2022 Synaptic Transmission GRC/GRS

2022 突触传递 GRC/GRS

• 批准号: 9993707
• 负责人: ALISON L BARTH
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9993707
• 关键词: 3-Dimensional; Address; Adhesions; Alzheimer' s Disease; Anatomy; Area; Astrocytes; BRAIN initiative; Basic Science; Brain; Brain Diseases; Callithrix; Career Mobility; Clinical; Collaborations; Communication; Communities; Complex; Cryoelectron Microscopy; Data; Development; Disease; Drug Addiction; Electrophysiology (science); Elements; Environment; Ethnic Origin; Faculty; Functional disorder; Gender; Geographic Locations; Goals; Health; Hour; Human; Image; Individual; Institutes; Institution; International; Italy; Learning; Life; Link; Location; Memory; Mental Retardation; Mental disorders; Mentors; Modeling; Molecular; Molecular Biology; Mood Disorders; Nervous system structure; Neurodegenerative Disorders; Neurons; Neurosciences; Neurotransmitters; Organism; Organoids; Parkinson Disease; Participant; Pathology; Pattern; Physiology; Pluripotent Stem Cells; Postdoctoral Fellow; Preparation; Primates; Process; Property; Race; Regulation; Renaissance; Request for Proposals; Research; Research Personnel; Resolution; Schizophrenia; Science; Scientist; Series; Shapes; Short-Term Memory; Signal Transduction; Site; Social Interaction; Speed; Structure; Synapses; Synaptic Transmission; Synaptic plasticity; System; Technology; Time; Transgenic Organisms; Underrepresented Minority; United States National Institutes of Health; Woman; Work; autism spectrum disorder; career; design; frontier; graduate student; in vivo; innovation; interest; meetings; member; nervous system disorder; neural circuit; neuroregulation; novel strategies; optogenetics; posters; postsynaptic; presynaptic; programs; signal processing; symposium; synaptic function

Project Summary Synapses are key elements of communication and signal processing in the healthy brain. Furthermore, synapses are severely perturbed in several neurological and psychiatric diseases. This proposal requests support for an international scientific meeting on Synaptic Transmission as part of the Gordon Research Conference (GRC) series to be held at the Renaissance Tuscany Il Ciocco in Barga, Italy. This GRC will be preceded by a Gordon Research Seminar (GRS) targeted towards graduate students and post-doctoral fellows on June 20-21 at the same location. We will bring together scientists who all are highly interested in synaptic function but examine synapses at different levels (molecular, cellular, and systems level), look at them from different perspectives (bottom-up, top-down), and use different approaches (molecular biology, super-resolution imaging, 3D and cryo-electron microscopy, optogenetics, subcellular electrophysiology, modeling, and many others). The long-term objectives of the conference series are (1) to increase understanding of the fundamental molecular and cellular mechanisms of synaptic transmission, (2) to elucidate how synaptic transmission shapes neuronal network activity, and (3) to link basic science on synapses to understanding disease processes. We propose to build on the highly successful strategy of this traditional conference as well as implement innovative strategies for identifying and supporting under- represented minorities, and engaging trainees and established scientists using a mentor-mentee program. Thirty committed speakers will represent critical areas of synaptic transmission research for ~150 participants for an intense five-day conference in a retreat-like setting in Barga, Italy. The program will begin with a plenary session from a leader in the field, Guo-Ping Feng, who will talk about using transgenic marmosets to study synaptic dysfunction related to autism. Eight sessions will then address synaptic transmission from both pre- and postsynaptic perspectives including: structure, plasticity, signaling, artificial synaptic networks, pathology, relationships to perisynaptic astroglia, and the function of synapses in complex systems. Short talks and evening poster sessions on all four days will permit broad participation by trainees and junior faculty members. The final plenary talk will be given by Rob Malenka, a leader in studying synaptic plasticity who has focused on drug addiction. The health and disease relevance of this application is substantial. Although many presentations will focus on basic science, the data have far- reaching implications for devastating brain disorders that are emerging as synaptopathies including neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, mood disorders, schizophrenia, autism spectrum disorders, mental retardation, and drug addiction. The 2020 Synaptic Transmission GRC will have a major influence shaping both basic and disease-related neuroscience across the next decade.

项目概要 突触是健康大脑中沟通和信号处理的关键要素。 此外，突触在多种神经和精神疾病中受到严重干扰。这 提案请求支持关于突触传递的国际科学会议，作为该计划的一部分 戈登研究会议 (GRC) 系列将在意大利巴尔加的文艺复兴托斯卡纳 Il Ciocco 举行。 在 GRC 之前，将举办戈登研究研讨会 (GRS)，针对研究生和 博士后研究员于 6 月 20 日至 21 日在同一地点进行。我们将汇集高度顶尖的科学家 对突触功能感兴趣，但在不同级别（分子、细胞和系统）检查突触 级别），从不同的角度（自下而上、自上而下）看待它们，并使用不同的方法 （分子生物学、超分辨率成像、3D 和冷冻电子显微镜、光遗传学、亚细胞 电生理学、建模等）。该系列会议的长期目标是 (1) 增进对突触传递的基本分子和细胞机制的理解，(2) 阐明突触传递如何塑造神经元网络活动，以及（3）将基础科学联系起来 突触来了解疾病过程。我们建议以这一非常成功的战略为基础 传统会议以及实施创新战略来确定和支持欠缺 代表少数群体，并利用导师-受训者计划吸引受训者和知名科学家。 三十位忠诚的演讲者将代表约 150 场突触传递研究的关键领域 与会者在意大利巴尔加的一个静修般的环境中参加了为期五天的紧张会议。节目即将开始 该领域的领导者冯国平将在全体会议上讨论使用转基因技术 狨猴研究与自闭症相关的突触功能障碍。然后八次会议将讨论突触 从突触前和突触后两个角度进行传递，包括：结构、可塑性、信号传导、人工 突触网络、病理学、与突触周围星形胶质细胞的关系以及突触的功能 复杂的系统。四天的简短演讲和晚间海报会议将允许广泛参与 实习生和初级教员。最后的全体会议演讲将由 Rob Malenka 发表，他是 研究突触可塑性，专注于毒瘾。这与健康和疾病的相关性 应用量很大。尽管许多演讲将重点放在基础科学上，但数据已经远 对正在以突触病形式出现的破坏性脑部疾病产生影响，包括 神经退行性疾病，如帕金森病和阿尔茨海默病、情绪障碍、精神分裂症、 自闭症谱系障碍、精神障碍和毒瘾。 2020年突触传递GRC 将对未来十年基础神经科学和疾病相关神经科学的形成产生重大影响。