Function Assessment Core

功能评估核心

• 批准号: 10678834
• 负责人: Roger A. Fielding
• 金额: $ 18.08万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678834
• 关键词: Activities of Daily Living; Address; Aging; Animals; Area; Behavior; Boston; COVID-19 pandemic; Caenorhabditis elegans; Calibration; Certification; Clinical Research; Clinical Trials; Collaborations; Development; Elderly; Environment; Equipment; Evaluation; Exercise Physiology; Face; Goals; Human; Human Resources; Impairment; Infection Control; Infrastructure; Intervention Studies; Leadership; Maintenance; Measurement; Measures; Movement; Muscle; Musculoskeletal; Nutritional Study; Observational Study; Older Population; Performance; Physical Function; Physical assessment; Procedures; Protocols documentation; Quality Control; Quality of life; Research Personnel; Services; Societies; Standardization; Structure; Techniques; Technology; Training; Walking; Woman; clinical development; disability; efficacy evaluation; experience; hospital laboratories; innovation; instrument; interdisciplinary collaboration; novel; physically handicapped; preservation; procedure safety; tool; translational approach

SUMMARY / ABSTRACT Preserving late-life mobility, defined as the ability to walk safely and independently, is central to maintaining a high quality of life, is critical for the performance of many activities of daily living and is necessary for maintaining physical independence. Therefore, the continued development and standardization of tools that can reliably assess physical functioning and disability status will be important for addressing the growing challenge that societies worldwide will face with the expanding older population. The physical function assessment core seeks to continue to provide the necessary infrastructure to perform standardized, valid and reliable measures of musculoskeletal impairments, physical function, and disability across the spectrum of observational studies and clinical trials embedded within, supported by, or associated with the Boston-OIAC. The leadership of this core has collaborated extensively over the past project period, has unique experience in the application of these measurements across a wide range of cross-sectional and intervention studies in older adults, and has been on the leading edge of the development and refinement of new instruments and technologies to assess domains of physical function and disability. We propose to examine the following specific aims: Aim 1: We will provide an organized infrastructure for FAC-supported procedures and activities across Tufts’ Human Nutrition Research Center on Aging, and Brigham and Women’s Hospital Laboratory of Exercise Physiology and Physical Function and serve as focal point for interdisciplinary collaboration by OAIC investigators in the development, evaluation, and application of new and existing tools and instruments to assess musculoskeletal impairments, physical function, and disability in older adults to evaluate the efficacy of function promoting therapies. Aim 2: We will provide direct measurement and consultative services, as well as assist with proposal development for clinical studies supported by, or associated with, the theme of the OAIC that require measures of musculoskeletal impairments, physical function, and/or disability. All Core services will use standardized equipment and operating protocols for the assessment of muscle performance and functional limitations in human studies, and will maintain extensive quality control procedures including: personnel training and certification; equipment maintenance; and quality control. Aim 3: We will develop novel and innovative approaches to assess musculoskeletal impairments, physical function, and disability in older adults. The FAC will also support innovative developmental projects that seek to develop or further validate innovative approaches to assess musculoskeletal impairments, physical function, and disability in older adults.

摘要 /摘要 保留后期生活的流动性，定义为安全和独立行走的能力，对于维持 高质量的生活，对于许多日常生活的表现至关重要，对于 保持身体独立。因此，工具的持续开发和标准化 可以可靠地评估身体功能和残疾状况对于解决增长的问题很重要 挑战全世界社会将面对不断增长的老年人。身体功能 评估核心试图继续提供必要的基础架构，以执行标准化，有效和 可靠测量肌肉骨骼障碍，身体机能和残疾的可靠测量 观察性研究和与波士顿OIAC相关的，支持或相关的临床试验。 在过去的项目期间，该核心的领导作用已广泛合作，在 这些测量在较旧的横断面和干预研究中的应用 成人，并且一直处于开发和完善新工具的领先地位， 评估身体机能和残疾领域的技术。 我们建议检查以下具体目标： AIM 1：我们将提供一个有组织的基础设施，用于跨簇的FAC支持程序和活动 人类衰老的人类营养研究中心，杨百翰和妇女医院运动实验室 生理学和身体功能，并成为OAIC跨学科合作的焦点 开发，评估和应用新工具和工具的调查人员 评估老年人的肌肉骨骼障碍，身体机能和残疾，以评估 促进疗法的功能。 AIM 2：我们将提供直接的测量和咨询服务，并协助提案 临床研究的开发由OAIC的主题支持或与需要测量的主题相关联 肌肉骨骼障碍，身体功能和/或残疾的障碍。所有核心服务将使用标准化 设备和操作方案，用于评估肌肉性能和功能限制 人类研究，并将维护广泛的质量控制程序，包括：人事培训和 认证;设备维护；和质量控制。 目标3：我们将开发出新颖和创新的方法来评估肌肉骨骼障碍，身体 老年人的功能和残疾。 FAC还将支持寻求创新的发展项目 开发或进一步验证创新方法来评估肌肉骨骼障碍，身体机能， 和老年人的残疾。