Function Assessment Core

功能评估核心

• 批准号: 10470355
• 负责人: Roger A. Fielding
• 金额: $ 21.18万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470355
• 关键词: Activities of Daily Living; Address; Aging; Animals; Area; Behavior; Boston; COVID-19 pandemic; Caenorhabditis elegans; Calibration; Certification; Clinical Research; Clinical Trials; Consultations; Cross-Sectional Studies; Development; Elderly; Environment; Equipment; Evaluation; Exercise Physiology; Face; Goals; Human; Human Resources; Impairment; Infection Control; Infrastructure; Intervention Studies; Leadership; Maintenance; Measurement; Measures; Movement; Muscle; Musculoskeletal; Nutritional Study; Observational Study; Older Population; Performance; Physical Function; Procedures; Protocols documentation; Quality Control; Quality of life; Research Personnel; Services; Societies; Standardization; Structure; Techniques; Technology; Training; Walking; Woman; clinical development; disability; efficacy evaluation; experience; hospital laboratories; innovation; instrument; interdisciplinary collaboration; novel; physically handicapped; preservation; procedure safety; tool; translational approach

SUMMARY / ABSTRACT Preserving late-life mobility, defined as the ability to walk safely and independently, is central to maintaining a high quality of life, is critical for the performance of many activities of daily living and is necessary for maintaining physical independence. Therefore, the continued development and standardization of tools that can reliably assess physical functioning and disability status will be important for addressing the growing challenge that societies worldwide will face with the expanding older population. The physical function assessment core seeks to continue to provide the necessary infrastructure to perform standardized, valid and reliable measures of musculoskeletal impairments, physical function, and disability across the spectrum of observational studies and clinical trials embedded within, supported by, or associated with the Boston-OIAC. The leadership of this core has collaborated extensively over the past project period, has unique experience in the application of these measurements across a wide range of cross-sectional and intervention studies in older adults, and has been on the leading edge of the development and refinement of new instruments and technologies to assess domains of physical function and disability. We propose to examine the following specific aims: Aim 1: We will provide an organized infrastructure for FAC-supported procedures and activities across Tufts’ Human Nutrition Research Center on Aging, and Brigham and Women’s Hospital Laboratory of Exercise Physiology and Physical Function and serve as focal point for interdisciplinary collaboration by OAIC investigators in the development, evaluation, and application of new and existing tools and instruments to assess musculoskeletal impairments, physical function, and disability in older adults to evaluate the efficacy of function promoting therapies. Aim 2: We will provide direct measurement and consultative services, as well as assist with proposal development for clinical studies supported by, or associated with, the theme of the OAIC that require measures of musculoskeletal impairments, physical function, and/or disability. All Core services will use standardized equipment and operating protocols for the assessment of muscle performance and functional limitations in human studies, and will maintain extensive quality control procedures including: personnel training and certification; equipment maintenance; and quality control. Aim 3: We will develop novel and innovative approaches to assess musculoskeletal impairments, physical function, and disability in older adults. The FAC will also support innovative developmental projects that seek to develop or further validate innovative approaches to assess musculoskeletal impairments, physical function, and disability in older adults.

摘要/摘要 保持晚年的活动能力（定义为安全、独立行走的能力）是维持晚年生活的核心 高品质的生活对于许多日常生活活动的进行至关重要，并且对于 因此，工具的持续开发和标准化。 能够可靠地评估身体机能和残疾状况对于解决日益增长的问题非常重要 随着老年人口的不断增加，世界各地的社会都将面临挑战。 评估核心力求继续提供必要的基础设施，以执行标准化、有效和 跨范围的肌肉骨骼损伤、身体功能和残疾的可靠测量 嵌入 Boston-OIAC、由 Boston-OIAC 支持或与之相关的观察性研究和临床试验。 该核心领导层主要在过去的项目期间进行了合作，在以下方面拥有独特的经验： 这些测量在老年人的广泛横断面和干预研究中的应用 成人，并一直处于新乐器和改进的开发和完善的前沿。 评估身体功能和残疾领域的技术。 我们建议研究以下具体目标： 目标 1：我们将为塔夫茨大学 FAC 支持的程序和活动提供有组织的基础设施 人类衰老营养研究中心和布莱根妇女医院运动实验室 生理学和身体功能，并作为 OAIC 跨学科合作的焦点 研究人员开发、评估和应用新的和现有的工具和仪器 评估老年人的肌肉骨骼损伤、身体功能和残疾，以评估其疗效 功能促进疗法。 目标2：我们将提供直接测量和咨询服务，并协助提案 由 OAIC 主题支持或与之相关的需要采取措施的临床研究的发展 肌肉骨骼损伤、身体功能和/或残疾的所有核心服务都将使用标准化。 用于评估肌肉性能和功能限制的设备和操作方案 人体研究，并将维持广泛的质量控制程序，包括：人员培训和 认证；设备维护；和质量控制。 目标 3：我们将开发新颖和创新的方法来评估肌肉骨骼损伤、身体损伤 FAC 还将支持旨在寻求老年人功能和残疾的创新发展项目。 开发或进一步验证评估肌肉骨骼损伤、身体功能的创新方法， 和老年人的残疾。