Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma

调整和测试一种新颖的自我慈悲干预措施以减少肺癌耻辱感

基本信息

批准号：
10679062
负责人：
Timothy J Williamson
金额：
$ 13.54万
依托单位：
LOYOLA MARYMOUNT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10679062
关键词：
Address Adult Anxiety Area Attenuated Basic Behavioral Science Behavioral Behavioral Research Behavioral Sciences Breathing Cancer Control Cancer Intervention Cancer Patient Clinical Cognition Compassion Competence Data Development Diagnosis Disease Disease Progression Distress Feeling Focus Groups Future Goals Health Health Sciences Individual Intervention Interview Investigation Link Malignant Neoplasms Malignant neoplasm of lung Maps Measures Meditation Memorial Sloan-Kettering Cancer Center Mental Health Mentors Mentorship Methods Oncology Outcome Participant Patients Perception Persons Phase Population Positioning Attribute Process Protocols documentation Psychosocial Influences Public Health Quality of life Reaction Regrets Reporting Research Research Personnel Sampling Shame Site Smoking Source Stressful Event Structure Testing Training Translating Translations United States National Institutes of Health behavioral and social science cancer care career development depressive symptoms design efficacy testing experience improved internalized stigma lung cancer screening mindfulness novel patient population physical conditioning pilot test post intervention preference psychoeducation psychoeducational psychologic psychosocial randomized, clinical trials responders and non-responders screening secondary outcome social influence social science research social stigma standard of care statistics synergism telehealth theories therapy development understudied cancer

项目摘要

Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030. Nearly all (95%) patients diagnosed with lung cancer report experiencing stigma (i.e., the perception and internalization of negative appraisal from others attributed to one’s lung cancer), which is perhaps the most prominent psychosocial issue in this population and contributes to poor psychological and physical health outcomes. A critical gap in the field of cancer control science is the lack of empirically supported patient-focused interventions that target the reduction of lung cancer stigma for this growing patient population. The goals of this K99/R00 are to adapt the existing Mindful Self-Compassion (MSC) psychosocial intervention to address anticipated delivery challenges and target the reduction of lung cancer stigma as well as to seek preliminary evidence for the efficacy of the adapted MSC intervention in reducing lung cancer stigma. The K99 study will involve a two-phase process of 1) conducting stakeholder focus groups to guide the iterative adaptation of MSC intervention activities and materials and 2) conducting in-depth interviews with lung cancer patients to explore patients’ reactions to intervention content and preferences for format and delivery. The R00 study will involve a two-phase process of 1) conducting a pilot RCT (n=60) to test preliminary efficacy of the adapted MSC intervention on primary (lung cancer stigma) and secondary outcomes (depressive symptoms, quality of life) and 2) conducting interviews with purposively sampled high responders (n=10) and non-responders (n=10) from the MSC condition (assessed post-intervention) to examine participants’ reactions to study participation. The overall objective of this K99/R00 is to provide Dr. Williamson with additional training and mentorship to become an independent cancer control investigator translating findings from basic behavioral scientific research into the development of tailored psychosocial interventions for cancer patients. Training aims include: 1) Psychosocial intervention development and adaptation in cancer; 2) advanced qualitative and mixed-methods design and analysis; 3) translational psychological research (synergy between basic and applied health science); 4) delivery of mindfulness- and compassion-based interventions in cancer care; and 5) professional development. Dr. Williamson is mentored by Dr. Jamie Ostroff at Memorial Sloan Kettering Cancer Center along with expert support from co-mentors (Drs. Lisa Carter-Harris and Jun Mao) and other significant contributors (Dr. Christopher Germer, Ms. Kathleen Lynch), who are all committed to Dr. Williamson’s career development. The proposed training plan will facilitate Dr. Williamson’s transition to independence as a cancer control investigator conducting a programmatic line of research that 1) characterizes disease-specific challenges of understudied cancer groups and 2) translates findings from basic behavioral research into tailored psychosocial interventions that address such challenges and ultimately enhance quality of life.

项目概要鉴于筛查和治疗方面的进步，美国肺癌患者人数预计到 2030 年将增加 25%（从 571,340 人增加到 724,610 人）。几乎所有 (95%) 的患者都被诊断患有肺癌报告经历耻辱（即，对来自他人的负面评价的感知和内化）其他归因于肺癌），这可能是该领域最突出的心理社会问题人口并导致不良的心理和身体健康结果。癌症控制科学缺乏经验支持的以患者为中心的干预措施 K99/R00 的目标是减少肺癌患者群体的耻辱感。现有的正念自我同情 (MSC) 心理社会干预，以解决预期的交付挑战并以减少肺癌耻辱感为目标，并寻求肺癌疗效的初步证据 K99 研究将涉及两个阶段的过程：调整 MSC 干预以减少肺癌耻辱感。 1) 召开利益相关者焦点小组会议，指导 MSC 干预活动的迭代调整；材料和2）对肺癌患者进行深入访谈，探讨患者的反应 R00 研究将涉及两个阶段的过程。 1) 进行试点随机对照试验 (n=60)，以测试调整后的 MSC 干预对原发性（肺癌耻辱）和次要结果（抑郁症状、生活质量）和 2) 进行对来自 MSC 的有目的地抽样的高反应者 (n=10) 和无反应者 (n=10) 进行访谈条件（干预后评估）来检查参与者对研究参与的反应。 K99/R00 的目标是为 Williamson 博士提供额外的培训和指导，使其成为一名独立的癌症控制调查员将基础行为科学研究的结果转化为为癌症患者制定量身定制的社会心理干预措施，培训目标包括： 1) 社会心理干预。癌症干预措施的开发和适应；2）先进的定性和混合方法设计和分析；3）转化心理学研究（基础和应用健康科学之间的协同）；在癌症护理中提供基于正念和同情心的干预措施；以及 5) 专业的干预措施； Williamson 博士由纪念斯隆·凯特琳癌症中心的 Jamie Ostroff 博士指导。以及联合导师（Lisa Carter-Harris 博士和 Jun Mao 博士）和其他重要专家的专家支持贡献者（克里斯托弗·杰默博士、凯瑟琳·林奇女士），他们都致力于威廉姆森博士的职业生涯拟议的培训计划将有助于威廉姆森博士作为一名独立人士过渡。癌症控制研究人员进行一系列研究，1) 描述疾病特异性未充分研究的癌症群体面临的挑战，2) 将基础行为研究的发现转化为量身定制的心理社会干预措施可以应对这些挑战并最终提高生活质量。