Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children

接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险

• 批准号: 10678857
• 负责人: Catherine Metayer
• 金额: $ 63.02万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-03 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10678857
• 关键词: Accidents; Accounting; Adolescent; Adult; Age; Archives; Area; Attention; Biological Markers; Biological Monitoring; Birth; Blood; Blood specimen; Body Burden; Breast Feeding; Calibration; California; Cancer Cluster; Central Nervous System; Chemicals; Child; Childhood Leukemia; Communities; County; Data; Diet; Drug Kinetics; Dryness; Dust; Environment; Environmental Engineering technology; Environmental Health; Ethnic Origin; Exposure to; Food; Geographic Locations; Health; Home; House Dust; Human; Infant; Ingestion; Institution; Intake; Kidney; Knowledge; Laboratories; Life; Link; Los Angeles; Lymphoma; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Measurement; Measures; Methodology; Methods; Modeling; Mothers; Needs Assessment; Neonatal; Newborn Infant; Oranges; Outcome; Participant; Pediatric epidemiology; Phase; Poly-fluoroalkyl substances; Population; Pregnancy; Race; Renal carcinoma; Reporting; Research; Research Personnel; Residential Mobility; Resources; Rhabdomyosarcoma; Risk; Risk Estimate; Route; Sampling; Serum; Site; Spottings; Statistical Data Interpretation; Testing; Testis; Thyroid Gland; Translational Research; Universities; Water; age group; analytical method; cancer epidemiology; cancer risk; cancer site; case control; contaminated drinking water; contaminated water; design; drinking water; early childhood; early life exposure; early onset; epidemiology study; exposure route; high risk; improved; innovation; leukemia; manufacture; novel; older patient; pharmacokinetic model; postnatal; prenatal; prenatal exposure; programs; residence; screening; sex; synergism; virtual

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) have been used in many manufacturing and commercial products in recent decades, resulting in widespread and persistent contamination despite the phasing out of early compounds such as PFOS and PFOA. Routes of PFAS exposure to humans vary by age; while exposures in infants and children are commonly from breastfeeding and ingestion of settled dust, adolescents and adults are primarily exposed through food and water. PFAS have been associated with several adverse health outcomes, including cancer in adults. Despite several reports of childhood cancer clusters in PFAS-contaminated areas, and potentially higher body burdens in children compared to adults, no studies have systematically assessed cancer risk in children, due, in part to the relative rarity of childhood cancer. We propose to conduct the first study of PFAS and cancer in children, by integrating the expertise of investigators from four institutions, forming a transdisciplinary virtual consortium with expertise in pediatric and cancer epidemiology, and environmental engineering and health sciences. Using innovative methodology, this virtual consortium will characterize PFAS from the most relevant routes of exposure by examining PFAS in drinking water (Aim 1), newborn and pregnancy blood samples (Aim 2), and household dust (Aim 3) during vulnerable exposure windows from pregnancy through early childhood, and subsequent risk of developing childhood cancer. We will focus on cancers that have been reported previously in communities and groups known to have high exposures to PFAS, such as leukemia, rhabdomyosarcoma, lymphoma, and cancers of the brain, central nervous system, kidney, testis, and thyroid. We will leverage two existing California childhood cancer studies with complementary designs offering large number of childhood cancer cases and controls with residential information, and with access to blood and dust samples for subsets. PFAS water exposure assessment, we will use a Bayesian pharmacokinetic calibration approach that combines measured drinking water concentrations with measured serum biomarkers to provide improved exposure estimates. We will also combine targeted and non-targeted mass spectrometric strategies to measure PFAS in blood and dust samples. There will be synergy between the three research aims by overlapping study participants (Aims 1 and 2), coordinating laboratory analyses (Aims 2 and 3) and statistical analyses (Aims 1, 2, 3), and by paying special attention to leukemia--the most common childhood cancer (Aims 1, 2, 3). The ViCTER Consortium will be supported by an Administrative and Scientific Oversight Core to coordinate and integrate resources and activities of the three research aims. With our unique resources, novel methods, and complementary expertise, this proposal responds to the urgent need of assessing population cancer risk to children related to PFAS.

