OSUCCC CUSP2CT

基本信息

批准号：
10701884
负责人：
CHERYL T. LEE
金额：
$ 69.46万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-12 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701884
关键词：
Address African American Agreement Area Black race Breast Cancer Center Cancer Patient Cancer health equity Catchment Area Centers for Population Health Chest Clinic Clinical Cancer Center Clinical Trials Communities Community Clinical Oncology Program Community Health Aides Community Hospitals Community Outreach Community Practice Comprehensive Cancer Center County Detection Disease Disparity Education Eligibility Determination Enrollment Ethnic Population Fostering Genitourinary system Goals Health system Healthcare Systems Hematology Hispanic Hospitals Institution Intervention Intervention Trial Left Malignant Neoplasms Methods Minority Modality Modeling National Clinical Trials Network Ohio Outcome Patients Pattern Persons Phase Population Population Group Prevention trial Process Provider Public Health Research Resources Risk Site System Theoretical model Therapeutic Intervention Underrepresented Populations Universities Work bilingualism biomedical referral center black patient cancer health disparity cancer prevention cancer referral center clinical practice clinical trial protocol community partnership control trial design disparity gap ethnic minority experience gastrointestinal health disparity improved member minority communities outreach participant enrollment patient navigator primary outcome programs racial minority racial minority population racial population secondary outcome success treatment trial

项目摘要

PROJECT SUMMARY The overall goal of The Ohio State University (OSU) Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) is to increase the referral and accrual of racial/ethnic minorities to NCI's National Clinical Trials Network (NCTN) prevention/control and treatment trials at the OSU Comprehensive Cancer Center (OSUCCC). This research is grounded in the socioecologic model developed by the Centers for Population Health and Health Disparities (Warnecke, et al. Am J Public Health 2008) and utilizes the theoretical model, Accrual to Clinical Trials (Paskett, et al. Clin Adv Hematol Oncol 2003). The OSUCCC serves the catchment area of the state of Ohio where over 95% of our patients with cancer reside. Working closely with the OSUCCC Center for Cancer Health Equity (CCHE), OSUCCC National Outreach Network, community partner organizations, community providers in the OSUCCC referral area, James Hospital Network sites, NCI Community Oncology Research Program (NCORP) sites in Ohio, and the OSUCCC Clinical Trials Office, our goal will be accomplished by completing the following specific aims: 1) Conduct a baseline assessment of referral patterns and accrual of racial and ethnic minorities to clinical trials at OSUCCC by cancer disease group (breast, gastrointestinal, genitourinary, thoracic, hematologic, and others) and examine factors at the system (i.e., eligible clinical trial protocol, clinic context and culture), provider (trial discussed with patient), and patient level (agreed or refused participation) that influence referral and accrual (Phase I); 2) Implement a multi-level intervention in a stepped wedge design in referring practices in 9 counties with high counts of minority cancer cases in the OSUCCC catchment area using the Accrual to Clinical Trials framework (Paskett, et al. Clin Adv Hematol Oncol 2003), in Phase II. The intervention will include an outreach component, directed at community members and community practices, and an in-reach component, involving patients, providers, and the hospital system (at both referral centers and the OSUCCC) that directly addresses problems identified in Phase I; and 3) to evaluate the impact of the intervention on referral (primary outcome) and accrual patterns (secondary outcomes) in Phase III to clinical trials. Both qualitative and quantitative methods will be used. Dissemination of the key findings of our multi-level intervention is a high priority of this project.

项目概要俄亥俄州立大学 (OSU) 的总体目标是将代表性不足的人群与临床试验联系起来 (CUSP2CT) 旨在增加少数种族/族裔参加 NCI 国家临床试验的转诊和应计人数俄勒冈州立大学综合癌症中心 (OSUCCC) 的网络 (NCTN) 预防/控制和治疗试验。这项研究以人口健康中心开发的社会生态模型为基础差异（Warnecke 等人，Am J Public Health 2008）并利用理论模型，Accrual to Clinical 试验（Paskett 等人 Clin Adv Hematol Oncol 2003）。 OSUCCC 服务于该州的学区超过 95% 的癌症患者居住在俄亥俄州。与 OSUCCC 癌症中心密切合作健康公平 (CCHE)、OSUCCC 国家外展网络、社区合作伙伴组织、社区 OSUCCC 转诊区域的提供者、詹姆斯医院网络站点、NCI 社区肿瘤学研究俄亥俄州计划 (NCORP) 站点和 OSUCCC 临床试验办公室，我们的目标将通过完成以下具体目标： 1) 对推荐模式和应计进行基线评估按癌症疾病组（乳腺癌、胃肠道、泌尿生殖、胸部、血液等）并检查系统中的因素（即合格的临床试验协议、诊所背景和文化）、提供者（与患者讨论的试验）和患者级别（同意或拒绝）参与）影响推荐和累积（第一阶段）； 2）实施多层次、分阶段干预 OSUCCC 少数癌症病例数较高的 9 个县的转诊实践中的楔形设计使用临床试验应计框架（Paskett 等人 Clin Adv Hematol Oncol 2003）的服务区域，第二阶段。干预措施将包括针对社区成员和社区的外展部分实践，以及触及范围内的组成部分，涉及患者、提供者和医院系统（在转诊时）中心和 OSUCCC）直接解决第一阶段发现的问题； 3) 评估影响第三阶段对转诊（主要结果）和应计模式（次要结果）的干预临床试验。将使用定性和定量方法。传播我们的主要发现多层次干预是该项目的重中之重。