Mechanisms of Risk and Resilience in Adolescent Drug Treatment and Recovery

青少年戒毒治疗和康复的风险和复原力机制

• 批准号: 9232312
• 负责人: Katherine Little Kivisto
• 金额: $ 31.28万
• 依托单位: UNIVERSITY OF INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9232312
• 关键词: Academic Research Enhancement Awards; Accidents; Accounting; Address; Adolescent; Adolescent Development; Adult; Alcohol or Other Drugs use; Area; Behavior; Behavior Therapy; Behavioral Paradigm; Brain; Cessation of life; Communities; Custom; Data; Data Analyses; Dependence; Development; Disease; Disease remission; Distress; Dropout; Emotions; Enrollment; Environment; Family; Future; Goals; Health Care Costs; Health Services; Individual; Injury; Intervention; Knowledge; Learning; Life; Literature; Maintenance; Manuscripts; Measurement; Measures; Methods; National Institute of Drug Abuse; Outpatients; Parents; Participant; Pathway interactions; Patient Self-Report; Pharmacotherapy; Physiological; Preparation; Prevention; Protocols documentation; Provider; Public Health; Recording of previous events; Recovery; Relapse; Reporting; Research; Research Personnel; Risk; Risk Factors; Self-control as a personality trait; Social support; Strategic Planning; Stress; Students; Substance Use Disorder; System; Time; To specify; Translating; Translational Research; Treatment outcome; Universities; addiction; adolescent substance use; base; biobehavior; career; computerized; coping mechanism; craving; early onset substance use; emotional distress; evidence base; experience; follow-up; implementation research; improved; life time cost; parental monitoring; peer; personalized intervention; resilience; retention rate; substance abuse treatment; symposium; trauma symptom; treatment program; undergraduate student

PROJECT SUMMARY/ABSTRACT Adolescent substance use disorders (SUDs) present a significant public health concern. Adolescents have high rates of relapse following SUD treatment, higher even than adults. Although much is known about risk and resilience pathways for the development of adolescent SUDs, much less is known about predictors and mechanisms of successful versus unsuccessful SUD treatment in adolescents. One mechanism that has shown promise in predicting poor treatment outcomes for adults is high distress intolerance (DI): the inability or perceived inability to withstand distressing emotions. The proposed research focuses on baseline levels of DI, as well as change in DI during and following an existing residential and intensive outpatient treatment program for adolescents. Approximately 134 adolescents will complete a comprehensive assessment of DI, including self-reports, physiological measurements, and DI tasks at baseline, 3 times during treatment, and 3 times during the 6-month follow-up period. Adolescents and parents will also complete assessments of known risk factors for the development and maintenance of SUDs, including adolescent and family substance use history, peer substance use, parental monitoring, social support, trauma symptoms, and internalizing/externalizing problems. During treatment and follow-up, adolescents will report their level of substance craving and substance use relapses. Based on participants' baseline DI and DI change over time, in combination with other measured risk factors, results of the proposed research will be used to predict levels of craving and future relapse. Specifically, results will provide within- and between-subjects profiles of adolescents at risk for a DI-based relapse. Further, because of the multiple assessments within subjects, the results of the proposed research can inform future interventions by demonstrating when a DI-based intervention might be the most needed or beneficial. Finally, in accordance with the key objectives of the AREA R15 program, students will gain invaluable experience in rigorous and intensive research in the areas of addictions, change mechanisms, and recovery. Students will participate in the implementation of research protocols, data analysis, manuscript preparation, and research presentations at conferences, strengthening the students' future career prospects, as well as enhancing the university's research environment.

项目概要/摘要 青少年物质使用障碍（SUD）是一个重大的公共卫生问题。 青少年接受 SUD 治疗后复发率很高，甚至高于成人。 尽管人们对青少年发展的风险和复原力途径了解很多 SUD，对成功与不成功的预测因素和机制知之甚少 青少年的 SUD 治疗。一种在预测贫困方面显示出希望的机制 成人的治疗结果是高度痛苦不耐受（DI）：无能力或感知到无能力 承受痛苦的情绪。拟议的研究重点是 DI 的基线水平，因为 以及现有住院和重症门诊患者期间和之后 DI 的变化 青少年治疗计划。大约 134 名青少年将完成 DI的综合评估，包括自我报告、生理测量和DI 基线任务、治疗期间 3 次、6 个月随访期间 3 次。 青少年和家长还将完成对已知风险因素的评估 制定和维护 SUD，包括青少年和家庭药物使用史， 同伴物质使用、父母监控、社会支持、创伤症状，以及 内化/外化问题。在治疗和随访期间，青少年将报告他们的情况 物质渴望和物质使用复发的程度。基于参与者的基线 DI 和 DI 随着时间的推移而变化，结合其他测量的风险因素，建议的结果 研究将用于预测渴望水平和未来的复发。具体来说，结果将 提供有 DI 复发风险的青少年的受试者内和受试者间概况。 此外，由于受试者内部进行了多次评估，拟议的结果 研究可以通过证明基于 DI 的干预措施何时可能为未来的干预措施提供信息 成为最需要或最有益的。最后，根据 AREA 的主要目标 R15项目，学生将在严格和深入的研究中获得宝贵的经验 成瘾、改变机制和康复领域。学生将参加 研究方案、数据分析、稿件准备和研究的实施 在会议上发表演讲，加强学生未来的职业前景，以及 改善大学的研究环境。