2020 Immunometabolism in Health and Disease GRC

2020 健康与疾病中的免疫代谢 GRC

• 批准号: 9912281
• 负责人: Hongbo Chi
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912281
• 关键词: Academia; Address; Allergic; Atherosclerosis; Atmosphere; Autoimmunity; Bioenergetics; Cell physiology; Cells; Cellular biology; Clinical; Collaborations; Communicable Diseases; Conflict (Psychology); Consultations; Country; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Ensure; Entrepreneurship; Equilibrium; Fostering; Goals; Health; Host Defense; Human; Hypersensitivity; Immune; Immune System Diseases; Immune response; Immunity; Immunology; Industrialization; Industry; Infection; Inflammatory Response; International; Intervention; Investigation; Learning; Lymphocyte Function; Lymphoid; Lymphoid Cell; Malignant Neoplasms; Mediating; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Methods; Minority; Minority Groups; Mission; Modeling; Myelogenous; Myeloid Cells; National Institute of Allergy and Infectious Disease; Natural Immunity; Nature; Obesity; Oral; Peer Review; Pharmacologic Substance; Research; Research Personnel; Resolution; Rhode Island; Role; Science; Scientist; Second Messenger Systems; Seeds; Sterols; T-Lymphocyte; Technology; Therapeutic; Time; Training; Translations; Underrepresented Minority; United States; Universities; Woman; Work; adaptive immunity; career; catalyst; immune function; improved; innovation; insight; interest; meetings; member; microbiota; new therapeutic target; next generation; posters; programs; sensor; symposium; therapeutic target; tumor immunology; tumor microenvironment

Project Summary/Abstract The 2020 Gordon Research Conference (GRC) on Immunometabolism in Health and Disease, subtitled `Cellular metabolism in immunity: basic and translational', will be the inaugural GRC on the interface of cellular metabolism and immunity (or “immunometabolism”), a cutting-edge, emerging field in immunology. Recent studies indicate that cellular metabolism serves as both a fundamental mechanistic driver of and intervenable therapeutic target in infectious, allergic, and other immune-mediated diseases. The realization that metabolism is reprogrammed during the immune response and that bioenergetic and other metabolites are `repurposed' to modulate immune functions has led to a recent paradigm shift. As this young and interdisciplinary field accelerates, there is a critical need to convene experts and trainees alike. To this end, we are holding a meeting at Bryant University in Smithfield, Rhode Island from June 21–26, 2020. We are assembling international experts, both from academia and industry, on the role of cellular metabolism in the programming of myeloid and lymphoid immune cells in immunity and disease, and thus expect to foment productive, high-level discussions and collaborations, as well as significant interest among early-career investigators and trainees. Among the Specific Aims of our meeting are presentation of cutting-edge unpublished science, discussion and resolution of current controversies in the field, identification/prioritization of unmet needs in the field, stimulation of new collaborations, and provision of a comfortable and productive forum for trainees and early-stage investigations to learn and share their findings. The Co-Chairs, Drs. Michael Fessler and Hongbo Chi, in consultation with the Vice Chairs (Drs. Jeffrey Rathmell and Kathryn Moore) and other field leaders, have planned nine oral sessions to promote dialogue among established leaders in immunometabolism and emerging experts ranging from trainees to early-career scientists: Session 1 - Repurposing of Bioenergetics in Innate Immunity and Short Talks. Session 2 - Metabolic Programming of Lymphocyte Function. Session 3 - Trained Immunity, and Short Talks. Session 4 - Sterols in Immunity. Session 5 - Immunity and Microbiota as a Driver of Metabolic Disease. Session 6 - Immunometabolism of the Tumor Microenvironment. Session 7 - Metabolism in Host Defense, and Short Talks. Session 8 - Cell Fate in Immunometabolism. Session 9 - Emerging Opportunities for Intervening upon Immunometabolism in Disease. The speakers and discussion leaders are diverse and inclusive, including women (29%), early-stage investigators (16%), underrepresented minority groups (10%) and international experts from five countries outside the US. The focus of our conference directly meets the mission and goals of NIAID towards advancing intervenable insights into infectious, allergic, and immune-mediated diseases, and we are honored to invite members of NIAID administration as attendees. Our meeting agenda addresses diverse topics related to the crosstalk between immunity and metabolism in myeloid and lymphoid cells in immune- mediated diseases, including infection, allergy, autoimmunity, cancer, atherosclerosis, obesity, and diabetes.

项目概要/摘要 2020 年戈登健康与疾病免疫代谢研究会议 (GRC)，副标题 “免疫中的细胞代谢：基础和转化”，将是细胞界面上的首个 GRC 代谢和免疫（或“免疫代谢”）是免疫学的一个前沿、新兴领域。 研究表明，细胞代谢既是基本的机械驱动因素，也是可干预的 感染性、过敏性和其他免疫介导疾病的治疗靶标的实现。 在免疫反应过程中被重新编程，生物能和其他代谢物被“重新利用” 作为一个年轻的跨学科领域，调节免疫功能导致了最近的范式转变。 加速，迫切需要召集专家和学员，为此，我们正在召开一次会议。 2020 年 6 月 21 日至 26 日在罗德岛州史密斯菲尔德的布莱恩特大学举行。我们正在召集国际 来自学术界和工业界的专家研究了细胞代谢在骨髓和细胞编程中的作用 淋巴免疫细胞在免疫和疾病中的作用，因此有望引发富有成效的高层讨论 和合作，以及早期职业研究人员和实习生的浓厚兴趣。 我们会议的具体目标是介绍未发表的前沿科学、讨论和解决方案 该领域当前的争议、该领域未满足的需求的识别/优先排序、新的刺激 合作，并为学员和早期调查提供舒适且富有成效的论坛 联合主席 Michael Fessler 博士和 Hongbo Chi 博士与委员会协商，了解并分享他们的发现。 副主席（Jeffrey Rathmell 博士和 Kathryn Moore 博士）和其他领域领导者计划了九场口头会议 促进免疫代谢领域知名领导者和新兴专家之间的对话 早期职业科学家的受训者：第 1 节 - 生物能量学在先天免疫中的重新利用和简短的谈话。 第 2 节 - 淋巴细胞功能的代谢编程。第 3 节 - 训练后的免疫力和简短的谈话。 第 4 节 - 免疫中的甾醇。第 5 节 - 免疫和微生物群作为代谢疾病的驱动因素。 第 6 节 - 肿瘤微环境的免疫代谢 第 7 节 - 宿主防御中的代谢，以及 简短的演讲第 8 节 - 免疫代谢中的细胞命运第 9 节 - 干预的新机会。 疾病中的免疫代谢问题的演讲者和讨论领导者是多元化和包容性的，包括 女性（29%）、早期研究人员（16%）、代表性不足的少数群体（10%）和国际 来自美国以外五个国家的专家。我们会议的重点直接符合我们的使命和目标。 NIAID 对传染性、过敏性和免疫介导疾病的可干预见解，我们 我们很荣幸邀请 NIAID 管理人员作为与会者，我们的会议议程涉及不同的内容。 与免疫和免疫中骨髓细胞和淋巴细胞的代谢之间的串扰相关的主题 介导的疾病，包括感染、过敏、自身免疫、癌症、动脉粥样硬化、肥胖和糖尿病。