。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Primary and Revision Total Knee Arthroplasty in Patients With Pulmonary Hypertension: High Perioperative Mortality and Complications.

DOI：
10.1016/j.arth.2021.07.005
发表时间：
2021-11
期刊：
JOURNAL OF ARTHROPLASTY
影响因子：
3.5
作者：
Baker, Courtney E.;Chalmers, Brian P.;Taunton, Michael J.;Kremers, Hilal Maradit;Amundson, Adam W.;Berry, Daniel J.;Abdel, Matthew P.
通讯作者：
Abdel, Matthew P.

Nuts and Bolts of Patient-Reported Outcomes in Orthopaedics.

骨科患者报告结果的具体细节。

DOI：
10.1016/j.arth.2022.11.011
发表时间：
2023
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Lee,MinjiK;Zaniletti,Isabella;Larson,DirkR;Lewallen,DavidG;Berry,DanielJ;MaraditKremers,Hilal
通讯作者：
MaraditKremers,Hilal

Demystifying Statistics and Machine Learning in Analysis of Structured Tabular Data.

揭秘结构化表格数据分析中的统计和机器学习。

DOI：
10.1016/j.arth.2023.08.045
发表时间：
2023
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Khosravi,Bardia;Weston,AlexanderD;Nugen,Fred;Mickley,JohnP;MaraditKremers,Hilal;Wyles,CodyC;Carter,RickeyE;Taunton,MichaelJ
通讯作者：
Taunton,MichaelJ

Immortal Time Bias in the Analysis of Time-to-Event Data in Orthopedics.

DOI：
10.1016/j.arth.2021.06.012
发表时间：
2021-10
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Larson DR;Crowson CS;Devick KL;Lewallen DG;Berry DJ;Maradit Kremers H
通讯作者：
Maradit Kremers H

Adjusted Survival Curves Improve Understanding of Multivariable Cox Model Results.

DOI：
10.1016/j.arth.2021.06.002
发表时间：
2021-10
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Lundgreen CS;Larson DR;Atkinson EJ;Devick KL;Lewallen DG;Berry DJ;Maradit Kremers H;Crowson CS
通讯作者：
Crowson CS