项目摘要/摘要 多氟烷基物质（PFA）已用于许多制造和商业产品 近几十年来，尽管早期逐渐消失，但仍导致广泛和持续的污染 PFO和PFOA等化合物。 PFA暴露于人类的路线因年龄而异；而曝光 婴儿和儿童通常来自母乳喂养和摄入沉淀的灰尘，青少年和成人 主要通过食物和水暴露。 PFA与几种不良健康结果有关， 包括成人的癌症。尽管有几个报道称PFAS污染区域的儿童癌症集群，但 与成年人相比，儿童的身体负担可能更高，没有研究的研究 儿童的癌症风险部分是由于儿童癌的相对稀有性。我们建议进行第一个 通过整合四个机构的研究人员的专业知识，研究儿童的PFA和癌症 一个跨学科虚拟财团，在儿科和癌症流行病学方面具有专业知识以及环境 工程和健康科学。使用创新的方法论，该虚拟财团将表征PFA 通过检查饮用水中的PFA（AIM 1），新生儿和怀孕，从最相关的暴露途径中 血液样本（AIM 2）和家用灰尘（AIM 3）在怀孕到脆弱的暴露窗户期间 幼儿期以及随后患儿童癌的风险。我们将专注于曾经的癌症 以前在已知对PFA的社区和群体中报道了PFA，例如白血病， 横纹肌肉瘤，淋巴瘤和大脑，中枢神经系统，肾脏，睾丸和甲状腺的癌症。 我们将利用两项现有的加利福尼亚儿童癌症研究，并提供大型设计 儿童期癌症病例和使用居住信息的对照，并获得血液和灰尘 子集的样本。 PFAS水暴露评估，我们将使用贝叶斯药代动力学校准 结合了测得的饮用水浓度与测量的血清生物标志物的方法 改进的暴露估计。我们还将结合目标和非目标的质谱策略 测量血液和灰尘样品中的PFA。这三个研究目标之间将有协同作用 重叠的研究参与者（目标1和2），协调实验室分析（目标2和3）和统计 分析（目标1、2、3），并特别注意白血病 - 最常见的儿童癌症（Aims 1、2、3）。 Victer联盟将得到行政和科学监督核心的支持 协调和整合三项研究目的的资源和活动。凭借我们独特的资源，新颖 方法和互补的专业知识，该提案应对评估人口的迫切需求 与PFA有关的儿童的癌症风险。

项目成果

Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots - Demonstration of reproducibility and comparability to venous blood samples.

干血斑中全氟烷基物质和多氟烷基物质 (PFAS) 的痕量分析 - 证明静脉血样本的再现性和可比性。

• DOI: 10.1016/j.scitotenv.2023.163530
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Lin,ElizabethZ;Nason,SaraL;Zhong,Alexander;Fortner,John;GodriPollitt,KrystalJ
• 通讯作者: GodriPollitt,KrystalJ

Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.

• DOI: 10.1038/s41370-023-00603-4
• 发表时间: 2023-09
• 期刊: Journal of exposure science & environmental epidemiology
• 影响因子: 4.5
• 作者: Rosen Vollmar AK;Lin EZ;Nason SL;Santiago K;Johnson CH;Ma X;Godri Pollitt KJ;Deziel NC
• 通讯作者: Deziel NC

Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots.

通过对干血斑进行自动非靶向分析，在全血中发现了新型全氟烷基物质 (PFAS)。

• DOI: 10.1016/j.scitotenv.2023.163579
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Koelmel,JeremyP;Lin,ElizabethZ;Parry,Emily;Stelben,Paul;Rennie,EmmaE;GodriPollitt,KrystalJ
• 通讯作者: GodriPollitt,KrystalJ