OSUCCC CUSP2CT

基本信息

批准号：
10540023
负责人：
CHERYL T. LEE
金额：
$ 70.88万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-12 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10540023
关键词：
Address African American Area Black race Breast Cancer Center Cancer Patient Catchment Area Centers for Population Health Chest Clinic Clinical Cancer Center Clinical Trials Clinical trial protocol document Communities Community Clinical Oncology Program Community Health Aides Community Hospitals Community Outreach Community Practice Comprehensive Cancer Center County Detection Disease Education Enrollment Ethnic group Fostering Genitourinary system Goals Health system Healthcare Systems Hematology Hispanic Hospitals Institution Intervention Intervention Trial Left Malignant Neoplasms Methods Minority Modality Modeling National Clinical Trials Network Ohio Outcome Patients Pattern Persons Phase Population Population Group Prevention Process Provider Public Health Race Research Resources Risk Site System Theoretical model Therapeutic Intervention Touch sensation Underrepresented Populations Universities Work bilingualism biomedical referral center black patient cancer health disparity cancer prevention cancer referral center clinical practice community partnership control trial design ethnic minority experience gastrointestinal health disparity health disparity populations health equity improved member minority communities outreach primary outcome programs racial and ethnic racial minority racial minority population secondary outcome success treatment trial

项目摘要

PROJECT SUMMARY The overall goal of The Ohio State University (OSU) Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) is to increase the referral and accrual of racial/ethnic minorities to NCI's National Clinical Trials Network (NCTN) prevention/control and treatment trials at the OSU Comprehensive Cancer Center (OSUCCC). This research is grounded in the socioecologic model developed by the Centers for Population Health and Health Disparities (Warnecke, et al. Am J Public Health 2008) and utilizes the theoretical model, Accrual to Clinical Trials (Paskett, et al. Clin Adv Hematol Oncol 2003). The OSUCCC serves the catchment area of the state of Ohio where over 95% of our patients with cancer reside. Working closely with the OSUCCC Center for Cancer Health Equity (CCHE), OSUCCC National Outreach Network, community partner organizations, community providers in the OSUCCC referral area, James Hospital Network sites, NCI Community Oncology Research Program (NCORP) sites in Ohio, and the OSUCCC Clinical Trials Office, our goal will be accomplished by completing the following specific aims: 1) Conduct a baseline assessment of referral patterns and accrual of racial and ethnic minorities to clinical trials at OSUCCC by cancer disease group (breast, gastrointestinal, genitourinary, thoracic, hematologic, and others) and examine factors at the system (i.e., eligible clinical trial protocol, clinic context and culture), provider (trial discussed with patient), and patient level (agreed or refused participation) that influence referral and accrual (Phase I); 2) Implement a multi-level intervention in a stepped wedge design in referring practices in 9 counties with high counts of minority cancer cases in the OSUCCC catchment area using the Accrual to Clinical Trials framework (Paskett, et al. Clin Adv Hematol Oncol 2003), in Phase II. The intervention will include an outreach component, directed at community members and community practices, and an in-reach component, involving patients, providers, and the hospital system (at both referral centers and the OSUCCC) that directly addresses problems identified in Phase I; and 3) to evaluate the impact of the intervention on referral (primary outcome) and accrual patterns (secondary outcomes) in Phase III to clinical trials. Both qualitative and quantitative methods will be used. Dissemination of the key findings of our multi-level intervention is a high priority of this project.

项目摘要俄亥俄州立大学（OSU）将代表性不足的人群与临床试验联系起来的总体目标（cusp2ct）是将种族/族裔少数民族的转诊和应计向NCI的国家临床试验增加 OSU综合癌症中心（OSUCCC）的网络（NCTN）预防/控制和治疗试验。这项研究基于人口健康中心开发的社会生态学模型差异（Warnecke等人，AM J公共卫生2008），并利用理论模型，应计为临床试验（Paskett等人Clin Adv Hematol Oncol 2003）。 OSUCCC为州的集水区服务俄亥俄州有超过95％的癌症患者居住。与OSUCCC癌症中心紧密合作健康平等（CCHE），OSUCCC国家外展网络，社区合作伙伴组织，社区 OSUCCC推荐区，James Hospital Network网站，NCI社区肿瘤学研究的提供商俄亥俄州的计划（NCORP）网站和OSUCCC临床试验办公室，我们的目标将由完成以下具体目的：1）对转介模式进行基线评估和应计。癌症组（乳腺癌，胃肠道，泌尿生殖器，胸腔，血液学等）并检查系统中的因素（即合格的临床试验协议，诊所背景和文化），提供者（与患者讨论的试验）和患者级别（同意或拒绝参与）影响推荐和应计（I阶段）； 2）在阶梯上实施多层次干预在OSUCCC中，在9个县的参考实践中的楔形设计使用应计到临床试验框架的集水区（Paskett等，Clin Adv Hematol Oncol 2003），第二阶段。干预措施将包括针对社区成员和社区的外展部分练习和涉及患者，提供者和医院系统的范围内部分子（在两个转介中直接解决I期中确定的问题的中心和OSUCCC）； 3）评估影响第三阶段的转诊（主要结果）和应计模式（次要结果）的干预措施临床试验。将使用定性和定量方法。传播我们的主要发现多层次干预是该项目的高度优先事项。