FASD Diagnostic Telemedicine Resource

FASD 诊断远程医疗资源

基本信息

批准号：
10703404
负责人：
Miguel del Campo Casanelles
金额：
$ 35.51万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703404
关键词：
3-Dimensional Address Adult Alaska Alcohols Algorithms Area Brain Characteristics Child Clinic Clinical Collaborations Communities Complement Computers Detection Development Diagnosis Diagnostic Diagnostic Imaging Diagnostic Services Dysmorphology Early Intervention Ensure Evaluation Face Failure Fetal Alcohol Exposure Fetal Alcohol Spectrum Disorder Funding Genes Goals Health Personnel Healthcare Image Improve Access Individual Intervention Life Live Birth Measurement Methods Modality Monitor Patient Recruitments Persons Physical assessment Probability Provider Public Health Research Research Personnel Resources Sampling Services Site Standardization Syndrome Telemedicine Testing Training Trees Work accurate diagnosis cost diagnostic accuracy disease classification eHealth effectiveness evaluation feature detection fetal diagnosis geographic barrier health training improved novel prenatal screening smartphone application tool

项目摘要

Project Summary Prenatal alcohol exposure is estimated to impact 1-5% of children in the US alone. Yet, many individuals who have been exposed prenatally to alcohol and suffer from fetal alcohol spectrum disorders (FASD) fail to be recognized. This failure is due, in large part, to a paucity of specialized clinics and expert dysmorphologists who are trained to identify FASD. Access to appropriate diagnostic expertise is particularly limited in remote areas. Unfortunately, if individuals with FASD are not recognized and diagnosed, they do not receive critically needed services nor can they access potential interventions early in life, when intervention is most likely to be effective. The CIFASD5 Diagnostic-Telemedicine Resource (DTR) will ensure consistent and accurate assessment of the physical characteristics of FASD across the CIFASD research sites. In addition, the DTR will address the critical need for increased diagnostic capacity through training of non-expert practitioners across CIFASD5 sites using telemedicine-based methods. In the previous CIFASD4 iteration, telemedicine approaches were tested for this purpose in a small sample of clinicians and found to be an effective method for training and monitoring of new examiners. In CIFASD5, this method will be extended to multiple sites and be employed in the evaluation of over 1,800 children and adults. However, telemedicine alone is insufficient to expand capacity and ensure consistency and accuracy of diagnosis. To that end, several novel eHealth tools have been developed to assist in the detection of physical features associated with prenatal alcohol exposure. These tools hold promise in providing simple and efficient ways to screen and identify FASD. These include MorpheusQ, a smart-phone based app that automates facial feature detection; Face-to-Gene, a 2D facial image diagnostic aid used by clinical geneticists to screen for potential syndromes; and 3D facial image signatures. These tools are scalable and have the potential to improve screening and diagnosis across the globe, even in remote areas, such as in Alaska. However, the diagnostic accuracy of these tools needs to be systematically compared to standardized dysmorphological exams. It is essential to determine whether eHealth tools can effectively replace and/or improve traditional exams before they are widely implemented.

项目概要据估计，仅在美国就有 1-5% 的儿童受到产前酒精暴露的影响。然而，许多产前接触过酒精并患有胎儿酒精谱系的人士疾病（FASD）未能被识别。这种失败在很大程度上是由于缺乏专门的接受过识别 FASD 培训的诊所和畸形专家。获得适当的在偏远地区，诊断专业知识尤其有限。不幸的是，如果患有 FASD 的人没有被识别和诊断，他们没有获得急需的服务，也不能在生命早期接受潜在的干预措施，此时干预措施最有可能有效。 CIFASD5 诊断远程医疗资源 (DTR) 将确保一致和准确对 CIFASD 研究中心的 FASD 身体特征进行评估。在此外，DTR 将通过培训满足提高诊断能力的迫切需求使用基于远程医疗的方法跨 CIFASD5 站点的非专家从业者的数量。在在之前的 CIFASD4 迭代中，远程医疗方法为此目的进行了小型测试临床医生样本，并被发现是培训和监测新患者的有效方法考官。在CIFASD5中，该方法将扩展到多个站点并应用于对 1,800 多名儿童和成人进行了评估。然而，仅远程医疗不足以扩大容量并确保一致性和诊断的准确性。为此，开发了几种新颖的电子卫生工具来协助检测与产前酒精暴露相关的身体特征。这些工具持有承诺提供简单有效的方法来筛查和识别 FASD。这些包括 MorpheusQ，一款基于智能手机的应用程序，可自动检测面部特征；面对面基因，临床遗传学家使用 2D 面部图像诊断辅助工具来筛查潜在的综合症；和 3D 面部图像签名。这些工具具有可扩展性，有潜力改善筛查并在全球范围内进行诊断，甚至在偏远地区，例如阿拉斯加。然而，诊断这些工具的准确性需要与标准化的畸形学进行系统比较考试。确定电子卫生工具是否可以有效替代和/或改进至关重要传统考试在广泛实施之前。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Altered Parietal Activation during Non-symbolic Number Comparison in Children with Prenatal Alcohol Exposure.

产前酒精暴露儿童在非符号数字比较过程中顶叶激活发生变化

DOI：
10.3389/fnhum.2017.00627
发表时间：
2017
期刊：
Frontiers in human neuroscience
影响因子：
2.9
作者：
Woods KJ;Jacobson SW;Molteno CD;Jacobson JL;Meintjes EM
通讯作者：
Meintjes EM

An auditory Go/No-Go study of event-related potentials in children with fetal alcohol spectrum disorders.

胎儿酒精谱系障碍儿童事件相关电位的听觉 Go/No-Go 研究。

DOI：
10.1109/iembs.2011.6090181
发表时间：
2011
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
0
作者：
Steinmann,TobiasP;Andrew,ColinM;Thomsen,CarstenE;Kjær,TroelsW;Meintjes,ErnestaM;Molteno,ChristopherD;Jacobson,JosephB;Jacobson,SandraW;Sorensen,HelgeBD
通讯作者：
Sorensen,HelgeBD

Developmental pathogenesis of short palpebral fissure length in children with fetal alcohol syndrome.

胎儿酒精综合征儿童睑裂长度短的发育发病机制。

DOI：
10.1002/bdra.20585
发表时间：
2009
期刊：
Birth defects research. Part A, Clinical and molecular teratology
影响因子：
0
作者：
Jones,KennethLyons;Hoyme,HEugene;Robinson,LutherK;delCampo,Miguel;Manning,MelanieA;Bakhireva,LudmilaN;Prewitt,LelaM;Chambers,ChristinaD
通讯作者：
Chambers,ChristinaD

Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders.

患有胎儿酒精谱系障碍的儿童在数字处理过程中的顶叶功能障碍。

DOI：
10.1016/j.nicl.2015.03.023
发表时间：
2015
期刊：
NeuroImage. Clinical
影响因子：
0
作者：
Woods,KJ;Meintjes,EM;Molteno,CD;Jacobson,SW;Jacobson,JL
通讯作者：
Jacobson,JL

Fetal alcohol spectrum disorders: Extending the range of structural defects.

DOI：
10.1002/ajmg.a.33675
发表时间：
2010-11
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
影响因子：
2
作者：
Jones, Kenneth Lyons;Hoyme, H. Eugene;Robinson, Luther K.;del Campo, Miguel;Manning, Melanie A.;Prewitt, Lela M.;Chambers, Christina D.
通讯作者：
Chambers, Christina D.